Association of thiamine administration and prognosis in critically ill patients with heart failure
Background: Thiamine deficiency is common in patients with heart failure, and thiamine supplement can benefit these patients. However, the association between thiamine administration and prognosis among critically ill patients with heart failure remains unclear. Thus, this study aims to prove the su...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1162797/full |
| _version_ | 1797862079551504384 |
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| author | Rui Yang Jiasheng Huang Jiasheng Huang Yumei Zhao Yumei Zhao Jia Wang Dongdong Niu Enlin Ye Suru Yue Suru Yue Xuefei Hou Xuefei Hou Lili Cui Jiayuan Wu Jiayuan Wu |
| author_facet | Rui Yang Jiasheng Huang Jiasheng Huang Yumei Zhao Yumei Zhao Jia Wang Dongdong Niu Enlin Ye Suru Yue Suru Yue Xuefei Hou Xuefei Hou Lili Cui Jiayuan Wu Jiayuan Wu |
| author_sort | Rui Yang |
| collection | DOAJ |
| description | Background: Thiamine deficiency is common in patients with heart failure, and thiamine supplement can benefit these patients. However, the association between thiamine administration and prognosis among critically ill patients with heart failure remains unclear. Thus, this study aims to prove the survival benefit of thiamine use in critically ill patients with heart failure.Methods: A retrospective cohort analysis was performed on the basis of the Medical Information Mart of Intensive Care-Ⅳ database. Critically ill patients with heart failure were divided into the thiamine and non-thiamine groups depending on whether they had received thiamine therapy or not during hospitalization. The association between thiamine supplement and in-hospital mortality was assessed by using the Kaplan−Meier (KM) method and Cox proportional hazard models. A 1:1 nearest propensity-score matching (PSM) and propensity score-based inverse probability of treatment weighting (IPW) were also performed to ensure the robustness of the findings.Results: A total of 7,021 patients were included in this study, with 685 and 6,336 in the thiamine and non-thiamine groups, respectively. The kaplan−meier survival curves indicated that the thiamine group had a lower in-hospital mortality than the none-thiamine group. After adjusting for various confounders, the Cox regression models showed significant beneficial effects of thiamine administration on in-hospital mortality among critically ill patients with heart failure with a hazard ratio of 0.78 (95% confidence interval: 0.67–0.89) in the fully adjusted model. propensity-score matching and probability of treatment weighting analyses also achieved consistent results.Conclusion: Thiamine supplement is associated with a decreased risk of in-hospital mortality in critically ill patients with heart failure who are admitted to the ICU. Further multicenter and well-designed randomized controlled trials with large sample sizes are necessary to validate this finding. |
| first_indexed | 2024-04-09T22:13:29Z |
| format | Article |
| id | doaj.art-03c61e9917b441a6bdb0b1363a1ed3dd |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T22:13:29Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-03c61e9917b441a6bdb0b1363a1ed3dd2023-03-23T04:58:38ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-03-011410.3389/fphar.2023.11627971162797Association of thiamine administration and prognosis in critically ill patients with heart failureRui Yang0Jiasheng Huang1Jiasheng Huang2Yumei Zhao3Yumei Zhao4Jia Wang5Dongdong Niu6Enlin Ye7Suru Yue8Suru Yue9Xuefei Hou10Xuefei Hou11Lili Cui12Jiayuan Wu13Jiayuan Wu14Clinical Research Service Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaClinical Research Service Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Engineering Research Center of Collaborative Innovation Technology of Clinical Medical Big Data Cloud Service in Medical Consortium of West Guangdong Province, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaClinical Research Service Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Engineering Research Center of Collaborative Innovation Technology of Clinical Medical Big Data Cloud Service in Medical Consortium of West Guangdong Province, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaClinical Research Service Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaClinical Research Service Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaClinical Research Service Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaClinical Research Service Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Engineering Research Center of Collaborative Innovation Technology of Clinical Medical Big Data Cloud Service in Medical Consortium of West Guangdong Province, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaClinical Research Service Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Engineering Research Center of Collaborative Innovation Technology of Clinical Medical Big Data Cloud Service in Medical Consortium of West Guangdong Province, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaClinical Research Service Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Engineering Research Center of Collaborative Innovation Technology of Clinical Medical Big Data Cloud Service in Medical Consortium of West Guangdong Province, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaBackground: Thiamine deficiency is common in patients with heart failure, and thiamine supplement can benefit these patients. However, the association between thiamine administration and prognosis among critically ill patients with heart failure remains unclear. Thus, this study aims to prove the survival benefit of thiamine use in critically ill patients with heart failure.Methods: A retrospective cohort analysis was performed on the basis of the Medical Information Mart of Intensive Care-Ⅳ database. Critically ill patients with heart failure were divided into the thiamine and non-thiamine groups depending on whether they had received thiamine therapy or not during hospitalization. The association between thiamine supplement and in-hospital mortality was assessed by using the Kaplan−Meier (KM) method and Cox proportional hazard models. A 1:1 nearest propensity-score matching (PSM) and propensity score-based inverse probability of treatment weighting (IPW) were also performed to ensure the robustness of the findings.Results: A total of 7,021 patients were included in this study, with 685 and 6,336 in the thiamine and non-thiamine groups, respectively. The kaplan−meier survival curves indicated that the thiamine group had a lower in-hospital mortality than the none-thiamine group. After adjusting for various confounders, the Cox regression models showed significant beneficial effects of thiamine administration on in-hospital mortality among critically ill patients with heart failure with a hazard ratio of 0.78 (95% confidence interval: 0.67–0.89) in the fully adjusted model. propensity-score matching and probability of treatment weighting analyses also achieved consistent results.Conclusion: Thiamine supplement is associated with a decreased risk of in-hospital mortality in critically ill patients with heart failure who are admitted to the ICU. Further multicenter and well-designed randomized controlled trials with large sample sizes are necessary to validate this finding.https://www.frontiersin.org/articles/10.3389/fphar.2023.1162797/fullthiamineheart failurein-hospital mortalityintensive care unitMIMIC-Ⅳ database |
| spellingShingle | Rui Yang Jiasheng Huang Jiasheng Huang Yumei Zhao Yumei Zhao Jia Wang Dongdong Niu Enlin Ye Suru Yue Suru Yue Xuefei Hou Xuefei Hou Lili Cui Jiayuan Wu Jiayuan Wu Association of thiamine administration and prognosis in critically ill patients with heart failure Frontiers in Pharmacology thiamine heart failure in-hospital mortality intensive care unit MIMIC-Ⅳ database |
| title | Association of thiamine administration and prognosis in critically ill patients with heart failure |
| title_full | Association of thiamine administration and prognosis in critically ill patients with heart failure |
| title_fullStr | Association of thiamine administration and prognosis in critically ill patients with heart failure |
| title_full_unstemmed | Association of thiamine administration and prognosis in critically ill patients with heart failure |
| title_short | Association of thiamine administration and prognosis in critically ill patients with heart failure |
| title_sort | association of thiamine administration and prognosis in critically ill patients with heart failure |
| topic | thiamine heart failure in-hospital mortality intensive care unit MIMIC-Ⅳ database |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1162797/full |
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