YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts

YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts

Abstract Background Transcription factors YAP and TAZ function as the primary mediators of the Hippo pathway. Yet, crosstalk of YAP and TAZ with other signaling pathways remains relatively unexplored. We have explored the impact of YAP and TAZ levels on the TGF-β/Smad signaling pathway in human skin...

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Bibliographic Details
Main Authors: Zhaoping Qin, Wei Xia, Gary J. Fisher, John J. Voorhees, Taihao Quan
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Cell Communication and Signaling
Subjects:
YAP
TAZ
TGF-β/Smad
Smad7
Online Access:http://link.springer.com/article/10.1186/s12964-018-0232-3

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