Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease
AbstractBackground End-stage renal disease (ESRD) patients have functional and structural brain abnormalities. The cerebellum also showed varying degrees of damage. However, no studies on cerebellar-cerebral functional connectivity (FC) have been conducted in ESRD patients. This study aimed to inves...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2238829 |
| _version_ | 1797658481682022400 |
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| author | Jie Fang Yingying Miao Fan Zou Yarui Liu Jiangle Zuo Xiangming Qi Haibao Wang |
| author_facet | Jie Fang Yingying Miao Fan Zou Yarui Liu Jiangle Zuo Xiangming Qi Haibao Wang |
| author_sort | Jie Fang |
| collection | DOAJ |
| description | AbstractBackground End-stage renal disease (ESRD) patients have functional and structural brain abnormalities. The cerebellum also showed varying degrees of damage. However, no studies on cerebellar-cerebral functional connectivity (FC) have been conducted in ESRD patients. This study aimed to investigate the changes in cerebellar-cerebral FC in ESRD patients and its relationship with neuropsychological and clinical indexes.Methods Resting-state functional magnetic resonance imaging and neuropsychological assessment were performed on 37 ESRD patients and 35 control subjects. Seed-based FC analysis was performed to investigate inter-group differences in cerebellar-cerebral FC. In addition, the relations of altered FC with the neuropsychological function and clinical indicators were analyzed in ERSD patients.Results ESRD patients exhibited alterations in cerebellar-cerebral FC involving the executive control network, default mode network, and affective-limbic network compared to control subjects (False discovery rate-corrected, p < 0.05). The altered cerebellar-cerebral FC was associated with the Montreal Cognitive Assessment Scale score (p < 0.05), and correlated with serum creatinine and uric acid levels within the ESRD group (p < 0.05).Conclusions The study indicates that cerebellar-cerebral FC is involved in the neural substrates of cognitive impairment in ESRD patients. The findings may provide clinically relevant new neuroimaging biomarkers for the neuropathological mechanisms underlying cognitive impairment of ESRD. |
| first_indexed | 2024-03-11T17:59:34Z |
| format | Article |
| id | doaj.art-03b491200d2e432b897ca0c097b3288f |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-03-11T17:59:34Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-03b491200d2e432b897ca0c097b3288f2023-10-17T09:23:23ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2238829Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal diseaseJie Fang0Yingying Miao1Fan Zou2Yarui Liu3Jiangle Zuo4Xiangming Qi5Haibao Wang6Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, P.R. ChinaDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, P.R. ChinaDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, P.R. ChinaDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, P.R. ChinaDepartment of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, P.R. ChinaDepartment of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, P.R. ChinaDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, P.R. ChinaAbstractBackground End-stage renal disease (ESRD) patients have functional and structural brain abnormalities. The cerebellum also showed varying degrees of damage. However, no studies on cerebellar-cerebral functional connectivity (FC) have been conducted in ESRD patients. This study aimed to investigate the changes in cerebellar-cerebral FC in ESRD patients and its relationship with neuropsychological and clinical indexes.Methods Resting-state functional magnetic resonance imaging and neuropsychological assessment were performed on 37 ESRD patients and 35 control subjects. Seed-based FC analysis was performed to investigate inter-group differences in cerebellar-cerebral FC. In addition, the relations of altered FC with the neuropsychological function and clinical indicators were analyzed in ERSD patients.Results ESRD patients exhibited alterations in cerebellar-cerebral FC involving the executive control network, default mode network, and affective-limbic network compared to control subjects (False discovery rate-corrected, p < 0.05). The altered cerebellar-cerebral FC was associated with the Montreal Cognitive Assessment Scale score (p < 0.05), and correlated with serum creatinine and uric acid levels within the ESRD group (p < 0.05).Conclusions The study indicates that cerebellar-cerebral FC is involved in the neural substrates of cognitive impairment in ESRD patients. The findings may provide clinically relevant new neuroimaging biomarkers for the neuropathological mechanisms underlying cognitive impairment of ESRD.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2238829End-stage renal diseasecerebellumresting-state fMRIfunctional connectivitycognitive impairment |
| spellingShingle | Jie Fang Yingying Miao Fan Zou Yarui Liu Jiangle Zuo Xiangming Qi Haibao Wang Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease Renal Failure End-stage renal disease cerebellum resting-state fMRI functional connectivity cognitive impairment |
| title | Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease |
| title_full | Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease |
| title_fullStr | Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease |
| title_full_unstemmed | Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease |
| title_short | Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease |
| title_sort | altered resting state cerebellar cerebral functional connectivity in patients with end stage renal disease |
| topic | End-stage renal disease cerebellum resting-state fMRI functional connectivity cognitive impairment |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2238829 |
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