Guar gum/borax hydrogel: Rheological, low field NMR and release characterizations
Guar gum (GG) and Guar gum/borax (GGb) hydrogels are studied by means of rheology, Low Field Nuclear Magnetic Resonance (LF NMR) and model drug release tests. These three approaches are used to estimate the mesh size (ζ) of the polymeric network. A comparison with similar Scleroglucan syste...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Budapest University of Technology
2013-09-01
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| Series: | eXPRESS Polymer Letters |
| Subjects: | |
| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0004445&mi=cd |
| _version_ | 1819026670612381696 |
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| author | M. Grassi T. Coviello P. Matricardi F. Alhaique R. Farra G. Tesei S. Fiorentino F. Asaro G. Milcovich |
| author_facet | M. Grassi T. Coviello P. Matricardi F. Alhaique R. Farra G. Tesei S. Fiorentino F. Asaro G. Milcovich |
| author_sort | M. Grassi |
| collection | DOAJ |
| description | Guar gum (GG) and Guar gum/borax (GGb) hydrogels are studied by means of rheology, Low Field Nuclear Magnetic Resonance (LF NMR) and model drug release tests. These three approaches are used to estimate the mesh size (ζ) of the polymeric network. A comparison with similar Scleroglucan systems is carried out. In the case of GGb, the rheological and Low Field NMR estimations of ζ lead to comparable results, while the drug release approach seems to underestimate ζ. Such discrepancy is attributed to the viscous effect of some polymeric chains that, although bound to the network to one end, can freely fluctuate among meshes. The viscous drag exerted by these chains slows down drug diffusion through the polymeric network. A proof for this hypothesis is given by the case of Scleroglucan gel, where the viscous contribution is not so significant and a good agreement between the rheological and release test approaches was found. |
| first_indexed | 2024-12-21T05:30:16Z |
| format | Article |
| id | doaj.art-03c42b3ce61948809196f6f39ef08e31 |
| institution | Directory Open Access Journal |
| issn | 1788-618X |
| language | English |
| last_indexed | 2024-12-21T05:30:16Z |
| publishDate | 2013-09-01 |
| publisher | Budapest University of Technology |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj.art-03c42b3ce61948809196f6f39ef08e312022-12-21T19:14:33ZengBudapest University of TechnologyeXPRESS Polymer Letters1788-618X2013-09-017973374610.3144/expresspolymlett.2013.71Guar gum/borax hydrogel: Rheological, low field NMR and release characterizationsM. GrassiT. CovielloP. MatricardiF. AlhaiqueR. FarraG. TeseiS. FiorentinoF. AsaroG. MilcovichGuar gum (GG) and Guar gum/borax (GGb) hydrogels are studied by means of rheology, Low Field Nuclear Magnetic Resonance (LF NMR) and model drug release tests. These three approaches are used to estimate the mesh size (ζ) of the polymeric network. A comparison with similar Scleroglucan systems is carried out. In the case of GGb, the rheological and Low Field NMR estimations of ζ lead to comparable results, while the drug release approach seems to underestimate ζ. Such discrepancy is attributed to the viscous effect of some polymeric chains that, although bound to the network to one end, can freely fluctuate among meshes. The viscous drag exerted by these chains slows down drug diffusion through the polymeric network. A proof for this hypothesis is given by the case of Scleroglucan gel, where the viscous contribution is not so significant and a good agreement between the rheological and release test approaches was found.http://www.expresspolymlett.com/letolt.php?file=EPL-0004445&mi=cdPolymer gelsRheologyLow field NMRTransport processesMesh-size |
| spellingShingle | M. Grassi T. Coviello P. Matricardi F. Alhaique R. Farra G. Tesei S. Fiorentino F. Asaro G. Milcovich Guar gum/borax hydrogel: Rheological, low field NMR and release characterizations eXPRESS Polymer Letters Polymer gels Rheology Low field NMR Transport processes Mesh-size |
| title | Guar gum/borax hydrogel: Rheological, low field NMR and release characterizations |
| title_full | Guar gum/borax hydrogel: Rheological, low field NMR and release characterizations |
| title_fullStr | Guar gum/borax hydrogel: Rheological, low field NMR and release characterizations |
| title_full_unstemmed | Guar gum/borax hydrogel: Rheological, low field NMR and release characterizations |
| title_short | Guar gum/borax hydrogel: Rheological, low field NMR and release characterizations |
| title_sort | guar gum borax hydrogel rheological low field nmr and release characterizations |
| topic | Polymer gels Rheology Low field NMR Transport processes Mesh-size |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0004445&mi=cd |
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