Sevoflurane and Desflurane Exposures Following Aneurysmal Subarachnoid Hemorrhage Confer Multifaceted Protection against Delayed Cerebral Ischemia
Numerous studies have demonstrated the ability of isoflurane conditioning to provide multifaceted protection against aneurysmal subarachnoid hemorrhage (SAH)-associated delayed cerebral ischemia (DCI); however, preclinical studies have not yet examined whether other commonly used inhalational anesth...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/7/820 |
| _version_ | 1827687839502958592 |
|---|---|
| author | Keshav Jayaraman Meizi Liu Gregory J. Zipfel Umeshkumar Athiraman |
| author_facet | Keshav Jayaraman Meizi Liu Gregory J. Zipfel Umeshkumar Athiraman |
| author_sort | Keshav Jayaraman |
| collection | DOAJ |
| description | Numerous studies have demonstrated the ability of isoflurane conditioning to provide multifaceted protection against aneurysmal subarachnoid hemorrhage (SAH)-associated delayed cerebral ischemia (DCI); however, preclinical studies have not yet examined whether other commonly used inhalational anesthetics in neurological patients such as sevoflurane or desflurane are also protective against SAH-induced neurovascular deficits. We therefore sought to identify the potential for sevoflurane and desflurane conditioning to protect against DCI in an endovascular perforation mouse model of SAH. Neurological function was assessed daily via neuroscore. Large artery vasospasm and microvessel thrombosis were assessed three days after SAH or sham surgery. Four groups were examined: Sham, SAH + room air, SAH + 2% Sevoflurane, and SAH + 6% Desflurane. For the SAH groups, one hour after surgery, mice received 2% sevoflurane, 6% desflurane, or room air for one hour. We found that conditioning with sevoflurane or desflurane attenuated large artery vasospasm, reduced microvessel thrombosis, and improved neurologic function. Given their frequent clinical use and strong safety profile in patients (including those with SAH), these data strongly support further studies to validate these findings in preclinical and clinical studies and to elucidate the mechanisms by which these agents might be acting. |
| first_indexed | 2024-03-10T09:44:37Z |
| format | Article |
| id | doaj.art-03b9559abea34ac78b7f0587caf48604 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T09:44:37Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-03b9559abea34ac78b7f0587caf486042023-11-22T03:17:33ZengMDPI AGBiomedicines2227-90592021-07-019782010.3390/biomedicines9070820Sevoflurane and Desflurane Exposures Following Aneurysmal Subarachnoid Hemorrhage Confer Multifaceted Protection against Delayed Cerebral IschemiaKeshav Jayaraman0Meizi Liu1Gregory J. Zipfel2Umeshkumar Athiraman3Department of Anesthesiology, Washington University in Saint Louis, Saint Louis, MO 63110, USADepartment of Anesthesiology, Washington University in Saint Louis, Saint Louis, MO 63110, USADepartment of Neurological Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USADepartment of Anesthesiology, Washington University in Saint Louis, Saint Louis, MO 63110, USANumerous studies have demonstrated the ability of isoflurane conditioning to provide multifaceted protection against aneurysmal subarachnoid hemorrhage (SAH)-associated delayed cerebral ischemia (DCI); however, preclinical studies have not yet examined whether other commonly used inhalational anesthetics in neurological patients such as sevoflurane or desflurane are also protective against SAH-induced neurovascular deficits. We therefore sought to identify the potential for sevoflurane and desflurane conditioning to protect against DCI in an endovascular perforation mouse model of SAH. Neurological function was assessed daily via neuroscore. Large artery vasospasm and microvessel thrombosis were assessed three days after SAH or sham surgery. Four groups were examined: Sham, SAH + room air, SAH + 2% Sevoflurane, and SAH + 6% Desflurane. For the SAH groups, one hour after surgery, mice received 2% sevoflurane, 6% desflurane, or room air for one hour. We found that conditioning with sevoflurane or desflurane attenuated large artery vasospasm, reduced microvessel thrombosis, and improved neurologic function. Given their frequent clinical use and strong safety profile in patients (including those with SAH), these data strongly support further studies to validate these findings in preclinical and clinical studies and to elucidate the mechanisms by which these agents might be acting.https://www.mdpi.com/2227-9059/9/7/820inhalational anesthesiasevofluranedesfluraneconditioningdelayed cerebral ischemiaaneurysmal subarachnoid hemorrhage |
| spellingShingle | Keshav Jayaraman Meizi Liu Gregory J. Zipfel Umeshkumar Athiraman Sevoflurane and Desflurane Exposures Following Aneurysmal Subarachnoid Hemorrhage Confer Multifaceted Protection against Delayed Cerebral Ischemia Biomedicines inhalational anesthesia sevoflurane desflurane conditioning delayed cerebral ischemia aneurysmal subarachnoid hemorrhage |
| title | Sevoflurane and Desflurane Exposures Following Aneurysmal Subarachnoid Hemorrhage Confer Multifaceted Protection against Delayed Cerebral Ischemia |
| title_full | Sevoflurane and Desflurane Exposures Following Aneurysmal Subarachnoid Hemorrhage Confer Multifaceted Protection against Delayed Cerebral Ischemia |
| title_fullStr | Sevoflurane and Desflurane Exposures Following Aneurysmal Subarachnoid Hemorrhage Confer Multifaceted Protection against Delayed Cerebral Ischemia |
| title_full_unstemmed | Sevoflurane and Desflurane Exposures Following Aneurysmal Subarachnoid Hemorrhage Confer Multifaceted Protection against Delayed Cerebral Ischemia |
| title_short | Sevoflurane and Desflurane Exposures Following Aneurysmal Subarachnoid Hemorrhage Confer Multifaceted Protection against Delayed Cerebral Ischemia |
| title_sort | sevoflurane and desflurane exposures following aneurysmal subarachnoid hemorrhage confer multifaceted protection against delayed cerebral ischemia |
| topic | inhalational anesthesia sevoflurane desflurane conditioning delayed cerebral ischemia aneurysmal subarachnoid hemorrhage |
| url | https://www.mdpi.com/2227-9059/9/7/820 |
| work_keys_str_mv | AT keshavjayaraman sevofluraneanddesfluraneexposuresfollowinganeurysmalsubarachnoidhemorrhageconfermultifacetedprotectionagainstdelayedcerebralischemia AT meiziliu sevofluraneanddesfluraneexposuresfollowinganeurysmalsubarachnoidhemorrhageconfermultifacetedprotectionagainstdelayedcerebralischemia AT gregoryjzipfel sevofluraneanddesfluraneexposuresfollowinganeurysmalsubarachnoidhemorrhageconfermultifacetedprotectionagainstdelayedcerebralischemia AT umeshkumarathiraman sevofluraneanddesfluraneexposuresfollowinganeurysmalsubarachnoidhemorrhageconfermultifacetedprotectionagainstdelayedcerebralischemia |