The ADRB3 rs4994 polymorphism increases risk of childhood and adolescent overweight/obesity for East Asia’s population: an evidence-based meta-analysis
Whether the Adrenoceptor Beta 3 (ADRB3) gene rs4994 polymorphism could affect the individual risk of childhood and adolescent overweight/obesity remains controversial. This meta-analysis was performed to estimate the prevalence of this polymorphism in overweight/obesity, and test the potential assoc...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Adipocyte |
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| Online Access: | http://dx.doi.org/10.1080/21623945.2020.1722549 |
| _version_ | 1818972759806443520 |
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| author | Chenyao Xie Wenxi Hua Yuening Zhao Jingwen Rui Jiarong Feng Yanjie Chen Yu Liu Jingjing Liu Xiaoqin Yang Xiaojing Xu |
| author_facet | Chenyao Xie Wenxi Hua Yuening Zhao Jingwen Rui Jiarong Feng Yanjie Chen Yu Liu Jingjing Liu Xiaoqin Yang Xiaojing Xu |
| author_sort | Chenyao Xie |
| collection | DOAJ |
| description | Whether the Adrenoceptor Beta 3 (ADRB3) gene rs4994 polymorphism could affect the individual risk of childhood and adolescent overweight/obesity remains controversial. This meta-analysis was performed to estimate the prevalence of this polymorphism in overweight/obesity, and test the potential association by summarizing existing evidence. Comprehensive literature search in PubMed, Web of Science, Cochrane Library, Wanfang, and CNKI databases was performed to identify eligible data sets. Finally, 16 studies involving 5,147 overweight/obese cases and 7,350 non-obese controls were included for further synthetic analyses. Odds ratio (OR) and its corresponding 95% confidence intervals (CIs) were statistically calculated. Totally, 69.9% of the included subjects came from East Asia. In the meta-analysis for overall population, statistically significant associations with increased risk of childhood and adolescent overweight/obesity were identified in allele model (OR 1.23, 95% CI 1.10–1.38), heterozygote model (OR 1.39, 95% CI 1.16–1.68), and dominant model (OR 1.31, 95% CI 1.12–1.54). Further stratified analysis according to geographical regions revealed that the statistical significance could only be detected in the East Asia subgroup in allele model, homozygote model, heterozygote model, and dominant model. In summary, our meta-analysis indicated that the ADRB3 rs4994 polymorphism could significantly increase the risk of childhood and adolescent overweight/obesity, especially for the East Asia’s population. |
| first_indexed | 2024-12-20T15:13:23Z |
| format | Article |
| id | doaj.art-03b60372bd254459ae0128f5d101743b |
| institution | Directory Open Access Journal |
| issn | 2162-3945 2162-397X |
| language | English |
| last_indexed | 2024-12-20T15:13:23Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Adipocyte |
| spelling | doaj.art-03b60372bd254459ae0128f5d101743b2022-12-21T19:36:14ZengTaylor & Francis GroupAdipocyte2162-39452162-397X2020-01-0191778610.1080/21623945.2020.17225491722549The ADRB3 rs4994 polymorphism increases risk of childhood and adolescent overweight/obesity for East Asia’s population: an evidence-based meta-analysisChenyao Xie0Wenxi Hua1Yuening Zhao2Jingwen Rui3Jiarong Feng4Yanjie Chen5Yu Liu6Jingjing Liu7Xiaoqin Yang8Xiaojing Xu9School of Biology and Basic Medical Science, Soochow UniversitySoochow UniversitySoochow UniversitySoochow UniversitySchool of Biology and Basic Medical Science, Soochow UniversitySchool of Biology and Basic Medical Science, Soochow UniversitySchool of Biology and Basic Medical Science, Soochow UniversitySoochow UniversitySchool of Biology and Basic Medical Science, Soochow UniversitySoochow UniversityWhether the Adrenoceptor Beta 3 (ADRB3) gene rs4994 polymorphism could affect the individual risk of childhood and adolescent overweight/obesity remains controversial. This meta-analysis was performed to estimate the prevalence of this polymorphism in overweight/obesity, and test the potential association by summarizing existing evidence. Comprehensive literature search in PubMed, Web of Science, Cochrane Library, Wanfang, and CNKI databases was performed to identify eligible data sets. Finally, 16 studies involving 5,147 overweight/obese cases and 7,350 non-obese controls were included for further synthetic analyses. Odds ratio (OR) and its corresponding 95% confidence intervals (CIs) were statistically calculated. Totally, 69.9% of the included subjects came from East Asia. In the meta-analysis for overall population, statistically significant associations with increased risk of childhood and adolescent overweight/obesity were identified in allele model (OR 1.23, 95% CI 1.10–1.38), heterozygote model (OR 1.39, 95% CI 1.16–1.68), and dominant model (OR 1.31, 95% CI 1.12–1.54). Further stratified analysis according to geographical regions revealed that the statistical significance could only be detected in the East Asia subgroup in allele model, homozygote model, heterozygote model, and dominant model. In summary, our meta-analysis indicated that the ADRB3 rs4994 polymorphism could significantly increase the risk of childhood and adolescent overweight/obesity, especially for the East Asia’s population.http://dx.doi.org/10.1080/21623945.2020.1722549adrb3genetic polymorphismobesitymeta-analysis |
| spellingShingle | Chenyao Xie Wenxi Hua Yuening Zhao Jingwen Rui Jiarong Feng Yanjie Chen Yu Liu Jingjing Liu Xiaoqin Yang Xiaojing Xu The ADRB3 rs4994 polymorphism increases risk of childhood and adolescent overweight/obesity for East Asia’s population: an evidence-based meta-analysis Adipocyte adrb3 genetic polymorphism obesity meta-analysis |
| title | The ADRB3 rs4994 polymorphism increases risk of childhood and adolescent overweight/obesity for East Asia’s population: an evidence-based meta-analysis |
| title_full | The ADRB3 rs4994 polymorphism increases risk of childhood and adolescent overweight/obesity for East Asia’s population: an evidence-based meta-analysis |
| title_fullStr | The ADRB3 rs4994 polymorphism increases risk of childhood and adolescent overweight/obesity for East Asia’s population: an evidence-based meta-analysis |
| title_full_unstemmed | The ADRB3 rs4994 polymorphism increases risk of childhood and adolescent overweight/obesity for East Asia’s population: an evidence-based meta-analysis |
| title_short | The ADRB3 rs4994 polymorphism increases risk of childhood and adolescent overweight/obesity for East Asia’s population: an evidence-based meta-analysis |
| title_sort | adrb3 rs4994 polymorphism increases risk of childhood and adolescent overweight obesity for east asia s population an evidence based meta analysis |
| topic | adrb3 genetic polymorphism obesity meta-analysis |
| url | http://dx.doi.org/10.1080/21623945.2020.1722549 |
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