Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes

Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes

Abstract Background In pre-clinical research, systematic reviews have the potential to mitigate translational challenges by facilitating understanding of how pre-clinical studies can inform future clinical research. Yet their conduct is encumbered by heterogeneity in the outcomes measured and report...

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Bibliographic Details
Main Authors: Nicola L. Harman, Adrián Sanz-Moreno, Stamatia Papoutsopoulou, Katie A. Lloyd, Kamar E. Ameen-Ali, Malcolm Macleod, Paula R. Williamson
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Journal of Translational Medicine
Subjects:
Type 2 diabetes
Pre-clinical research
Mouse models of type 2 diabetes
Core outcome set
Translational research
Clinical research
Online Access:https://doi.org/10.1186/s12967-020-02649-6

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