Evaluation of SCUBE-1 Level and Carotid Intima Media Thickness in Recurrent Pregnancy Loss
INTRODUCTION: Evaluation of the signal peptide complement C1r/C1s, Uegf, and Bmp1 (CUB), and epidermal growth factor-like domain-containing protein-1 (SCUBE-1) levels and carotid intima media thickness (CIMT) between the group of patients with and without recurrent pregnancy loss (RPL). METHODS: Thi...
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| Format: | Article |
| Language: | English |
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Ankara Yildirim Beyazit University
2020-09-01
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| Series: | Ankara Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-59254 |
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| author | Sabri Colak Emine Seda Guvendag Guven Suleyman Guven Turan Erdogan Yeşim Bayoglu Tekin Funda Akpınar |
| author_facet | Sabri Colak Emine Seda Guvendag Guven Suleyman Guven Turan Erdogan Yeşim Bayoglu Tekin Funda Akpınar |
| author_sort | Sabri Colak |
| collection | DOAJ |
| description | INTRODUCTION: Evaluation of the signal peptide complement C1r/C1s, Uegf, and Bmp1 (CUB), and epidermal growth factor-like domain-containing protein-1 (SCUBE-1) levels and carotid intima media thickness (CIMT) between the group of patients with and without recurrent pregnancy loss (RPL). METHODS: This prospective and single-center study included 20-40-year-old 30 patients with and 30 patients without a history of RPL. No patients with any anatomical, hereditary, or endocrinological thrombophilic defects were included. Comparison of SCUBE-1 levels and CIMT were made between the patient and control groups. RESULTS: There were no statistically significant differences between patients and control groups in terms of demographic characteristics except for gravidity, parity and miscarriages.The mean SCUBE-1 level in the RPL group was statistically significantly higher compared to the control group (16.44+-5.43 vs.10.17+-5.19, respectively, p=0.001). The mean CIMT value in RPL patients was statistically significantly higher than that of the control group (0.60+-0.09 vs.0.44+-0.07, respectively, p=0.001). DISCUSSION AND CONCLUSION: High levels of serum SCUBE-1 and CIMT in RPL may suggest that ischemia and endothelial dysfunction may be involved in the etiology of RPL. Future studies may shed light on the diagnosis, treatment, and management of RPL. |
| first_indexed | 2024-04-10T10:42:52Z |
| format | Article |
| id | doaj.art-03bd2508a6204684a1f7303dec227345 |
| institution | Directory Open Access Journal |
| issn | 2148-4570 |
| language | English |
| last_indexed | 2024-04-10T10:42:52Z |
| publishDate | 2020-09-01 |
| publisher | Ankara Yildirim Beyazit University |
| record_format | Article |
| series | Ankara Medical Journal |
| spelling | doaj.art-03bd2508a6204684a1f7303dec2273452023-02-15T16:20:25ZengAnkara Yildirim Beyazit UniversityAnkara Medical Journal2148-45702020-09-0120373074210.5505/amj.2020.59254AMJ-59254Evaluation of SCUBE-1 Level and Carotid Intima Media Thickness in Recurrent Pregnancy LossSabri Colak0Emine Seda Guvendag Guven1Suleyman Guven2Turan Erdogan3Yeşim Bayoglu Tekin4Funda Akpınar5Department of Obstetrics and Gynecology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.Department of Gynecology and Obstetrics, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeyDepartment of Gynecology and Obstetrics, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeyDepartment of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, TurkeyDepartment of Gynecology and Obstetrics, Sağlık Bilimleri University, School of Medicine, İstanbul, TurkeyDepartment of Gynecology and Obstetrics, University of Health Sciences, Ankara Etlik Zübeyde Hanım Training and Research Hospital, Ankara, TurkeyINTRODUCTION: Evaluation of the signal peptide complement C1r/C1s, Uegf, and Bmp1 (CUB), and epidermal growth factor-like domain-containing protein-1 (SCUBE-1) levels and carotid intima media thickness (CIMT) between the group of patients with and without recurrent pregnancy loss (RPL). METHODS: This prospective and single-center study included 20-40-year-old 30 patients with and 30 patients without a history of RPL. No patients with any anatomical, hereditary, or endocrinological thrombophilic defects were included. Comparison of SCUBE-1 levels and CIMT were made between the patient and control groups. RESULTS: There were no statistically significant differences between patients and control groups in terms of demographic characteristics except for gravidity, parity and miscarriages.The mean SCUBE-1 level in the RPL group was statistically significantly higher compared to the control group (16.44+-5.43 vs.10.17+-5.19, respectively, p=0.001). The mean CIMT value in RPL patients was statistically significantly higher than that of the control group (0.60+-0.09 vs.0.44+-0.07, respectively, p=0.001). DISCUSSION AND CONCLUSION: High levels of serum SCUBE-1 and CIMT in RPL may suggest that ischemia and endothelial dysfunction may be involved in the etiology of RPL. Future studies may shed light on the diagnosis, treatment, and management of RPL.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-59254abortionhabitualscube1 proteincarotid intima-media thickness |
| spellingShingle | Sabri Colak Emine Seda Guvendag Guven Suleyman Guven Turan Erdogan Yeşim Bayoglu Tekin Funda Akpınar Evaluation of SCUBE-1 Level and Carotid Intima Media Thickness in Recurrent Pregnancy Loss Ankara Medical Journal abortion habitual scube1 protein carotid intima-media thickness |
| title | Evaluation of SCUBE-1 Level and Carotid Intima Media Thickness in Recurrent Pregnancy Loss |
| title_full | Evaluation of SCUBE-1 Level and Carotid Intima Media Thickness in Recurrent Pregnancy Loss |
| title_fullStr | Evaluation of SCUBE-1 Level and Carotid Intima Media Thickness in Recurrent Pregnancy Loss |
| title_full_unstemmed | Evaluation of SCUBE-1 Level and Carotid Intima Media Thickness in Recurrent Pregnancy Loss |
| title_short | Evaluation of SCUBE-1 Level and Carotid Intima Media Thickness in Recurrent Pregnancy Loss |
| title_sort | evaluation of scube 1 level and carotid intima media thickness in recurrent pregnancy loss |
| topic | abortion habitual scube1 protein carotid intima-media thickness |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-59254 |
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