Ethnic and Sociocultural Differences in Ovarian Reserve: Age-Specific Anti-Müllerian Hormone Values and Antral Follicle Count for Women of the Arabian Peninsula
BackgroundAnti-Müllerian hormone (AMH) and antral follicle count (AFC) age-specific reference values form the basis of infertility treatments, yet they were based upon studies performed primarily on Caucasian populations. However, they may vary across different age-matched ethnic populations. This s...
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.735116/full |
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| author | Laura Melado Raquel Vitorino Carol Coughlan Leyla Depret Bixio Ana Arnanz Ana Arnanz Ibrahim Elkhatib Neelke De Munck Human M. Fatemi Barbara Lawrenz Barbara Lawrenz |
| author_facet | Laura Melado Raquel Vitorino Carol Coughlan Leyla Depret Bixio Ana Arnanz Ana Arnanz Ibrahim Elkhatib Neelke De Munck Human M. Fatemi Barbara Lawrenz Barbara Lawrenz |
| author_sort | Laura Melado |
| collection | DOAJ |
| description | BackgroundAnti-Müllerian hormone (AMH) and antral follicle count (AFC) age-specific reference values form the basis of infertility treatments, yet they were based upon studies performed primarily on Caucasian populations. However, they may vary across different age-matched ethnic populations. This study aimed to describe age-specific serum AMH and AFC for women native to the Arabian Peninsula.MethodsA retrospective large-scale study was performed including 2,495 women, aged 19 to 50 years, native to the Arabian Peninsula. AMH and AFC were measured as part of their fertility assessment at tertiary-care fertility centres. Age-specific values and nomograms were calculated.Results2,495 women were evaluated. Mean, standard deviation and median values were calculated for AMH and AFC by 1-year and 5-years intervals. Median age was 34.81 years, median AMH was 1.76ng/ml and median AFC was 11. From the total group, 40.60% presented with AMH levels below 1.3ng/mL. For women <45 years old, the decrease in AFC was between -0.6/-0.8 per year. Up to 36 years old, the decrease of AMH was 0.1ng/ml. However, from 36 to 40 years old, an accelerated decline of 0.23ng/ml yearly was noted. In keeping with local customs, 71.23% of women wore the hijab and 25.76% the niqab. AMH and AFC were significantly lower for niqab group compared with hijab group (p=0.02 and p=0.04, respectively).ConclusionThis is to-date the largest data set on age-specific AMH and AFC values in women from the Arabian Peninsula aiming to increase clinical awareness of the ovarian reserve in this population. |
| first_indexed | 2024-12-14T09:03:11Z |
| format | Article |
| id | doaj.art-03b70e12dcdd48a4be4e1835b4617387 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-14T09:03:11Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-03b70e12dcdd48a4be4e1835b46173872022-12-21T23:08:46ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-10-011210.3389/fendo.2021.735116735116Ethnic and Sociocultural Differences in Ovarian Reserve: Age-Specific Anti-Müllerian Hormone Values and Antral Follicle Count for Women of the Arabian PeninsulaLaura Melado0Raquel Vitorino1Carol Coughlan2Leyla Depret Bixio3Ana Arnanz4Ana Arnanz5Ibrahim Elkhatib6Neelke De Munck7Human M. Fatemi8Barbara Lawrenz9Barbara Lawrenz10Medical Department, ART Fertility Clinics, Abu Dhabi, United Arab EmiratesMedical Department, ART Fertility Clinics, Abu Dhabi, United Arab EmiratesMedical Department, Advanced Reproductive Technologies (ART) Fertility Clinics, Dubai, United Arab EmiratesBiostatistics Department, Consofi Pharma, Dubai, United Arab EmiratesMedical Department, ART Fertility Clinics, Abu Dhabi, United Arab EmiratesDepartamento de Biomedicina y Biotecnología, Universidad de Alcalá, Madrid, SpainMedical Department, ART Fertility Clinics, Abu Dhabi, United Arab EmiratesMedical Department, ART Fertility Clinics, Abu Dhabi, United Arab EmiratesMedical Department, ART Fertility Clinics, Abu Dhabi, United Arab EmiratesMedical Department, ART Fertility Clinics, Abu Dhabi, United Arab EmiratesMedical Department, Women’s University Hospital Tuebingen, Tuebingen, GermanyBackgroundAnti-Müllerian hormone (AMH) and antral follicle count (AFC) age-specific reference values form the basis of infertility treatments, yet they were based upon studies performed primarily on Caucasian populations. However, they may vary across different age-matched ethnic populations. This study aimed to describe age-specific serum AMH and AFC for women native to the Arabian Peninsula.MethodsA retrospective large-scale study was performed including 2,495 women, aged 19 to 50 years, native to the Arabian Peninsula. AMH and AFC were measured as part of their fertility assessment at tertiary-care fertility centres. Age-specific values and nomograms were calculated.Results2,495 women were evaluated. Mean, standard deviation and median values were calculated for AMH and AFC by 1-year and 5-years intervals. Median age was 34.81 years, median AMH was 1.76ng/ml and median AFC was 11. From the total group, 40.60% presented with AMH levels below 1.3ng/mL. For women <45 years old, the decrease in AFC was between -0.6/-0.8 per year. Up to 36 years old, the decrease of AMH was 0.1ng/ml. However, from 36 to 40 years old, an accelerated decline of 0.23ng/ml yearly was noted. In keeping with local customs, 71.23% of women wore the hijab and 25.76% the niqab. AMH and AFC were significantly lower for niqab group compared with hijab group (p=0.02 and p=0.04, respectively).ConclusionThis is to-date the largest data set on age-specific AMH and AFC values in women from the Arabian Peninsula aiming to increase clinical awareness of the ovarian reserve in this population.https://www.frontiersin.org/articles/10.3389/fendo.2021.735116/fullAnti-Müllerian hormoneantral follicle countArab Peninsulaovarian reserveethnic |
| spellingShingle | Laura Melado Raquel Vitorino Carol Coughlan Leyla Depret Bixio Ana Arnanz Ana Arnanz Ibrahim Elkhatib Neelke De Munck Human M. Fatemi Barbara Lawrenz Barbara Lawrenz Ethnic and Sociocultural Differences in Ovarian Reserve: Age-Specific Anti-Müllerian Hormone Values and Antral Follicle Count for Women of the Arabian Peninsula Frontiers in Endocrinology Anti-Müllerian hormone antral follicle count Arab Peninsula ovarian reserve ethnic |
| title | Ethnic and Sociocultural Differences in Ovarian Reserve: Age-Specific Anti-Müllerian Hormone Values and Antral Follicle Count for Women of the Arabian Peninsula |
| title_full | Ethnic and Sociocultural Differences in Ovarian Reserve: Age-Specific Anti-Müllerian Hormone Values and Antral Follicle Count for Women of the Arabian Peninsula |
| title_fullStr | Ethnic and Sociocultural Differences in Ovarian Reserve: Age-Specific Anti-Müllerian Hormone Values and Antral Follicle Count for Women of the Arabian Peninsula |
| title_full_unstemmed | Ethnic and Sociocultural Differences in Ovarian Reserve: Age-Specific Anti-Müllerian Hormone Values and Antral Follicle Count for Women of the Arabian Peninsula |
| title_short | Ethnic and Sociocultural Differences in Ovarian Reserve: Age-Specific Anti-Müllerian Hormone Values and Antral Follicle Count for Women of the Arabian Peninsula |
| title_sort | ethnic and sociocultural differences in ovarian reserve age specific anti mullerian hormone values and antral follicle count for women of the arabian peninsula |
| topic | Anti-Müllerian hormone antral follicle count Arab Peninsula ovarian reserve ethnic |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.735116/full |
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