Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation
Chronic inflammation is associated with various chronic diseases, including cardiovascular disease, neurodegenerative disease, and cancer, which severely affect the health and quality of life of people. Oxidative stress induced by unbalanced production and elimination of reactive oxygen species (ROS...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.974794/full |
| _version_ | 1828084555655938048 |
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| author | Yidan Xia Dongxu Wang Jiaqi Li Minqi Chen Duo Wang Ziping Jiang Bin Liu |
| author_facet | Yidan Xia Dongxu Wang Jiaqi Li Minqi Chen Duo Wang Ziping Jiang Bin Liu |
| author_sort | Yidan Xia |
| collection | DOAJ |
| description | Chronic inflammation is associated with various chronic diseases, including cardiovascular disease, neurodegenerative disease, and cancer, which severely affect the health and quality of life of people. Oxidative stress induced by unbalanced production and elimination of reactive oxygen species (ROS) is one of the essential risk factors for chronic inflammation. Recent studies, including the studies of mushrooms, which have received considerable attention, report that the antioxidant effects of natural compounds have more advantages than synthetic antioxidants. Mushrooms have been consumed by humans as precious nourishment for 3,000 years, and so far, more than 350 types have been identified in China. Mushrooms are rich in polysaccharides, peptides, polyphenols, alkaloids, and terpenoids and are associated with several healthy biological functions, especially antioxidant properties. As such, the extracts purified from mushrooms could activate the expression of antioxidant enzymes through the Keap1/Nrf2/ARE pathway to neutralize excessive ROS and inhibit ROS-induced chronic inflammation through the NF-κB pathway. Recently, the antioxidant properties of mushrooms have been successfully applied to treating cardiovascular disease (CAD), neurodegenerative diseases, diabetes mellitus, and cancer. The present review summarizes the antioxidant properties and the mechanism of compounds purified from mushrooms, emphasizing the oxidative stress regulation of mushrooms to fight against chronic inflammation. |
| first_indexed | 2024-04-11T04:27:46Z |
| format | Article |
| id | doaj.art-03c6dc16d1064263af24b658b81db4b1 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T04:27:46Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-03c6dc16d1064263af24b658b81db4b12022-12-29T14:37:14ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.974794974794Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulationYidan Xia0Dongxu Wang1Jiaqi Li2Minqi Chen3Duo Wang4Ziping Jiang5Bin Liu6Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, ChinaLaboratory Animal Center, College of Animal Science, Jilin University, Changchun, ChinaDepartment of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, ChinaDepartment of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, ChinaDepartment of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, ChinaDepartment of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, ChinaDepartment of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, ChinaChronic inflammation is associated with various chronic diseases, including cardiovascular disease, neurodegenerative disease, and cancer, which severely affect the health and quality of life of people. Oxidative stress induced by unbalanced production and elimination of reactive oxygen species (ROS) is one of the essential risk factors for chronic inflammation. Recent studies, including the studies of mushrooms, which have received considerable attention, report that the antioxidant effects of natural compounds have more advantages than synthetic antioxidants. Mushrooms have been consumed by humans as precious nourishment for 3,000 years, and so far, more than 350 types have been identified in China. Mushrooms are rich in polysaccharides, peptides, polyphenols, alkaloids, and terpenoids and are associated with several healthy biological functions, especially antioxidant properties. As such, the extracts purified from mushrooms could activate the expression of antioxidant enzymes through the Keap1/Nrf2/ARE pathway to neutralize excessive ROS and inhibit ROS-induced chronic inflammation through the NF-κB pathway. Recently, the antioxidant properties of mushrooms have been successfully applied to treating cardiovascular disease (CAD), neurodegenerative diseases, diabetes mellitus, and cancer. The present review summarizes the antioxidant properties and the mechanism of compounds purified from mushrooms, emphasizing the oxidative stress regulation of mushrooms to fight against chronic inflammation.https://www.frontiersin.org/articles/10.3389/fphar.2022.974794/fullchronic diseasesnatural compoundsedible fungiantioxidantsmolecular mechanisms |
| spellingShingle | Yidan Xia Dongxu Wang Jiaqi Li Minqi Chen Duo Wang Ziping Jiang Bin Liu Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation Frontiers in Pharmacology chronic diseases natural compounds edible fungi antioxidants molecular mechanisms |
| title | Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation |
| title_full | Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation |
| title_fullStr | Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation |
| title_full_unstemmed | Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation |
| title_short | Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation |
| title_sort | compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation |
| topic | chronic diseases natural compounds edible fungi antioxidants molecular mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.974794/full |
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