Co-Targeting the EGFR and PI3K/Akt Pathway to Overcome Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma: What about Autophagy?

Co-Targeting the EGFR and PI3K/Akt Pathway to Overcome Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma: What about Autophagy?

Resistance to EGFR-targeted therapy is a major obstacle on the road to effective treatment options for head and neck cancers. During the search for underlying mechanisms and regulators of this resistance, there were several indications that EGFR-targeted therapy resistance is (partially) mediated by...

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Bibliographic Details
Main Authors: Hannah Zaryouh, Jinthe Van Loenhout, Marc Peeters, Jan Baptist Vermorken, Filip Lardon, An Wouters
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
HNSCC
EGFR
PI3K/Akt
cetuximab
resistance
autophagy
Online Access:https://www.mdpi.com/2072-6694/14/24/6128

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