Strategies for the Biofunctionalization of Straining Flow Spinning Regenerated <i>Bombyx mori</i> Fibers
High-performance regenerated silkworm (<i>Bombyx mori</i>) silk fibers can be produced efficiently through the straining flow spinning (SFS) technique. In addition to an enhanced biocompatibility that results from the removal of contaminants during the processing of the material, regener...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/13/4146 |
| _version_ | 1797408546443231232 |
|---|---|
| author | Paloma Lozano-Picazo Cristina Castro-Domínguez Augusto Luis Bruno Alejandro Baeza Adelia S. Martínez Patricia A. López Ángela Castro Yassmin Lakhal Elena Montero Luis Colchero Daniel González-Nieto Francisco Javier Rojo Fivos Panetsos Milagros Ramos Rafael Daza Alfonso M. Gañán-Calvo Manuel Elices Gustavo Víctor Guinea José Pérez-Rigueiro |
| author_facet | Paloma Lozano-Picazo Cristina Castro-Domínguez Augusto Luis Bruno Alejandro Baeza Adelia S. Martínez Patricia A. López Ángela Castro Yassmin Lakhal Elena Montero Luis Colchero Daniel González-Nieto Francisco Javier Rojo Fivos Panetsos Milagros Ramos Rafael Daza Alfonso M. Gañán-Calvo Manuel Elices Gustavo Víctor Guinea José Pérez-Rigueiro |
| author_sort | Paloma Lozano-Picazo |
| collection | DOAJ |
| description | High-performance regenerated silkworm (<i>Bombyx mori</i>) silk fibers can be produced efficiently through the straining flow spinning (SFS) technique. In addition to an enhanced biocompatibility that results from the removal of contaminants during the processing of the material, regenerated silk fibers may be functionalized conveniently by using a range of different strategies. In this work, the possibility of implementing various functionalization techniques is explored, including the production of fluorescent fibers that may be tracked when implanted, the combination of the fibers with enzymes to yield fibers with catalytic properties, and the functionalization of the fibers with cell-adhesion motifs to modulate the adherence of different cell lineages to the material. When considered globally, all these techniques are a strong indication not only of the high versatility offered by the functionalization of regenerated fibers in terms of the different chemistries that can be employed, but also on the wide range of applications that can be covered with these functionalized fibers. |
| first_indexed | 2024-03-09T04:00:04Z |
| format | Article |
| id | doaj.art-03b787a17e374a279b3c4255186e8bab |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:00:04Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-03b787a17e374a279b3c4255186e8bab2023-12-03T14:13:33ZengMDPI AGMolecules1420-30492022-06-012713414610.3390/molecules27134146Strategies for the Biofunctionalization of Straining Flow Spinning Regenerated <i>Bombyx mori</i> FibersPaloma Lozano-Picazo0Cristina Castro-Domínguez1Augusto Luis Bruno2Alejandro Baeza3Adelia S. Martínez4Patricia A. López5Ángela Castro6Yassmin Lakhal7Elena Montero8Luis Colchero9Daniel González-Nieto10Francisco Javier Rojo11Fivos Panetsos12Milagros Ramos13Rafael Daza14Alfonso M. Gañán-Calvo15Manuel Elices16Gustavo Víctor Guinea17José Pérez-Rigueiro18Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainDepartamento de Materiales y Producción Aeroespacial, ETSI Aeronautical and Space Engineering, Universidad Politécnica de Madrid, 28040 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainNeuro-Computing and Neuro-Robotics Research Group, Complutense University of Madrid, 28037 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainDepartamento de Ingeniería Aeroespacial y Mecánica de Fluidos, ETSI, Universidad de Sevilla, Camino de los Descubrimientos, 41092 Sevilla, SpainDepartamento de Ciencia de Materiales, ETSI Caminos, Canales y Puertos, Universidad Politécnica de Madrid, 28040 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainCentro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, SpainHigh-performance regenerated silkworm (<i>Bombyx mori</i>) silk fibers can be produced efficiently through the straining flow spinning (SFS) technique. In addition to an enhanced biocompatibility that results from the removal of contaminants during the processing of the material, regenerated silk fibers may be functionalized conveniently by using a range of different strategies. In this work, the possibility of implementing various functionalization techniques is explored, including the production of fluorescent fibers that may be tracked when implanted, the combination of the fibers with enzymes to yield fibers with catalytic properties, and the functionalization of the fibers with cell-adhesion motifs to modulate the adherence of different cell lineages to the material. When considered globally, all these techniques are a strong indication not only of the high versatility offered by the functionalization of regenerated fibers in terms of the different chemistries that can be employed, but also on the wide range of applications that can be covered with these functionalized fibers.https://www.mdpi.com/1420-3049/27/13/4146silkfunctionalizationfluorophorestreptavidinbiotinclick chemistry |
| spellingShingle | Paloma Lozano-Picazo Cristina Castro-Domínguez Augusto Luis Bruno Alejandro Baeza Adelia S. Martínez Patricia A. López Ángela Castro Yassmin Lakhal Elena Montero Luis Colchero Daniel González-Nieto Francisco Javier Rojo Fivos Panetsos Milagros Ramos Rafael Daza Alfonso M. Gañán-Calvo Manuel Elices Gustavo Víctor Guinea José Pérez-Rigueiro Strategies for the Biofunctionalization of Straining Flow Spinning Regenerated <i>Bombyx mori</i> Fibers Molecules silk functionalization fluorophore streptavidin biotin click chemistry |
| title | Strategies for the Biofunctionalization of Straining Flow Spinning Regenerated <i>Bombyx mori</i> Fibers |
| title_full | Strategies for the Biofunctionalization of Straining Flow Spinning Regenerated <i>Bombyx mori</i> Fibers |
| title_fullStr | Strategies for the Biofunctionalization of Straining Flow Spinning Regenerated <i>Bombyx mori</i> Fibers |
| title_full_unstemmed | Strategies for the Biofunctionalization of Straining Flow Spinning Regenerated <i>Bombyx mori</i> Fibers |
| title_short | Strategies for the Biofunctionalization of Straining Flow Spinning Regenerated <i>Bombyx mori</i> Fibers |
| title_sort | strategies for the biofunctionalization of straining flow spinning regenerated i bombyx mori i fibers |
| topic | silk functionalization fluorophore streptavidin biotin click chemistry |
| url | https://www.mdpi.com/1420-3049/27/13/4146 |
| work_keys_str_mv | AT palomalozanopicazo strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT cristinacastrodominguez strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT augustoluisbruno strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT alejandrobaeza strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT adeliasmartinez strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT patriciaalopez strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT angelacastro strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT yassminlakhal strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT elenamontero strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT luiscolchero strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT danielgonzaleznieto strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT franciscojavierrojo strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT fivospanetsos strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT milagrosramos strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT rafaeldaza strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT alfonsomganancalvo strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT manuelelices strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT gustavovictorguinea strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers AT joseperezrigueiro strategiesforthebiofunctionalizationofstrainingflowspinningregeneratedibombyxmoriifibers |