IL-34 Downregulation‒Associated M1/M2 Macrophage Imbalance Is Related to Inflammaging in Sun-Exposed Human Skin

IL-34 Downregulation‒Associated M1/M2 Macrophage Imbalance Is Related to Inflammaging in Sun-Exposed Human Skin

Macrophages can be polarized into two subsets: a proinflammatory (M1) or an anti-inflammatory (M2) phenotype. In this study, we show that an increased M1-to-M2 ratio associated with a decrease in IL-34 induces skin inflammaging. The total number of macrophages in the dermis did not change, but the n...

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Bibliographic Details
Main Authors: Satoshi Horiba, Ryota Kami, Taiki Tsutsui, Junichi Hosoi
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:JID Innovations
Online Access:http://www.sciencedirect.com/science/article/pii/S2667026722000194

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