Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration
In the last decade, additive manufacturing (AM) processes have updated the fields of biomaterials science and drug delivery as they promise to realize bioengineered multifunctional devices and implantable tissue engineering (TE) scaffolds virtually designed by using computer-aided design (CAD) model...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.682133/full |
| _version_ | 1818835931533148160 |
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| author | Aurelio Salerno Paolo A. Netti Paolo A. Netti Paolo A. Netti |
| author_facet | Aurelio Salerno Paolo A. Netti Paolo A. Netti Paolo A. Netti |
| author_sort | Aurelio Salerno |
| collection | DOAJ |
| description | In the last decade, additive manufacturing (AM) processes have updated the fields of biomaterials science and drug delivery as they promise to realize bioengineered multifunctional devices and implantable tissue engineering (TE) scaffolds virtually designed by using computer-aided design (CAD) models. However, the current technological gap between virtual scaffold design and practical AM processes makes it still challenging to realize scaffolds capable of encoding all structural and cell regulatory functions of the native extracellular matrix (ECM) of health and diseased tissues. Indeed, engineering porous scaffolds capable of sequestering and presenting even a complex array of biochemical and biophysical signals in a time- and space-regulated manner, require advanced automated platforms suitable of processing simultaneously biomaterials, cells, and biomolecules at nanometric-size scale. The aim of this work was to review the recent scientific literature about AM fabrication of drug delivery scaffolds for TE. This review focused on bioactive molecule loading into three-dimensional (3D) porous scaffolds, and their release effects on cell fate and tissue growth. We reviewed CAD-based strategies, such as bioprinting, to achieve passive and stimuli-responsive drug delivery scaffolds for TE and cancer precision medicine. Finally, we describe the authors’ perspective regarding the next generation of CAD techniques and the advantages of AM, microfluidic, and soft lithography integration for enhancing 3D porous scaffold bioactivation toward functional bioengineered tissues and organs. |
| first_indexed | 2024-12-19T02:58:33Z |
| format | Article |
| id | doaj.art-03bfca2253fb4037b3f66f19450e9f75 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-19T02:58:33Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-03bfca2253fb4037b3f66f19450e9f752022-12-21T20:38:16ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-06-01910.3389/fbioe.2021.682133682133Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue RegenerationAurelio Salerno0Paolo A. Netti1Paolo A. Netti2Paolo A. Netti3Independent Researcher, Barcelona, SpainCenter for Advanced Biomaterials for Healthcare, Istituto Italiano di Tecnologia, Naples, ItalyDepartment of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II, Naples, ItalyInterdisciplinary Research Center on Biomaterials, University of Naples Federico II, Naples, ItalyIn the last decade, additive manufacturing (AM) processes have updated the fields of biomaterials science and drug delivery as they promise to realize bioengineered multifunctional devices and implantable tissue engineering (TE) scaffolds virtually designed by using computer-aided design (CAD) models. However, the current technological gap between virtual scaffold design and practical AM processes makes it still challenging to realize scaffolds capable of encoding all structural and cell regulatory functions of the native extracellular matrix (ECM) of health and diseased tissues. Indeed, engineering porous scaffolds capable of sequestering and presenting even a complex array of biochemical and biophysical signals in a time- and space-regulated manner, require advanced automated platforms suitable of processing simultaneously biomaterials, cells, and biomolecules at nanometric-size scale. The aim of this work was to review the recent scientific literature about AM fabrication of drug delivery scaffolds for TE. This review focused on bioactive molecule loading into three-dimensional (3D) porous scaffolds, and their release effects on cell fate and tissue growth. We reviewed CAD-based strategies, such as bioprinting, to achieve passive and stimuli-responsive drug delivery scaffolds for TE and cancer precision medicine. Finally, we describe the authors’ perspective regarding the next generation of CAD techniques and the advantages of AM, microfluidic, and soft lithography integration for enhancing 3D porous scaffold bioactivation toward functional bioengineered tissues and organs.https://www.frontiersin.org/articles/10.3389/fbioe.2021.682133/fulladditive manufacturingbiomimetic scaffoldscomputer-aided design (CAD) processesdrug deliverygrowth factor |
| spellingShingle | Aurelio Salerno Paolo A. Netti Paolo A. Netti Paolo A. Netti Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration Frontiers in Bioengineering and Biotechnology additive manufacturing biomimetic scaffolds computer-aided design (CAD) processes drug delivery growth factor |
| title | Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration |
| title_full | Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration |
| title_fullStr | Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration |
| title_full_unstemmed | Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration |
| title_short | Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration |
| title_sort | review on computer aided design and manufacturing of drug delivery scaffolds for cell guidance and tissue regeneration |
| topic | additive manufacturing biomimetic scaffolds computer-aided design (CAD) processes drug delivery growth factor |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2021.682133/full |
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