Risk Factors Promoting Early Cardiovascular Structure Disorders in Patients with Primary Hypothyroidism
Objective. To develop the pattern of early cardiovascular disorders in patients with primary hypothyroidism based on the analysis of relationship between patient’s thyroid status and some functional cardiovascular parameters depending on compensation status. Materials and methods. The examination of...
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| Format: | Article |
| Language: | Russian |
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SINAPS LLC
2022-02-01
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| Series: | Архивъ внутренней медицины |
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| Online Access: | https://www.medarhive.ru/jour/article/view/1376 |
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| author | A. V. Nikolaeva L. T. Pimenov V. G. Sufiyanov M. V. Dudarev |
| author_facet | A. V. Nikolaeva L. T. Pimenov V. G. Sufiyanov M. V. Dudarev |
| author_sort | A. V. Nikolaeva |
| collection | DOAJ |
| description | Objective. To develop the pattern of early cardiovascular disorders in patients with primary hypothyroidism based on the analysis of relationship between patient’s thyroid status and some functional cardiovascular parameters depending on compensation status. Materials and methods. The examination of 163 women aged 62 [55;67] years with primary hypothyroidism was performed. The patients were divided into groups: 1 group included 54 patients aged 62.0 [57;68] years with subcompensated disease, 2 group consisted of 15 patients aged 59 [53;66] years with non-compensated disease and 3 group included 94 patients aged 63 [53;66] years with compensated hypothyroidism. Physical examination, transthoracic echocardiography, assessment of global left ventricle longitudinal strain by speckle tracking method, endothelial function and laboratory tests were performed to all patients. Regression analysis using thyroid stimulating hormone, free T4, age, duration of the disease, cause of hypothyroidism, menopause presence and natural thyroid stimulating hormone logarithm as predictors and some cardiovascular parameters of heart condition and lipid metabolism as dependent valuables was made. Results. Mathematic modeling demonstrated that the combination such factors as age, duration of disease and thyroid stimulating hormone level is the most important in left ventricle remodeling processes. However, the age only has significant influence on intima media thickness. Conclusion. Left ventricle remodeling, morphologic functional status of blood vessel wall and decrease of glomerular filtration rate are basically determined by such modified and non-modified factors as body mass index, age, duration of hypothyroidism and thyroid stimulating hormone level. |
| first_indexed | 2024-04-10T03:55:35Z |
| format | Article |
| id | doaj.art-03bbca79c5f14a5dbf87c6126527a397 |
| institution | Directory Open Access Journal |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| last_indexed | 2024-04-10T03:55:35Z |
| publishDate | 2022-02-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj.art-03bbca79c5f14a5dbf87c6126527a3972023-03-13T07:12:10ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642022-02-01121536110.20514/2226-6704-2022-12-1-53-61878Risk Factors Promoting Early Cardiovascular Structure Disorders in Patients with Primary HypothyroidismA. V. Nikolaeva0L. T. Pimenov1V. G. Sufiyanov2M. V. Dudarev3ФГБУ ВО «Ижевская государственная медицинская академия» МЗ РФФГБУ ВО «Ижевская государственная медицинская академия» МЗ РФФГБОУ ВО «Ижевский государственный технический университет имени М. Т. Калашникова»ФГБУ ВО «Ижевская государственная медицинская академия» МЗ РФObjective. To develop the pattern of early cardiovascular disorders in patients with primary hypothyroidism based on the analysis of relationship between patient’s thyroid status and some functional cardiovascular parameters depending on compensation status. Materials and methods. The examination of 163 women aged 62 [55;67] years with primary hypothyroidism was performed. The patients were divided into groups: 1 group included 54 patients aged 62.0 [57;68] years with subcompensated disease, 2 group consisted of 15 patients aged 59 [53;66] years with non-compensated disease and 3 group included 94 patients aged 63 [53;66] years with compensated hypothyroidism. Physical examination, transthoracic echocardiography, assessment of global left ventricle longitudinal strain by speckle tracking method, endothelial function and laboratory tests were performed to all patients. Regression analysis using thyroid stimulating hormone, free T4, age, duration of the disease, cause of hypothyroidism, menopause presence and natural thyroid stimulating hormone logarithm as predictors and some cardiovascular parameters of heart condition and lipid metabolism as dependent valuables was made. Results. Mathematic modeling demonstrated that the combination such factors as age, duration of disease and thyroid stimulating hormone level is the most important in left ventricle remodeling processes. However, the age only has significant influence on intima media thickness. Conclusion. Left ventricle remodeling, morphologic functional status of blood vessel wall and decrease of glomerular filtration rate are basically determined by such modified and non-modified factors as body mass index, age, duration of hypothyroidism and thyroid stimulating hormone level.https://www.medarhive.ru/jour/article/view/1376первичный гипотиреозмодель поражения сердцаремоделирование левого желудочкалипидный обмен |
| spellingShingle | A. V. Nikolaeva L. T. Pimenov V. G. Sufiyanov M. V. Dudarev Risk Factors Promoting Early Cardiovascular Structure Disorders in Patients with Primary Hypothyroidism Архивъ внутренней медицины первичный гипотиреоз модель поражения сердца ремоделирование левого желудочка липидный обмен |
| title | Risk Factors Promoting Early Cardiovascular Structure Disorders in Patients with Primary Hypothyroidism |
| title_full | Risk Factors Promoting Early Cardiovascular Structure Disorders in Patients with Primary Hypothyroidism |
| title_fullStr | Risk Factors Promoting Early Cardiovascular Structure Disorders in Patients with Primary Hypothyroidism |
| title_full_unstemmed | Risk Factors Promoting Early Cardiovascular Structure Disorders in Patients with Primary Hypothyroidism |
| title_short | Risk Factors Promoting Early Cardiovascular Structure Disorders in Patients with Primary Hypothyroidism |
| title_sort | risk factors promoting early cardiovascular structure disorders in patients with primary hypothyroidism |
| topic | первичный гипотиреоз модель поражения сердца ремоделирование левого желудочка липидный обмен |
| url | https://www.medarhive.ru/jour/article/view/1376 |
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