Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment
Lung cancer is the leading cause of death from cancer worldwide. Recent studies demonstrated that the tumour microenvironment (TME) is pivotal for tumour progression, providing multiple targeting opportunities for therapeutic strategies. As one of the most abundant stromal cell types in the TME, tum...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2020-10-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/29/157/200134.full |
| _version_ | 1818523113254551552 |
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| author | Xiang Zheng Siavash Mansouri Annika Krager Friedrich Grimminger Werner Seeger Soni S. Pullamsetti Craig E. Wheelock Rajkumar Savai |
| author_facet | Xiang Zheng Siavash Mansouri Annika Krager Friedrich Grimminger Werner Seeger Soni S. Pullamsetti Craig E. Wheelock Rajkumar Savai |
| author_sort | Xiang Zheng |
| collection | DOAJ |
| description | Lung cancer is the leading cause of death from cancer worldwide. Recent studies demonstrated that the tumour microenvironment (TME) is pivotal for tumour progression, providing multiple targeting opportunities for therapeutic strategies. As one of the most abundant stromal cell types in the TME, tumour-associated macrophages (TAMs) exhibit high plasticity. Malignant cells alter their metabolic profiles to adapt to the limited availability of oxygen and nutrients in the TME, resulting in functional alteration of TAMs. The metabolic features of TAMs are strongly associated with their functional plasticity, which further impacts metabolic profiling in the TME and contributes to tumourigenesis and progression. Here, we review the functional determination of the TME by TAM metabolic alterations, including glycolysis as well as fatty acid and amino acid metabolism, which in turn are influenced by environmental changes. Additionally, we discuss metabolic reprogramming of TAMs to a tumouricidal phenotype as a potential antitumoural therapeutic strategy. |
| first_indexed | 2024-12-11T05:41:12Z |
| format | Article |
| id | doaj.art-03b5a88b24494b4999b2aad5db14a5e3 |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-12-11T05:41:12Z |
| publishDate | 2020-10-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-03b5a88b24494b4999b2aad5db14a5e32022-12-22T01:19:07ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172020-10-012915710.1183/16000617.0134-20200134-2020Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironmentXiang Zheng0Siavash Mansouri1Annika Krager2Friedrich Grimminger3Werner Seeger4Soni S. Pullamsetti5Craig E. Wheelock6Rajkumar Savai7 Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany Dept of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, Giessen, Germany Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany Division of Physiological Chemistry 2, Dept of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany Lung cancer is the leading cause of death from cancer worldwide. Recent studies demonstrated that the tumour microenvironment (TME) is pivotal for tumour progression, providing multiple targeting opportunities for therapeutic strategies. As one of the most abundant stromal cell types in the TME, tumour-associated macrophages (TAMs) exhibit high plasticity. Malignant cells alter their metabolic profiles to adapt to the limited availability of oxygen and nutrients in the TME, resulting in functional alteration of TAMs. The metabolic features of TAMs are strongly associated with their functional plasticity, which further impacts metabolic profiling in the TME and contributes to tumourigenesis and progression. Here, we review the functional determination of the TME by TAM metabolic alterations, including glycolysis as well as fatty acid and amino acid metabolism, which in turn are influenced by environmental changes. Additionally, we discuss metabolic reprogramming of TAMs to a tumouricidal phenotype as a potential antitumoural therapeutic strategy.http://err.ersjournals.com/content/29/157/200134.full |
| spellingShingle | Xiang Zheng Siavash Mansouri Annika Krager Friedrich Grimminger Werner Seeger Soni S. Pullamsetti Craig E. Wheelock Rajkumar Savai Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment European Respiratory Review |
| title | Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment |
| title_full | Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment |
| title_fullStr | Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment |
| title_full_unstemmed | Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment |
| title_short | Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment |
| title_sort | metabolism in tumour associated macrophages a quid pro quo with the tumour microenvironment |
| url | http://err.ersjournals.com/content/29/157/200134.full |
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