Insights into In Vitro Adaptation of EV71 and Analysis of Reduced Virulence by In Silico Predictions

Insights into In Vitro Adaptation of EV71 and Analysis of Reduced Virulence by In Silico Predictions

EV-A71 is a common viral pathogen that causes hand, foot and mouth disease. It is a single-stranded RNA virus that has a low fidelity RNA polymerase and, as a result, spontaneous mutations frequently occur in the EV-A71 genome. The mutations within the genome give rise to quasispecies within the vir...

Full description

Bibliographic Details
Main Authors: Jia Xuen Koh, Malihe Masomian, Mohd Ishtiaq Anasir, Seng-Kai Ong, Chit Laa Poh
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Vaccines
Subjects:
enterovirus 71
quasispecies
spontaneous mutations
in vitro virulence
structural analysis
next-generation sequencing
Online Access:https://www.mdpi.com/2076-393X/11/3/629

Similar Items

Similar Items