Insulin Resistance in Gestational Diabetes Mellitus and Its Association With Anthropometric Fetal Indices
Background: In pregnant women with gestational diabetes mellitus (GDM), insulin resistance (IR) increases the risk of developing manifest type 2 diabetes mellitus and is associated with complications in both mother and fetus. Objectives: This research aimed to evaluate the associations between IR ev...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-05-01
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| Series: | Clinical Medicine Insights: Endocrinology and Diabetes |
| Online Access: | https://doi.org/10.1177/11795514221098403 |
| _version_ | 1818202865417584640 |
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| author | Tuan Dinh Le Tien Minh Bui Trinh Hien Vu Nga Phi Thi Nguyen Hoa Thanh Thi Tran Son Tien Nguyen Lan Ho Thi Nguyen Manh Van Ngo Hoang Huy Duong Binh Thanh Vu Hoa Trung Dinh Binh Nhu Do Duc-Cuong Le Hien Thi Nguyen Kien Trung Nguyen |
| author_facet | Tuan Dinh Le Tien Minh Bui Trinh Hien Vu Nga Phi Thi Nguyen Hoa Thanh Thi Tran Son Tien Nguyen Lan Ho Thi Nguyen Manh Van Ngo Hoang Huy Duong Binh Thanh Vu Hoa Trung Dinh Binh Nhu Do Duc-Cuong Le Hien Thi Nguyen Kien Trung Nguyen |
| author_sort | Tuan Dinh Le |
| collection | DOAJ |
| description | Background: In pregnant women with gestational diabetes mellitus (GDM), insulin resistance (IR) increases the risk of developing manifest type 2 diabetes mellitus and is associated with complications in both mother and fetus. Objectives: This research aimed to evaluate the associations between IR evaluated by 3 indices (namely updated homeostasis model assessment model (HOMA2), QUICKI, and McAuley’s index) and the diabetes risk factors and the fetal growth indices in Vietnamese women with GDM. Methods: A cross-sectional descriptive study was conducted on 370 women with GDM and 40 healthy pregnant women from January 2015 to May 2019. IR was calculated by HOMA2 (HOMA2-IR), QUICKI, and McAuley’s index. Fetal anthropometric measurements were assessed via ultrasound which was performed and interpreted by ultrasound experts. Results: In the simple regression analysis, McAuley’s index illustrated had statistically significant correlations to the highest number of risk factors of diabetes mellitus compared with HOMA2-IR and QUICKI indices. Moreover, McAuley’s index correlated statistically significantly to the highest number of fetal ultrasound measurements factors such as including biparietal diameter (BPD) ( r = −0.271, P < .001), head circumference (HC) ( r = −0.225, P < .001), abdominal circumference (AC) ( r = −0.214, P < .001), femur length (FL) ( r = −0.231, P < .001), estimated fetal weight (EFW) ( r = −0.239, P < .001) and fetal estimated age ( r = −0.299, P < .001). In the multivariable analysis, the McAuley’s index contributed the greatest to AC (Standardized B of −0.656, P < .001). Conclusion: The McAuley’s index was significantly associated with a higher number of more risk factors for diabetes mellitus as well as fetal ultrasound sonography findings measurements than compared with HOMA2-IR and QUICKI indices. |
| first_indexed | 2024-12-12T03:16:14Z |
| format | Article |
| id | doaj.art-03b9d95db7d541029e248567a1a0a39a |
| institution | Directory Open Access Journal |
| issn | 1179-5514 |
| language | English |
| last_indexed | 2024-12-12T03:16:14Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Endocrinology and Diabetes |
| spelling | doaj.art-03b9d95db7d541029e248567a1a0a39a2022-12-22T00:40:17ZengSAGE PublishingClinical Medicine Insights: Endocrinology and Diabetes1179-55142022-05-011510.1177/11795514221098403Insulin Resistance in Gestational Diabetes Mellitus and Its Association With Anthropometric Fetal IndicesTuan Dinh Le0Tien Minh Bui1Trinh Hien Vu2Nga Phi Thi Nguyen3Hoa Thanh Thi Tran4Son Tien Nguyen5Lan Ho Thi Nguyen6Manh Van Ngo7Hoang Huy Duong8Binh Thanh Vu9Hoa Trung Dinh10Binh Nhu Do11Duc-Cuong Le12Hien Thi Nguyen13Kien Trung Nguyen14Vietnam Military Medical University, Ha Noi, VietnamDepartment of Obstetrics and Gynecology, Thai Binh University of Medicine and Pharmacy, Thai Binh, VietnamNational Hospital of Endocrinology, Ha Noi, VietnamVietnam Military Medical University, Ha Noi, VietnamNational Hospital of Endocrinology, Ha Noi, VietnamVietnam Military Medical University, Ha Noi, VietnamNational Hospital of Endocrinology, Ha Noi, VietnamPostgraduate Training Management Department, Thai Binh University of Medicine and Pharmacy, Thai Binh, VietnamDepartment of Neurology, Thai Binh University of Medicine and Pharmacy, Thai Binh, VietnamDepartment of Internal Medicine, Thai Binh University of Medicine and Pharmacy, Thai Binh, VietnamDepartmen of Requested Treatment, National Hospital of Endocrinology, Ha Noi, VietnamDivision of Military Science, Military Hospital 103, Vietnam Military Medical University, Ha Noi, VietnamDepartment of Epidemiology, Thai Binh University of Medicine and Pharmacy, Thai Binh, VietnamDepartment of Physiology, Thai Binh University of Medicine and Pharmacy, Thai Binh, VietnamDepartment of Obstetrics and Gynecology, Thai Binh University of Medicine and Pharmacy, Thai Binh, VietnamBackground: In pregnant women with gestational diabetes mellitus (GDM), insulin resistance (IR) increases the risk of developing manifest type 2 diabetes mellitus and is associated with complications in both mother and fetus. Objectives: This research aimed to evaluate the associations between IR evaluated by 3 indices (namely updated homeostasis model assessment model (HOMA2), QUICKI, and McAuley’s index) and the diabetes risk factors and the fetal growth indices in Vietnamese women with GDM. Methods: A cross-sectional descriptive study was conducted on 370 women with GDM and 40 healthy pregnant women from January 2015 to May 2019. IR was calculated by HOMA2 (HOMA2-IR), QUICKI, and McAuley’s index. Fetal anthropometric measurements were assessed via ultrasound which was performed and interpreted by ultrasound experts. Results: In the simple regression analysis, McAuley’s index illustrated had statistically significant correlations to the highest number of risk factors of diabetes mellitus compared with HOMA2-IR and QUICKI indices. Moreover, McAuley’s index correlated statistically significantly to the highest number of fetal ultrasound measurements factors such as including biparietal diameter (BPD) ( r = −0.271, P < .001), head circumference (HC) ( r = −0.225, P < .001), abdominal circumference (AC) ( r = −0.214, P < .001), femur length (FL) ( r = −0.231, P < .001), estimated fetal weight (EFW) ( r = −0.239, P < .001) and fetal estimated age ( r = −0.299, P < .001). In the multivariable analysis, the McAuley’s index contributed the greatest to AC (Standardized B of −0.656, P < .001). Conclusion: The McAuley’s index was significantly associated with a higher number of more risk factors for diabetes mellitus as well as fetal ultrasound sonography findings measurements than compared with HOMA2-IR and QUICKI indices.https://doi.org/10.1177/11795514221098403 |
| spellingShingle | Tuan Dinh Le Tien Minh Bui Trinh Hien Vu Nga Phi Thi Nguyen Hoa Thanh Thi Tran Son Tien Nguyen Lan Ho Thi Nguyen Manh Van Ngo Hoang Huy Duong Binh Thanh Vu Hoa Trung Dinh Binh Nhu Do Duc-Cuong Le Hien Thi Nguyen Kien Trung Nguyen Insulin Resistance in Gestational Diabetes Mellitus and Its Association With Anthropometric Fetal Indices Clinical Medicine Insights: Endocrinology and Diabetes |
| title | Insulin Resistance in Gestational Diabetes Mellitus and Its Association With Anthropometric Fetal Indices |
| title_full | Insulin Resistance in Gestational Diabetes Mellitus and Its Association With Anthropometric Fetal Indices |
| title_fullStr | Insulin Resistance in Gestational Diabetes Mellitus and Its Association With Anthropometric Fetal Indices |
| title_full_unstemmed | Insulin Resistance in Gestational Diabetes Mellitus and Its Association With Anthropometric Fetal Indices |
| title_short | Insulin Resistance in Gestational Diabetes Mellitus and Its Association With Anthropometric Fetal Indices |
| title_sort | insulin resistance in gestational diabetes mellitus and its association with anthropometric fetal indices |
| url | https://doi.org/10.1177/11795514221098403 |
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