The Effect of Resistance Training on Malondialdehyde and Protein Carbonyl Concentration in the Heart Tissue of Rats Exposed to Stanozolol
Background: Consumption of anabolic steroids causes damage to various tissues, including the heart. Objectives: This study aimed to investigate the effect of Resistance Training (RT) on Malondialdehyde (MDA) and Protein Carbonyl (PC) in the heart tissue of rats exposed to stanozolol (S). Methods:...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2020-12-01
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| Series: | Pharmaceutical and Biomedical Research |
| Subjects: | |
| Online Access: | http://pbr.mazums.ac.ir/article-1-321-en.html |
| _version_ | 1818965753439715328 |
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| author | Ayat Arjmand Bahram Abedi Ali Hosseini |
| author_facet | Ayat Arjmand Bahram Abedi Ali Hosseini |
| author_sort | Ayat Arjmand |
| collection | DOAJ |
| description | Background: Consumption of anabolic steroids causes damage to various tissues, including the heart.
Objectives: This study aimed to investigate the effect of Resistance Training (RT) on Malondialdehyde (MDA) and Protein Carbonyl (PC) in the heart tissue of rats exposed to stanozolol (S).
Methods: In this experimental study, 18 rats with the mean age of 8 weeks and weight range of 150 to 200 g were selected and divided into three groups of 6 rats: 1. Sham (normal saline consumption) (Sh), 2. S, and 3. S+RT. For 8 weeks, the S and S+RT groups received 5 mg/kg/d S, and the S+RT group performed 5 RT sessions per week. Measurement of MDA and PC in the heart tissue was performed with the enzyme-linked immunosorbent assay.
Results: Stanozolol had a significant effect on increasing MAD (P=0.001) and PC (P=0.03) in the heart tissue. However, RT led to a decrease in MDA and PC in the heart tissue of rats exposed to S (P=0.001).
Conclusion: It appears that S consumption leads to an increase in MDA and PC levels in the heart tissue, while RT can improve the elevated levels of MDA and PC. |
| first_indexed | 2024-12-20T13:22:01Z |
| format | Article |
| id | doaj.art-03bece6f85254290956988c082eb0e33 |
| institution | Directory Open Access Journal |
| issn | 2423-4494 |
| language | English |
| last_indexed | 2024-12-20T13:22:01Z |
| publishDate | 2020-12-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-03bece6f85254290956988c082eb0e332022-12-21T19:39:22ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44942020-12-016426126810.18502/pbr.v6i4.5112The Effect of Resistance Training on Malondialdehyde and Protein Carbonyl Concentration in the Heart Tissue of Rats Exposed to StanozololAyat Arjmand0https://orcid.org/0000-0003-1708-5330Bahram Abedi1https://orcid.org/0000-0002-6858-5469Ali Hosseini2https://orcid.org/0000-0001-9122-3952Department of Physical Education and Sport Sciences, Faculty of Human Science, Mahallat Branch, Islamic Azad University, Mahallat, IranDepartment of Physical Education and Sport Sciences, Faculty of Human Science, Mahallat Branch, Islamic Azad University, Mahallat, IranDepartment of Sport Physiology, Faculty of Human Science, Marvdasht Branch, Islamic Azad University, Marvdasht, IranBackground: Consumption of anabolic steroids causes damage to various tissues, including the heart. Objectives: This study aimed to investigate the effect of Resistance Training (RT) on Malondialdehyde (MDA) and Protein Carbonyl (PC) in the heart tissue of rats exposed to stanozolol (S). Methods: In this experimental study, 18 rats with the mean age of 8 weeks and weight range of 150 to 200 g were selected and divided into three groups of 6 rats: 1. Sham (normal saline consumption) (Sh), 2. S, and 3. S+RT. For 8 weeks, the S and S+RT groups received 5 mg/kg/d S, and the S+RT group performed 5 RT sessions per week. Measurement of MDA and PC in the heart tissue was performed with the enzyme-linked immunosorbent assay. Results: Stanozolol had a significant effect on increasing MAD (P=0.001) and PC (P=0.03) in the heart tissue. However, RT led to a decrease in MDA and PC in the heart tissue of rats exposed to S (P=0.001). Conclusion: It appears that S consumption leads to an increase in MDA and PC levels in the heart tissue, while RT can improve the elevated levels of MDA and PC.http://pbr.mazums.ac.ir/article-1-321-en.htmlmalondialdehydeprotein carbonylresistance trainingstanazololheart |
| spellingShingle | Ayat Arjmand Bahram Abedi Ali Hosseini The Effect of Resistance Training on Malondialdehyde and Protein Carbonyl Concentration in the Heart Tissue of Rats Exposed to Stanozolol Pharmaceutical and Biomedical Research malondialdehyde protein carbonyl resistance training stanazolol heart |
| title | The Effect of Resistance Training on Malondialdehyde and Protein Carbonyl Concentration in the Heart Tissue of Rats Exposed to Stanozolol |
| title_full | The Effect of Resistance Training on Malondialdehyde and Protein Carbonyl Concentration in the Heart Tissue of Rats Exposed to Stanozolol |
| title_fullStr | The Effect of Resistance Training on Malondialdehyde and Protein Carbonyl Concentration in the Heart Tissue of Rats Exposed to Stanozolol |
| title_full_unstemmed | The Effect of Resistance Training on Malondialdehyde and Protein Carbonyl Concentration in the Heart Tissue of Rats Exposed to Stanozolol |
| title_short | The Effect of Resistance Training on Malondialdehyde and Protein Carbonyl Concentration in the Heart Tissue of Rats Exposed to Stanozolol |
| title_sort | effect of resistance training on malondialdehyde and protein carbonyl concentration in the heart tissue of rats exposed to stanozolol |
| topic | malondialdehyde protein carbonyl resistance training stanazolol heart |
| url | http://pbr.mazums.ac.ir/article-1-321-en.html |
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