Ultrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis
Abstract Background This study investigated the relationship between liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis. We used an acoustic radiation force impulse (ARFI) technique to measure stiffness, and a radio frequency (RF) vascular quantitative ultrasound...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | BMC Gastroenterology |
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| Online Access: | http://link.springer.com/article/10.1186/s12876-018-0910-z |
| _version_ | 1818334825186066432 |
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| author | Jing-Hua Li Ning Zhu Ying-Bin Min Xiang-Zhou Shi Yun-You Duan Yi-Lin Yang |
| author_facet | Jing-Hua Li Ning Zhu Ying-Bin Min Xiang-Zhou Shi Yun-You Duan Yi-Lin Yang |
| author_sort | Jing-Hua Li |
| collection | DOAJ |
| description | Abstract Background This study investigated the relationship between liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis. We used an acoustic radiation force impulse (ARFI) technique to measure stiffness, and a radio frequency (RF) vascular quantitative ultrasound technique to measure changes in common carotid artery elasticity and vascular function. Methods Two-hundred seventeen patients with chronic viral hepatitis caused by either hepatitis B virus (HBV) or hepatitis C virus (HCV) were enrolled. We divided the patients into two groups, one comprising 147 patients with chronic hepatitis B (CHB) (98 men and 49 women, average age 46.5 ± 12.2 years) and another comprising 70 patients with chronic hepatitis C (CHC) (47 men and 23 women, average age 47.6 ± 12.1 years). Additionally, 64 healthy age- and sex-matched participants (43 men and 21 women, average age 47.8 ± 5.1 years) were selected as the control group. The ARFI technique was used to measure liver stiffness and the RF ultrasound technique was used to measure carotid artery elasticity parameters including intima-media thickness (IMT), pulse wave velocity (PWV), arterial wall dilation coefficient (DC), compliance coefficient (CC), sclerosis indices α and β, and augmentation index (Aix). Clinical indicators, liver stiffness, and carotid artery elasticity parameters were observed and compared between the different age groups to investigate the correlation between carotid artery elasticity parameters and liver stiffness. Results The ARFI values for the CHB and CHC groups were significantly higher than those for the control group (1.84 ± 0.52 vs. 1.04 ± 0.11 m/s; 1.86 ± 0.37 vs. 1.04 ± 0.11 m/s, respectively; P < 0.001). When compared to the control group, both CHB and CHC groups showed an IMT of the same order, but had significantly higher elasticity parameters, such as α and β, as well as lower DC and CC values (P < 0.001). The PWV of the CHC group was significantly higher than that of the control group (7.98 ± 1.42 vs. 6.09 ± 0.90 m/s, P < 0.001). In the CHB group, all parameters including ARFI, IMT, PWV, DC, CC, α and β, were significantly different between the two age groups (P < 0.05). Within the CHC group, all parameters including IMT, PWV, DC, α and β, were significantly different between the two age groups (P < 0.05), except for ARFI, wherein the difference was not statistically significant. The correlation analysis and stepwise multiple linear regression analysis indicated that for patients with CHB, age was an independent predictor of common carotid artery IMT (R2 = 0.468, F = 54.635, and P < 0.001). For patients with CHC, age and blood sugar were independent predictors of common carotid artery IMT (R2 = 0.465, F = 29.118, and P < 0.001). Conclusion Although based on ARFI and RF ultrasound, the carotid artery IMT in patients with CHB and CHC was not significantly higher than that in the control group, their functional elasticity parameters had already changed. This finding serves as a useful reference for the clinical diagnosis of vascular diseases in patients with viral hepatitis. Trial registration ClinicalTrials: ChiCTR1800015859 25/04/2018. |
| first_indexed | 2024-12-13T14:13:41Z |
| format | Article |
| id | doaj.art-03cac121ca1b4906a226ff25e98ca144 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-13T14:13:41Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-03cac121ca1b4906a226ff25e98ca1442022-12-21T23:42:22ZengBMCBMC Gastroenterology1471-230X2018-12-011811810.1186/s12876-018-0910-zUltrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitisJing-Hua Li0Ning Zhu1Ying-Bin Min2Xiang-Zhou Shi3Yun-You Duan4Yi-Lin Yang5Department of Ultrasound Diagnosis, Tangdu Hospital, Fourth Military Medical UniversityDepartment of Ultrasound Diagnosis, Tangdu Hospital, Fourth Military Medical UniversityDepartment of Ultrasound Diagnosis, Tangdu Hospital, Fourth Military Medical UniversityDepartment of Ultrasound Diagnosis, Tangdu Hospital, Fourth Military Medical UniversityDepartment of Ultrasound Diagnosis, Tangdu Hospital, Fourth Military Medical UniversityDepartment of Ultrasound Diagnosis, Tangdu Hospital, Fourth Military Medical UniversityAbstract Background This study investigated the relationship between liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis. We used an acoustic radiation force impulse (ARFI) technique to measure stiffness, and a radio frequency (RF) vascular quantitative ultrasound technique to measure changes in common carotid artery elasticity and vascular function. Methods Two-hundred seventeen patients with chronic viral hepatitis caused by either hepatitis B virus (HBV) or hepatitis C virus (HCV) were enrolled. We divided the patients into two groups, one comprising 147 patients with chronic hepatitis B (CHB) (98 men and 49 women, average age 46.5 ± 12.2 years) and another comprising 70 patients with chronic hepatitis C (CHC) (47 men and 23 women, average age 47.6 ± 12.1 years). Additionally, 64 healthy age- and sex-matched participants (43 men and 21 women, average age 47.8 ± 5.1 years) were selected as the control group. The ARFI technique was used to measure liver stiffness and the RF ultrasound technique was used to measure carotid artery elasticity parameters including intima-media thickness (IMT), pulse wave velocity (PWV), arterial wall dilation coefficient (DC), compliance coefficient (CC), sclerosis indices α and β, and augmentation index (Aix). Clinical indicators, liver stiffness, and carotid artery elasticity parameters were observed and compared between the different age groups to investigate the correlation between carotid artery elasticity parameters and liver stiffness. Results The ARFI values for the CHB and CHC groups were significantly higher than those for the control group (1.84 ± 0.52 vs. 1.04 ± 0.11 m/s; 1.86 ± 0.37 vs. 1.04 ± 0.11 m/s, respectively; P < 0.001). When compared to the control group, both CHB and CHC groups showed an IMT of the same order, but had significantly higher elasticity parameters, such as α and β, as well as lower DC and CC values (P < 0.001). The PWV of the CHC group was significantly higher than that of the control group (7.98 ± 1.42 vs. 6.09 ± 0.90 m/s, P < 0.001). In the CHB group, all parameters including ARFI, IMT, PWV, DC, CC, α and β, were significantly different between the two age groups (P < 0.05). Within the CHC group, all parameters including IMT, PWV, DC, α and β, were significantly different between the two age groups (P < 0.05), except for ARFI, wherein the difference was not statistically significant. The correlation analysis and stepwise multiple linear regression analysis indicated that for patients with CHB, age was an independent predictor of common carotid artery IMT (R2 = 0.468, F = 54.635, and P < 0.001). For patients with CHC, age and blood sugar were independent predictors of common carotid artery IMT (R2 = 0.465, F = 29.118, and P < 0.001). Conclusion Although based on ARFI and RF ultrasound, the carotid artery IMT in patients with CHB and CHC was not significantly higher than that in the control group, their functional elasticity parameters had already changed. This finding serves as a useful reference for the clinical diagnosis of vascular diseases in patients with viral hepatitis. Trial registration ClinicalTrials: ChiCTR1800015859 25/04/2018.http://link.springer.com/article/10.1186/s12876-018-0910-zUltrasoundHBVHCVCarotid artery elasticity |
| spellingShingle | Jing-Hua Li Ning Zhu Ying-Bin Min Xiang-Zhou Shi Yun-You Duan Yi-Lin Yang Ultrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis BMC Gastroenterology Ultrasound HBV HCV Carotid artery elasticity |
| title | Ultrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis |
| title_full | Ultrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis |
| title_fullStr | Ultrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis |
| title_full_unstemmed | Ultrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis |
| title_short | Ultrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis |
| title_sort | ultrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis |
| topic | Ultrasound HBV HCV Carotid artery elasticity |
| url | http://link.springer.com/article/10.1186/s12876-018-0910-z |
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