Infection pre-Ad26.COV2.S-vaccination primes greater class switching and reduced CXCR5 expression by SARS-CoV-2-specific memory B cells

Infection pre-Ad26.COV2.S-vaccination primes greater class switching and reduced CXCR5 expression by SARS-CoV-2-specific memory B cells

Abstract Neutralizing antibodies strongly correlate with protection for COVID-19 vaccines, but the corresponding memory B cells that form to protect against future infection are relatively understudied. Here we examine the effect of prior SARS-CoV-2 infection on the magnitude and phenotype of the me...

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Hlavní autoři: Robert G. E. Krause, Thandeka Moyo-Gwete, Simone I. Richardson, Zanele Makhado, Nelia P. Manamela, Tandile Hermanus, Nonhlanhla N. Mkhize, Roanne Keeton, Ntombi Benede, Mathilda Mennen, Sango Skelem, Farina Karim, Khadija Khan, Catherine Riou, Ntobeko A. B. Ntusi, Ameena Goga, Glenda Gray, Willem Hanekom, Nigel Garrett, Linda-Gail Bekker, Andreas Groll, Alex Sigal, Penny L. Moore, Wendy A. Burgers, Alasdair Leslie
Médium: Článek
Jazyk:English
Vydáno: Nature Portfolio 2023-08-01
Edice:npj Vaccines
On-line přístup:https://doi.org/10.1038/s41541-023-00724-9

Internet

https://doi.org/10.1038/s41541-023-00724-9

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