Identification of Sex-Specific Plasma Biomarkers Using Metabolomics for Major Depressive Disorder in Children and Adolescents
BackgroundChildren and adolescents are at a high risk of major depressive disorder (MDD) with known sex differences in epidemiology. However, there are currently no objective laboratory-based sex-specific biomarkers available to support the diagnoses of male and female patients with MDD.MethodsHere,...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.929207/full |
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| author | Yuanliang Jiang Yuanliang Jiang Mengchang Qin Mengchang Qin Teng Teng Teng Teng Xuemei Li Xuemei Li Ying Yu Ying Yu Jie Wang Jie Wang Hongyan Wu Hongyan Wu Yuqian He Yuqian He Xinyu Zhou Xinyu Zhou Peng Xie Peng Xie |
| author_facet | Yuanliang Jiang Yuanliang Jiang Mengchang Qin Mengchang Qin Teng Teng Teng Teng Xuemei Li Xuemei Li Ying Yu Ying Yu Jie Wang Jie Wang Hongyan Wu Hongyan Wu Yuqian He Yuqian He Xinyu Zhou Xinyu Zhou Peng Xie Peng Xie |
| author_sort | Yuanliang Jiang |
| collection | DOAJ |
| description | BackgroundChildren and adolescents are at a high risk of major depressive disorder (MDD) with known sex differences in epidemiology. However, there are currently no objective laboratory-based sex-specific biomarkers available to support the diagnoses of male and female patients with MDD.MethodsHere, a male set of 42 cases and 27 healthy controls (HCs) and a female set of 42 cases and 22 HCs were recruited. This study investigated the sex differences of plasma metabolite biomarkers in young patients with MDD by the application of ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry.ResultsThe metabolic profiles showed clear separations in both male and female sets. In total, this study identified 57 male-related and 53 female-related differential metabolites. Compared with HCs, both male and female subjects with MDD displayed four significantly altered pathways. Notably, biliverdin was selected as an independent diagnostic male-specific biomarker with an area under the receiver operating characteristic curve of 0.966, and phosphatidylcholine (10:0/14:1) was selected as a female-specific biomarker, achieving an area under the curve (AUC) of 0.957.ConclusionThis metabolomics study may aid in the development of a plasma-based test for the diagnosis of male and female children and adolescents with MDD, as well as give new insight into the pathophysiology of sex differences in children and adolescents with MDD. |
| first_indexed | 2024-04-12T09:11:04Z |
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| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-12T09:11:04Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-03ba03f955b241b290b191ae7e71a6202022-12-22T03:38:58ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-07-011310.3389/fpsyt.2022.929207929207Identification of Sex-Specific Plasma Biomarkers Using Metabolomics for Major Depressive Disorder in Children and AdolescentsYuanliang Jiang0Yuanliang Jiang1Mengchang Qin2Mengchang Qin3Teng Teng4Teng Teng5Xuemei Li6Xuemei Li7Ying Yu8Ying Yu9Jie Wang10Jie Wang11Hongyan Wu12Hongyan Wu13Yuqian He14Yuqian He15Xinyu Zhou16Xinyu Zhou17Peng Xie18Peng Xie19Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaBackgroundChildren and adolescents are at a high risk of major depressive disorder (MDD) with known sex differences in epidemiology. However, there are currently no objective laboratory-based sex-specific biomarkers available to support the diagnoses of male and female patients with MDD.MethodsHere, a male set of 42 cases and 27 healthy controls (HCs) and a female set of 42 cases and 22 HCs were recruited. This study investigated the sex differences of plasma metabolite biomarkers in young patients with MDD by the application of ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry.ResultsThe metabolic profiles showed clear separations in both male and female sets. In total, this study identified 57 male-related and 53 female-related differential metabolites. Compared with HCs, both male and female subjects with MDD displayed four significantly altered pathways. Notably, biliverdin was selected as an independent diagnostic male-specific biomarker with an area under the receiver operating characteristic curve of 0.966, and phosphatidylcholine (10:0/14:1) was selected as a female-specific biomarker, achieving an area under the curve (AUC) of 0.957.ConclusionThis metabolomics study may aid in the development of a plasma-based test for the diagnosis of male and female children and adolescents with MDD, as well as give new insight into the pathophysiology of sex differences in children and adolescents with MDD.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.929207/fullmajor depressive disorderchildren and adolescentssex specificbiomarkermetabolomicsplasma |
| spellingShingle | Yuanliang Jiang Yuanliang Jiang Mengchang Qin Mengchang Qin Teng Teng Teng Teng Xuemei Li Xuemei Li Ying Yu Ying Yu Jie Wang Jie Wang Hongyan Wu Hongyan Wu Yuqian He Yuqian He Xinyu Zhou Xinyu Zhou Peng Xie Peng Xie Identification of Sex-Specific Plasma Biomarkers Using Metabolomics for Major Depressive Disorder in Children and Adolescents Frontiers in Psychiatry major depressive disorder children and adolescents sex specific biomarker metabolomics plasma |
| title | Identification of Sex-Specific Plasma Biomarkers Using Metabolomics for Major Depressive Disorder in Children and Adolescents |
| title_full | Identification of Sex-Specific Plasma Biomarkers Using Metabolomics for Major Depressive Disorder in Children and Adolescents |
| title_fullStr | Identification of Sex-Specific Plasma Biomarkers Using Metabolomics for Major Depressive Disorder in Children and Adolescents |
| title_full_unstemmed | Identification of Sex-Specific Plasma Biomarkers Using Metabolomics for Major Depressive Disorder in Children and Adolescents |
| title_short | Identification of Sex-Specific Plasma Biomarkers Using Metabolomics for Major Depressive Disorder in Children and Adolescents |
| title_sort | identification of sex specific plasma biomarkers using metabolomics for major depressive disorder in children and adolescents |
| topic | major depressive disorder children and adolescents sex specific biomarker metabolomics plasma |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.929207/full |
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