Long-term outcomes of combined radiofrequency ablation and multipronged ethanol ablation for the treatment of unfavorable hepatocellular carcinoma
PURPOSETo evaluate the local efficacy, safety, and long-term outcomes of combined radiofrequency ablation (RFA) and multipronged ethanol ablation (EA) in the treatment of unfavorable hepatocellular carcinoma (HCC) and to determine the prognostic factors for survival.METHODSBetween August 2009 and De...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2023-03-01
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| Series: | Diagnostic and Interventional Radiology |
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| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/long-term-outcomes-of-combined-radiofrequency-abla/57321
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| _version_ | 1797691400659140608 |
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| author | Ming Liu Xiao-Ju Li Xiao-Er Zhang Ming Kuang Xiao-Yan Xie Guang-Liang Huang |
| author_facet | Ming Liu Xiao-Ju Li Xiao-Er Zhang Ming Kuang Xiao-Yan Xie Guang-Liang Huang |
| author_sort | Ming Liu |
| collection | DOAJ |
| description | PURPOSETo evaluate the local efficacy, safety, and long-term outcomes of combined radiofrequency ablation (RFA) and multipronged ethanol ablation (EA) in the treatment of unfavorable hepatocellular carcinoma (HCC) and to determine the prognostic factors for survival.METHODSBetween August 2009 and December 2017, 98 patients with 110 unfavorable HCC nodules who underwent combined RFA and multipronged EA were retrospectively enrolled in the study. Unfavorable HCC was defined as a medium (3.1–5.0 cm) or large (5.1–7.0 cm) HCC nodule, a tumor located at a high-risk site, or a perivascular tumor. The treatment response, overall survival (OS), and recurrence-free survival (RFS) were analyzed. The Kaplan–Meier method and Cox proportional hazards regression model were used to evaluate the prognostic factors.RESULTSComplete ablation was obtained in 80.9% (89/110) of the tumors after initial treatment. Major complications were observed in 3 (3.1%) patients. The cumulative incidence of local tumor progression (LTP) was 23.5% at five years, and no variable was found to be an independent predictive factor for LTP. The five-year OS and RFS rates were 41.9% and 34.0%, respectively. Multivariate analysis showed that the serum alpha-fetoprotein level, tumor size, presence of residual tumor after ablation, and extrahepatic metastases were significant prognostic factors for OS (P = 0.023, P = 0.030, P = 0.001, and P = 0.010, respectively). Tumor type and the number of tumors were predictive factors for RFS (P = 0.029 and P = 0.001, respectively). A perivascular tumor was not an independent predictive factor for OS or RFS.CONCLUSIONCombined RFA and multipronged EA is a safe and effective treatment for unfavorable HCC, especially for perivascular tumors. |
| first_indexed | 2024-03-12T02:12:46Z |
| format | Article |
| id | doaj.art-03becb7cf6a34f67b2dd483fe16d05c4 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:12:46Z |
| publishDate | 2023-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-03becb7cf6a34f67b2dd483fe16d05c42023-09-06T11:54:11ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122023-03-0129234234910.4274/dir.2022.2283213049054Long-term outcomes of combined radiofrequency ablation and multipronged ethanol ablation for the treatment of unfavorable hepatocellular carcinomaMing Liu0Xiao-Ju Li1Xiao-Er Zhang2Ming Kuang3Xiao-Yan Xie4Guang-Liang Huang5 Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-Sen University, Institute for Diagnostic and Interventional Ultrasound, Guangzhou, China Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-Sen University, Institute for Diagnostic and Interventional Ultrasound, Guangzhou, China Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-Sen University, Institute for Diagnostic and Interventional Ultrasound, Guangzhou, China Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-Sen University, Institute for Diagnostic and Interventional Ultrasound, Guangzhou, China Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-Sen University, Institute for Diagnostic and Interventional Ultrasound, Guangzhou, China Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-Sen University, Institute for Diagnostic and Interventional Ultrasound, Guangzhou, China PURPOSETo evaluate the local efficacy, safety, and long-term outcomes of combined radiofrequency ablation (RFA) and multipronged ethanol ablation (EA) in the treatment of unfavorable hepatocellular carcinoma (HCC) and to determine the prognostic factors for survival.METHODSBetween August 2009 and December 2017, 98 patients with 110 unfavorable HCC nodules who underwent combined RFA and multipronged EA were retrospectively enrolled in the study. Unfavorable HCC was defined as a medium (3.1–5.0 cm) or large (5.1–7.0 cm) HCC nodule, a tumor located at a high-risk site, or a perivascular tumor. The treatment response, overall survival (OS), and recurrence-free survival (RFS) were analyzed. The Kaplan–Meier method and Cox proportional hazards regression model were used to evaluate the prognostic factors.RESULTSComplete ablation was obtained in 80.9% (89/110) of the tumors after initial treatment. Major complications were observed in 3 (3.1%) patients. The cumulative incidence of local tumor progression (LTP) was 23.5% at five years, and no variable was found to be an independent predictive factor for LTP. The five-year OS and RFS rates were 41.9% and 34.0%, respectively. Multivariate analysis showed that the serum alpha-fetoprotein level, tumor size, presence of residual tumor after ablation, and extrahepatic metastases were significant prognostic factors for OS (P = 0.023, P = 0.030, P = 0.001, and P = 0.010, respectively). Tumor type and the number of tumors were predictive factors for RFS (P = 0.029 and P = 0.001, respectively). A perivascular tumor was not an independent predictive factor for OS or RFS.CONCLUSIONCombined RFA and multipronged EA is a safe and effective treatment for unfavorable HCC, especially for perivascular tumors. http://www.dirjournal.org/archives/archive-detail/article-preview/long-term-outcomes-of-combined-radiofrequency-abla/57321 combineethanolhepatocellular carcinomaradiofrequency ablationsurvival |
| spellingShingle | Ming Liu Xiao-Ju Li Xiao-Er Zhang Ming Kuang Xiao-Yan Xie Guang-Liang Huang Long-term outcomes of combined radiofrequency ablation and multipronged ethanol ablation for the treatment of unfavorable hepatocellular carcinoma Diagnostic and Interventional Radiology combine ethanol hepatocellular carcinoma radiofrequency ablation survival |
| title | Long-term outcomes of combined radiofrequency ablation and multipronged ethanol ablation for the treatment of unfavorable hepatocellular carcinoma |
| title_full | Long-term outcomes of combined radiofrequency ablation and multipronged ethanol ablation for the treatment of unfavorable hepatocellular carcinoma |
| title_fullStr | Long-term outcomes of combined radiofrequency ablation and multipronged ethanol ablation for the treatment of unfavorable hepatocellular carcinoma |
| title_full_unstemmed | Long-term outcomes of combined radiofrequency ablation and multipronged ethanol ablation for the treatment of unfavorable hepatocellular carcinoma |
| title_short | Long-term outcomes of combined radiofrequency ablation and multipronged ethanol ablation for the treatment of unfavorable hepatocellular carcinoma |
| title_sort | long term outcomes of combined radiofrequency ablation and multipronged ethanol ablation for the treatment of unfavorable hepatocellular carcinoma |
| topic | combine ethanol hepatocellular carcinoma radiofrequency ablation survival |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/long-term-outcomes-of-combined-radiofrequency-abla/57321
|
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