Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis
Purpose: To quantitatively assess the angiographic features of uveitis associated with sarcoidosis on ultra-widefield fluorescein angiography (UWFA) and determine their correlations with clinical features. Design: A retrospective cohort study. Methods: Sixty-four eyes (64 patients) with sarcoidosis...
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Elsevier
2022-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022025063 |
| _version_ | 1797987972339990528 |
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| author | Hyun Suh Anna Lee Ho Ra Jun Hyuck Lee Jiwon Baek |
| author_facet | Hyun Suh Anna Lee Ho Ra Jun Hyuck Lee Jiwon Baek |
| author_sort | Hyun Suh |
| collection | DOAJ |
| description | Purpose: To quantitatively assess the angiographic features of uveitis associated with sarcoidosis on ultra-widefield fluorescein angiography (UWFA) and determine their correlations with clinical features. Design: A retrospective cohort study. Methods: Sixty-four eyes (64 patients) with sarcoidosis uveitis were included. On UWFA, presence of vasculitis, macular leakage, and optic disc leakage were assessed and features including peripheral ischemic area, vascular leakage area, and punched out lesions were quantitatively analyzed using FIJI (ImageJ2) and correlated with clinical features. Results: The mean peripheral ischemic area and leakage area were 0.0419 ± 0.113% and 0.0333 ± 0.0287% of the total retinal area, respectively. Macular and optic disc leakage were present in 18.8% and 59.4% of eyes, respectively. The average number of punched out lesions was 10.02 ± 21.95. Those changes were most abundant in the inferotemporal area. The presence of disc leakage correlated with all the other UWFA parameters (all r ≥ 0.260; all P ≤ 0.038). The leakage area correlated with vitreous cells, baseline and 6-month logMAR visual acuity, steroid dose and duration, erythrocyte sedimentation rate, and C-reactive protein (r = 0.472, 0.288, 0.321, 0.374, 0.250, 0.251, and 0.277; all P ≤ 0.46). Conclusions: This study quantitatively analyzed UWFA data in sarcoidosis uveitis. Angiographic changes were most frequent in the inferotemporal area. UWFA parameters correlated with one another and clinical variables. These quantitative imaging results warrant a subjective analysis of sarcoidosis uveitis. |
| first_indexed | 2024-04-11T07:56:35Z |
| format | Article |
| id | doaj.art-03c633d818ac40fd882269f8a61a04e1 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-11T07:56:35Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-03c633d818ac40fd882269f8a61a04e12022-12-22T04:35:55ZengElsevierHeliyon2405-84402022-11-01811e11218Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosisHyun Suh0Anna Lee1Ho Ra2Jun Hyuck Lee3Jiwon Baek4Department of Ophthalmology, Bucheon St. Mary's Hospital, College of Medicine, Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaDepartment of Ophthalmology, Asan Medical Center, Seoul, Republic of KoreaDepartment of Ophthalmology, Bucheon St. Mary's Hospital, College of Medicine, Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaDepartment of Ophthalmology, Bucheon St. Mary's Hospital, College of Medicine, Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of KoreaDepartment of Ophthalmology, Bucheon St. Mary's Hospital, College of Medicine, Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea; Department of Ophthalmology, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea; Corresponding author.Purpose: To quantitatively assess the angiographic features of uveitis associated with sarcoidosis on ultra-widefield fluorescein angiography (UWFA) and determine their correlations with clinical features. Design: A retrospective cohort study. Methods: Sixty-four eyes (64 patients) with sarcoidosis uveitis were included. On UWFA, presence of vasculitis, macular leakage, and optic disc leakage were assessed and features including peripheral ischemic area, vascular leakage area, and punched out lesions were quantitatively analyzed using FIJI (ImageJ2) and correlated with clinical features. Results: The mean peripheral ischemic area and leakage area were 0.0419 ± 0.113% and 0.0333 ± 0.0287% of the total retinal area, respectively. Macular and optic disc leakage were present in 18.8% and 59.4% of eyes, respectively. The average number of punched out lesions was 10.02 ± 21.95. Those changes were most abundant in the inferotemporal area. The presence of disc leakage correlated with all the other UWFA parameters (all r ≥ 0.260; all P ≤ 0.038). The leakage area correlated with vitreous cells, baseline and 6-month logMAR visual acuity, steroid dose and duration, erythrocyte sedimentation rate, and C-reactive protein (r = 0.472, 0.288, 0.321, 0.374, 0.250, 0.251, and 0.277; all P ≤ 0.46). Conclusions: This study quantitatively analyzed UWFA data in sarcoidosis uveitis. Angiographic changes were most frequent in the inferotemporal area. UWFA parameters correlated with one another and clinical variables. These quantitative imaging results warrant a subjective analysis of sarcoidosis uveitis.http://www.sciencedirect.com/science/article/pii/S2405844022025063Angiographic analysisQuantitativeUltra-widefield fluorescein angiographyUveitisOcular sarcoidosis |
| spellingShingle | Hyun Suh Anna Lee Ho Ra Jun Hyuck Lee Jiwon Baek Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis Heliyon Angiographic analysis Quantitative Ultra-widefield fluorescein angiography Uveitis Ocular sarcoidosis |
| title | Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis |
| title_full | Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis |
| title_fullStr | Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis |
| title_full_unstemmed | Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis |
| title_short | Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis |
| title_sort | quantitative analysis of ultra widefield fluorescein angiography in uveitis associated with sarcoidosis |
| topic | Angiographic analysis Quantitative Ultra-widefield fluorescein angiography Uveitis Ocular sarcoidosis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022025063 |
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