The Structure of an AAV5-AAVR Complex at 2.5 Å Resolution: Implications for Cellular Entry and Immune Neutralization of AAV Gene Therapy Vectors
Adeno-Associated Virus is the leading vector for gene therapy. Although it is the vector for all in vivo gene therapies approved for clinical use by the US Food and Drug Administration, its biology is still not yet fully understood. It has been shown that different serotypes of AAV bind to their cel...
Main Authors: | Mark A. Silveria, Edward E. Large, Grant M. Zane, Tommi A. White, Michael S. Chapman |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-11-01
|
Series: | Viruses |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4915/12/11/1326 |
Similar Items
-
Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry
by: Edward E. Large, et al.
Published: (2021-07-01) -
Thorough molecular configuration analysis of noncanonical AAV genomes in AAV vector preparations
by: Junping Zhang, et al.
Published: (2024-03-01) -
Preclinical Assessment of Immune Responses to AAV (adeno-associated virus) Vectors
by: Etiena eBasner-Tschakarjan, et al.
Published: (2014-02-01) -
Thermal Stability as a Determinant of AAV Serotype Identity
by: Antonette Bennett, et al.
Published: (2017-09-01) -
AAV genome modification for efficient AAV production
by: Walaa Asaad, et al.
Published: (2023-04-01)