Psychological Stress and Functional Endometrial Disorders: Update of Mechanism Insights
The human endometrium plays a vital role in providing the site for embryo implantation and maintaining the normal development and survival of the embryo. Recent studies have shown that stress is a common factor for the development of unexplained reproductive disorders. The nonreceptive endometrium a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.690255/full |
| _version_ | 1831726248220426240 |
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| author | Jin-xiang Wu Shu Lin Shu Lin Shuang-bo Kong Shuang-bo Kong |
| author_facet | Jin-xiang Wu Shu Lin Shu Lin Shuang-bo Kong Shuang-bo Kong |
| author_sort | Jin-xiang Wu |
| collection | DOAJ |
| description | The human endometrium plays a vital role in providing the site for embryo implantation and maintaining the normal development and survival of the embryo. Recent studies have shown that stress is a common factor for the development of unexplained reproductive disorders. The nonreceptive endometrium and disturbed early maternal-fetal interaction might lead to infertility including the repeated embryo implantation failure and recurrent spontaneous abortion, or late pregnancy complications, thereby affecting the quality of life as well as the psychological status of the affected individuals. Additionally, psychological stress might also adversely affect female reproductive health. In recent years, several basic and clinical studies have tried to investigate the harm caused by psychological stress to reproductive health, however, the mechanism is still unclear. Here, we review the relationship between psychological stress and endometrial dysfunction, and its consequent effects on female infertility to provide new insights for clinical therapeutic interventions in the future. |
| first_indexed | 2024-12-21T06:05:22Z |
| format | Article |
| id | doaj.art-03bfa101ba084def931058af8825971b |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-21T06:05:22Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-03bfa101ba084def931058af8825971b2022-12-21T19:13:39ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-08-011210.3389/fendo.2021.690255690255Psychological Stress and Functional Endometrial Disorders: Update of Mechanism InsightsJin-xiang Wu0Shu Lin1Shu Lin2Shuang-bo Kong3Shuang-bo Kong4Department of Reproductive Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaCentre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDiabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW, AustraliaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, ChinaThe human endometrium plays a vital role in providing the site for embryo implantation and maintaining the normal development and survival of the embryo. Recent studies have shown that stress is a common factor for the development of unexplained reproductive disorders. The nonreceptive endometrium and disturbed early maternal-fetal interaction might lead to infertility including the repeated embryo implantation failure and recurrent spontaneous abortion, or late pregnancy complications, thereby affecting the quality of life as well as the psychological status of the affected individuals. Additionally, psychological stress might also adversely affect female reproductive health. In recent years, several basic and clinical studies have tried to investigate the harm caused by psychological stress to reproductive health, however, the mechanism is still unclear. Here, we review the relationship between psychological stress and endometrial dysfunction, and its consequent effects on female infertility to provide new insights for clinical therapeutic interventions in the future.https://www.frontiersin.org/articles/10.3389/fendo.2021.690255/fullpsychological stressendometrial receptivityrecurrent implantation failurehuman endometriuminfertility |
| spellingShingle | Jin-xiang Wu Shu Lin Shu Lin Shuang-bo Kong Shuang-bo Kong Psychological Stress and Functional Endometrial Disorders: Update of Mechanism Insights Frontiers in Endocrinology psychological stress endometrial receptivity recurrent implantation failure human endometrium infertility |
| title | Psychological Stress and Functional Endometrial Disorders: Update of Mechanism Insights |
| title_full | Psychological Stress and Functional Endometrial Disorders: Update of Mechanism Insights |
| title_fullStr | Psychological Stress and Functional Endometrial Disorders: Update of Mechanism Insights |
| title_full_unstemmed | Psychological Stress and Functional Endometrial Disorders: Update of Mechanism Insights |
| title_short | Psychological Stress and Functional Endometrial Disorders: Update of Mechanism Insights |
| title_sort | psychological stress and functional endometrial disorders update of mechanism insights |
| topic | psychological stress endometrial receptivity recurrent implantation failure human endometrium infertility |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.690255/full |
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