Role of Omeprazole as An Antifungal Agent
The antifungal activity of various concentrations of omeprazole (0.1mg/ml, 0.25mg/ml, 0.5mg/ml, 1mg/ml, 2.5mg/ml, 5mg/ml, 10mg/ml, and 20mg/ml) were studied in different pH media (5 and 7) against Aspergillus niger, and Trichophyton urbrum.The laboratory results showed the inhibitory effect of omepr...
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| Format: | Article |
| Language: | English |
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Unviversity of Technology- Iraq
2011-01-01
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| Series: | Engineering and Technology Journal |
| Online Access: | https://etj.uotechnology.edu.iq/article_26170_8b9825d1f615f7f6254c97ec73f86acf.pdf |
| _version_ | 1797325483189207040 |
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| author | Omar A. Al-Mukhtar Suhad A. Ahmad Raya R. Jabri Ali A. Juwaied |
| author_facet | Omar A. Al-Mukhtar Suhad A. Ahmad Raya R. Jabri Ali A. Juwaied |
| author_sort | Omar A. Al-Mukhtar |
| collection | DOAJ |
| description | The antifungal activity of various concentrations of omeprazole (0.1mg/ml, 0.25mg/ml, 0.5mg/ml, 1mg/ml, 2.5mg/ml, 5mg/ml, 10mg/ml, and 20mg/ml) were studied in different pH media (5 and 7) against Aspergillus niger, and Trichophyton urbrum.The laboratory results showed the inhibitory effect of omeprazole against Aspergillus niger at pH 7 and starting from concentration 10mg/ml, and against Trichophyton urbrum starting from 1mg/ml. While its antifungal activity in a medium with pH 5 was extended to reach the lower concentrations 0.25mg/ml against selected fungi. Accordingly, omeprazole is pH dependent.It seems that omeprazole changed cell membrane potential of selected fungal species which led to depolarization of cell membrane as a result of inhibition of the proton pump mechanism. This made the fungal cell not willing to uptake chemicals needed for living.Keywords: omeprazole, proton pump inhibitor, antifungal agent, Aspergillus niger, and Trichophyton urbrum. |
| first_indexed | 2024-03-08T06:10:05Z |
| format | Article |
| id | doaj.art-03b3a4dcc9e04fd499941a5d9b13be6a |
| institution | Directory Open Access Journal |
| issn | 1681-6900 2412-0758 |
| language | English |
| last_indexed | 2024-03-08T06:10:05Z |
| publishDate | 2011-01-01 |
| publisher | Unviversity of Technology- Iraq |
| record_format | Article |
| series | Engineering and Technology Journal |
| spelling | doaj.art-03b3a4dcc9e04fd499941a5d9b13be6a2024-02-04T17:41:13ZengUnviversity of Technology- IraqEngineering and Technology Journal1681-69002412-07582011-01-0129233634010.30684/etj.29.2.1326170Role of Omeprazole as An Antifungal AgentOmar A. Al-MukhtarSuhad A. AhmadRaya R. JabriAli A. JuwaiedThe antifungal activity of various concentrations of omeprazole (0.1mg/ml, 0.25mg/ml, 0.5mg/ml, 1mg/ml, 2.5mg/ml, 5mg/ml, 10mg/ml, and 20mg/ml) were studied in different pH media (5 and 7) against Aspergillus niger, and Trichophyton urbrum.The laboratory results showed the inhibitory effect of omeprazole against Aspergillus niger at pH 7 and starting from concentration 10mg/ml, and against Trichophyton urbrum starting from 1mg/ml. While its antifungal activity in a medium with pH 5 was extended to reach the lower concentrations 0.25mg/ml against selected fungi. Accordingly, omeprazole is pH dependent.It seems that omeprazole changed cell membrane potential of selected fungal species which led to depolarization of cell membrane as a result of inhibition of the proton pump mechanism. This made the fungal cell not willing to uptake chemicals needed for living.Keywords: omeprazole, proton pump inhibitor, antifungal agent, Aspergillus niger, and Trichophyton urbrum.https://etj.uotechnology.edu.iq/article_26170_8b9825d1f615f7f6254c97ec73f86acf.pdf |
| spellingShingle | Omar A. Al-Mukhtar Suhad A. Ahmad Raya R. Jabri Ali A. Juwaied Role of Omeprazole as An Antifungal Agent Engineering and Technology Journal |
| title | Role of Omeprazole as An Antifungal Agent |
| title_full | Role of Omeprazole as An Antifungal Agent |
| title_fullStr | Role of Omeprazole as An Antifungal Agent |
| title_full_unstemmed | Role of Omeprazole as An Antifungal Agent |
| title_short | Role of Omeprazole as An Antifungal Agent |
| title_sort | role of omeprazole as an antifungal agent |
| url | https://etj.uotechnology.edu.iq/article_26170_8b9825d1f615f7f6254c97ec73f86acf.pdf |
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