Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control
Introduction: Chromium is an essential micronutrient which is required for the normal functioning of insulin and regulation of blood sugar levels. It acts as a vital antioxidant for maintaining insulin homeostasis. In diabetes mellitus, the free radical production is increased and levels of anti...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-11-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6753/16062_CE(RA1)_F(T)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1818450728296906752 |
|---|---|
| author | Kannan Rajendran Senthil Manikandan Lal Devayanivasudevan Nair Rajendran Karuth Odiyil Nikhilan Vijayarajan Rajiv Gnanasekar Vivian V. Kapil Azeem S. Mohamed |
| author_facet | Kannan Rajendran Senthil Manikandan Lal Devayanivasudevan Nair Rajendran Karuth Odiyil Nikhilan Vijayarajan Rajiv Gnanasekar Vivian V. Kapil Azeem S. Mohamed |
| author_sort | Kannan Rajendran |
| collection | DOAJ |
| description | Introduction: Chromium is an essential micronutrient which is
required for the normal functioning of insulin and regulation of
blood sugar levels. It acts as a vital antioxidant for maintaining
insulin homeostasis. In diabetes mellitus, the free radical
production is increased and levels of antioxidants like chromium,
vanadium, selenium and manganese are reduced. There have
been previous studies to suggest that low serum levels of
chromium are associated with poorer glycaemic control.
Aim: To study the level of serum chromium in newly diagnosed
patients with type 2 diabetes mellitus and its association with
glycaemic control.
Materials and Methods: Serum chromium concentration
was determined by using inductively coupled Plasma –
Optical Emission Spectophotometry in 42 newly diagnosed
type 2 diabetes mellitus patients without any pre-existing
complications. They were divided into 2 groups – well controlled
(HbA1c ≤7.0%) and uncontrolled groups (HbA1c >7.0%).
Results: Mean serum chromium concentration measured in
uncontrolled type 2 diabetic patients was significantly lower
(0.065 ± 0.03 mcg/L vs 0.103 ± 0.04 mcg/L, p< 0.05). There was
a statistically significant inverse linear correlation of the HbA1c
values and the serum chromium concentration (r= -0.6514, p <
0.0001). There was also a decrease in chromium levels across
both the groups with advancing age and the decrease being
significant beyond 40 years of age (p<0.05).
Conclusion: The results of our study describes the relationship
between serum chromium levels and control of type 2 diabetes
mellitus. Significant reduction in chromium levels are probable
indicators of metabolic response to oxidative stress in patients
with type 2 diabetes mellitus. Further large scale studies relating
serum chromium and type 2 diabetes mellitus may help to
understand more about the exact relationship. |
| first_indexed | 2024-12-14T20:55:55Z |
| format | Article |
| id | doaj.art-03acfb7e35874147a43c8404aa939529 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T20:55:55Z |
| publishDate | 2015-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-03acfb7e35874147a43c8404aa9395292022-12-21T22:47:41ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-11-01911OC05OC0810.7860/JCDR/2015/16062.6753Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic ControlKannan Rajendran0Senthil Manikandan1Lal Devayanivasudevan Nair2Rajendran Karuth Odiyil3Nikhilan Vijayarajan4Rajiv Gnanasekar5Vivian V. Kapil6Azeem S. Mohamed7Associate Professor Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University, Thandalam, Chennai, Tamilnadu, India.Assistant Professor, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University, Thandalam, Chennai, Tamilnadu, India. Assistant Professor, Department of Pediatrics, Saveetha Medical College & Hospital, Saveetha University, Thandalam, Chennai, Tamilnadu, India.Professor, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University, Thandalam, Chennai, Tamilnadu, India.Interns, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University, Thandalam, Chennai, Tamilnadu, India.Interns, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University, Thandalam, Chennai, Tamilnadu, India.Interns, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University, Thandalam, Chennai, Tamilnadu, India.Interns, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University, Thandalam, Chennai, Tamilnadu, India.Introduction: Chromium is an essential micronutrient which is required for the normal functioning of insulin and regulation of blood sugar levels. It acts as a vital antioxidant for maintaining insulin homeostasis. In diabetes mellitus, the free radical production is increased and levels of antioxidants like chromium, vanadium, selenium and manganese are reduced. There have been previous studies to suggest that low serum levels of chromium are associated with poorer glycaemic control. Aim: To study the level of serum chromium in newly diagnosed patients with type 2 diabetes mellitus and its association with glycaemic control. Materials and Methods: Serum chromium concentration was determined by using inductively coupled Plasma – Optical Emission Spectophotometry in 42 newly diagnosed type 2 diabetes mellitus patients without any pre-existing complications. They were divided into 2 groups – well controlled (HbA1c ≤7.0%) and uncontrolled groups (HbA1c >7.0%). Results: Mean serum chromium concentration measured in uncontrolled type 2 diabetic patients was significantly lower (0.065 ± 0.03 mcg/L vs 0.103 ± 0.04 mcg/L, p< 0.05). There was a statistically significant inverse linear correlation of the HbA1c values and the serum chromium concentration (r= -0.6514, p < 0.0001). There was also a decrease in chromium levels across both the groups with advancing age and the decrease being significant beyond 40 years of age (p<0.05). Conclusion: The results of our study describes the relationship between serum chromium levels and control of type 2 diabetes mellitus. Significant reduction in chromium levels are probable indicators of metabolic response to oxidative stress in patients with type 2 diabetes mellitus. Further large scale studies relating serum chromium and type 2 diabetes mellitus may help to understand more about the exact relationship.https://jcdr.net/articles/PDF/6753/16062_CE(RA1)_F(T)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdfhyperglycemiamicrovascular complicationsretinopathy |
| spellingShingle | Kannan Rajendran Senthil Manikandan Lal Devayanivasudevan Nair Rajendran Karuth Odiyil Nikhilan Vijayarajan Rajiv Gnanasekar Vivian V. Kapil Azeem S. Mohamed Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control Journal of Clinical and Diagnostic Research hyperglycemia microvascular complications retinopathy |
| title | Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control |
| title_full | Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control |
| title_fullStr | Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control |
| title_full_unstemmed | Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control |
| title_short | Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control |
| title_sort | serum chromium levels in type 2 diabetic patients and its association with glycaemic control |
| topic | hyperglycemia microvascular complications retinopathy |
| url | https://jcdr.net/articles/PDF/6753/16062_CE(RA1)_F(T)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdf |
| work_keys_str_mv | AT kannanrajendran serumchromiumlevelsintype2diabeticpatientsanditsassociationwithglycaemiccontrol AT senthilmanikandan serumchromiumlevelsintype2diabeticpatientsanditsassociationwithglycaemiccontrol AT laldevayanivasudevannair serumchromiumlevelsintype2diabeticpatientsanditsassociationwithglycaemiccontrol AT rajendrankaruthodiyil serumchromiumlevelsintype2diabeticpatientsanditsassociationwithglycaemiccontrol AT nikhilanvijayarajan serumchromiumlevelsintype2diabeticpatientsanditsassociationwithglycaemiccontrol AT rajivgnanasekar serumchromiumlevelsintype2diabeticpatientsanditsassociationwithglycaemiccontrol AT vivianvkapil serumchromiumlevelsintype2diabeticpatientsanditsassociationwithglycaemiccontrol AT azeemsmohamed serumchromiumlevelsintype2diabeticpatientsanditsassociationwithglycaemiccontrol |