Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
Graphical AbstractAMD, age-related macular degeneration; PCV, polypoidal choroidal vasculopathy; PLS-DA, partial least squares discriminant analysis; LPC, lysophosphatidylcholine; PC, phosphocholine; ROC, operating characteristic curve; AUC, area under the receiver operating characteristic curve; vW...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.991879/full |
| _version_ | 1811266684646850560 |
|---|---|
| author | Yinchen Shen Yinchen Shen Yinchen Shen Yinchen Shen Yinchen Shen Hanying Wang Hanying Wang Hanying Wang Hanying Wang Hanying Wang Xiaoyin Xu Xiaoyin Xu Xiaoyin Xu Xiaoyin Xu Xiaoyin Xu Chong Chen Chong Chen Chong Chen Chong Chen Chong Chen Shaopin Zhu Shaopin Zhu Shaopin Zhu Shaopin Zhu Shaopin Zhu Lu Cheng Lu Cheng Lu Cheng Lu Cheng Lu Cheng Junwei Fang Junwei Fang Junwei Fang Junwei Fang Junwei Fang Kun Liu Kun Liu Kun Liu Kun Liu Kun Liu Xun Xu Xun Xu Xun Xu Xun Xu Xun Xu |
| author_facet | Yinchen Shen Yinchen Shen Yinchen Shen Yinchen Shen Yinchen Shen Hanying Wang Hanying Wang Hanying Wang Hanying Wang Hanying Wang Xiaoyin Xu Xiaoyin Xu Xiaoyin Xu Xiaoyin Xu Xiaoyin Xu Chong Chen Chong Chen Chong Chen Chong Chen Chong Chen Shaopin Zhu Shaopin Zhu Shaopin Zhu Shaopin Zhu Shaopin Zhu Lu Cheng Lu Cheng Lu Cheng Lu Cheng Lu Cheng Junwei Fang Junwei Fang Junwei Fang Junwei Fang Junwei Fang Kun Liu Kun Liu Kun Liu Kun Liu Kun Liu Xun Xu Xun Xu Xun Xu Xun Xu Xun Xu |
| author_sort | Yinchen Shen |
| collection | DOAJ |
| description | Graphical AbstractAMD, age-related macular degeneration; PCV, polypoidal choroidal vasculopathy; PLS-DA, partial least squares discriminant analysis; LPC, lysophosphatidylcholine; PC, phosphocholine; ROC, operating characteristic curve; AUC, area under the receiver operating characteristic curve; vWF, von Willebrand Factor. Note: The protein structure of vWF is downloaded from PDB (https://www.rcsb.org/). |
| first_indexed | 2024-04-12T20:47:43Z |
| format | Article |
| id | doaj.art-03c7b4d023084868b0b5b2c432dd5834 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T20:47:43Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-03c7b4d023084868b0b5b2c432dd58342022-12-22T03:17:12ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.991879991879Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathyYinchen Shen0Yinchen Shen1Yinchen Shen2Yinchen Shen3Yinchen Shen4Hanying Wang5Hanying Wang6Hanying Wang7Hanying Wang8Hanying Wang9Xiaoyin Xu10Xiaoyin Xu11Xiaoyin Xu12Xiaoyin Xu13Xiaoyin Xu14Chong Chen15Chong Chen16Chong Chen17Chong Chen18Chong Chen19Shaopin Zhu20Shaopin Zhu21Shaopin Zhu22Shaopin Zhu23Shaopin Zhu24Lu Cheng25Lu Cheng26Lu Cheng27Lu Cheng28Lu Cheng29Junwei Fang30Junwei Fang31Junwei Fang32Junwei Fang33Junwei Fang34Kun Liu35Kun Liu36Kun Liu37Kun Liu38Kun Liu39Xun Xu40Xun Xu41Xun Xu42Xun Xu43Xun Xu44Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaNational Clinical Research Center for Eye Diseases, Shanghai, ChinaShanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, ChinaShanghai Engineering Center for Visual Science and Photomedicine, Shanghai, ChinaShanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaNational Clinical Research Center for Eye Diseases, Shanghai, ChinaShanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, ChinaShanghai Engineering Center for Visual Science and Photomedicine, Shanghai, ChinaShanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaNational Clinical Research Center for Eye Diseases, Shanghai, ChinaShanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, ChinaShanghai Engineering Center for Visual Science and Photomedicine, Shanghai, ChinaShanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaNational Clinical Research Center for Eye Diseases, Shanghai, ChinaShanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, ChinaShanghai Engineering Center for Visual Science and Photomedicine, Shanghai, ChinaShanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaNational Clinical Research Center for Eye Diseases, Shanghai, ChinaShanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, ChinaShanghai Engineering Center for Visual Science and Photomedicine, Shanghai, ChinaShanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaNational Clinical Research Center for Eye Diseases, Shanghai, ChinaShanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, ChinaShanghai Engineering Center for Visual Science and Photomedicine, Shanghai, ChinaShanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaNational Clinical Research Center for Eye Diseases, Shanghai, ChinaShanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, ChinaShanghai Engineering Center for Visual Science and Photomedicine, Shanghai, ChinaShanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaNational Clinical Research Center for Eye Diseases, Shanghai, ChinaShanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, ChinaShanghai Engineering Center for Visual Science and Photomedicine, Shanghai, ChinaShanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaNational Clinical Research Center for Eye Diseases, Shanghai, ChinaShanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, ChinaShanghai Engineering Center for Visual Science and Photomedicine, Shanghai, ChinaShanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaGraphical AbstractAMD, age-related macular degeneration; PCV, polypoidal choroidal vasculopathy; PLS-DA, partial least squares discriminant analysis; LPC, lysophosphatidylcholine; PC, phosphocholine; ROC, operating characteristic curve; AUC, area under the receiver operating characteristic curve; vWF, von Willebrand Factor. Note: The protein structure of vWF is downloaded from PDB (https://www.rcsb.org/).https://www.frontiersin.org/articles/10.3389/fphar.2022.991879/fullanti-vegfneovascular age-related macular degenerationpolypoidal choroidal vasculopathymetabolomicstreatment response |
| spellingShingle | Yinchen Shen Yinchen Shen Yinchen Shen Yinchen Shen Yinchen Shen Hanying Wang Hanying Wang Hanying Wang Hanying Wang Hanying Wang Xiaoyin Xu Xiaoyin Xu Xiaoyin Xu Xiaoyin Xu Xiaoyin Xu Chong Chen Chong Chen Chong Chen Chong Chen Chong Chen Shaopin Zhu Shaopin Zhu Shaopin Zhu Shaopin Zhu Shaopin Zhu Lu Cheng Lu Cheng Lu Cheng Lu Cheng Lu Cheng Junwei Fang Junwei Fang Junwei Fang Junwei Fang Junwei Fang Kun Liu Kun Liu Kun Liu Kun Liu Kun Liu Xun Xu Xun Xu Xun Xu Xun Xu Xun Xu Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy Frontiers in Pharmacology anti-vegf neovascular age-related macular degeneration polypoidal choroidal vasculopathy metabolomics treatment response |
| title | Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy |
| title_full | Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy |
| title_fullStr | Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy |
| title_full_unstemmed | Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy |
| title_short | Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy |
| title_sort | metabolomics study of treatment response to conbercept of patients with neovascular age related macular degeneration and polypoidal choroidal vasculopathy |
| topic | anti-vegf neovascular age-related macular degeneration polypoidal choroidal vasculopathy metabolomics treatment response |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.991879/full |
| work_keys_str_mv | AT yinchenshen metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT yinchenshen metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT yinchenshen metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT yinchenshen metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT yinchenshen metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT hanyingwang metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT hanyingwang metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT hanyingwang metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT hanyingwang metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT hanyingwang metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT xiaoyinxu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT xiaoyinxu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT xiaoyinxu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT xiaoyinxu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT xiaoyinxu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT chongchen metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT chongchen metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT chongchen metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT chongchen metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT chongchen metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT shaopinzhu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT shaopinzhu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT shaopinzhu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT shaopinzhu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT shaopinzhu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT lucheng metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT lucheng metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT lucheng metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT lucheng metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT lucheng metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT junweifang metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT junweifang metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT junweifang metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT junweifang metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT junweifang metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT kunliu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT kunliu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT kunliu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT kunliu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT kunliu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT xunxu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT xunxu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT xunxu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT xunxu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy AT xunxu metabolomicsstudyoftreatmentresponsetoconberceptofpatientswithneovascularagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathy |