Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity
(1) Background: There is a growing need for the development of new methods for the synthesis of nanoparticles. The interest in such particles has raised concerns about the environmental safety of their production methods; (2) Objectives: The current methods of nanoparticle production are often expen...
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| Format: | Article |
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MDPI AG
2018-03-01
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| Series: | Nanomaterials |
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| Online Access: | http://www.mdpi.com/2079-4991/8/3/174 |
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| author | Alaa A. A. Aljabali Yazan Akkam Mazhar Salim Al Zoubi Khalid M. Al-Batayneh Bahaa Al-Trad Osama Abo Alrob Alaaldin M. Alkilany Mourad Benamara David J. Evans |
| author_facet | Alaa A. A. Aljabali Yazan Akkam Mazhar Salim Al Zoubi Khalid M. Al-Batayneh Bahaa Al-Trad Osama Abo Alrob Alaaldin M. Alkilany Mourad Benamara David J. Evans |
| author_sort | Alaa A. A. Aljabali |
| collection | DOAJ |
| description | (1) Background: There is a growing need for the development of new methods for the synthesis of nanoparticles. The interest in such particles has raised concerns about the environmental safety of their production methods; (2) Objectives: The current methods of nanoparticle production are often expensive and employ chemicals that are potentially harmful to the environment, which calls for the development of “greener” protocols. Herein we describe the synthesis of gold nanoparticles (AuNPs) using plant extracts, which offers an alternative, efficient, inexpensive, and environmentally friendly method to produce well-defined geometries of nanoparticles; (3) Methods: The phytochemicals present in the aqueous leaf extract acted as an effective reducing agent. The generated AuNPs were characterized by Transmission electron microscopy (TEM), Scanning electron microscope (SEM), and Atomic Force microscopy (AFM), X-ray diffraction (XRD), UV-visible spectroscopy, energy dispersive X-ray (EDX), and thermogravimetric analyses (TGA); (4) Results and Conclusions: The prepared nanoparticles were found to be biocompatible and exhibited no antimicrobial or antifungal effect, deeming the particles safe for various applications in nanomedicine. TGA analysis revealed that biomolecules, which were present in the plant extract, capped the nanoparticles and acted as stabilizing agents. |
| first_indexed | 2024-04-13T18:31:02Z |
| format | Article |
| id | doaj.art-03cb69feffce461daab360313ec007b1 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-04-13T18:31:02Z |
| publishDate | 2018-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-03cb69feffce461daab360313ec007b12022-12-22T02:35:04ZengMDPI AGNanomaterials2079-49912018-03-018317410.3390/nano8030174nano8030174Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial ActivityAlaa A. A. Aljabali0Yazan Akkam1Mazhar Salim Al Zoubi2Khalid M. Al-Batayneh3Bahaa Al-Trad4Osama Abo Alrob5Alaaldin M. Alkilany6Mourad Benamara7David J. Evans8Faculty of Pharmacy, Yarmouk University, P.O.BOX 566, Irbid 21163, JordanFaculty of Pharmacy, Yarmouk University, P.O.BOX 566, Irbid 21163, JordanDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid 21163, JordanDepartment of Biological Science, Yarmouk University, P.O.BOX 566, Irbid 21163, JordanDepartment of Biological Science, Yarmouk University, P.O.BOX 566, Irbid 21163, JordanFaculty of Pharmacy, Yarmouk University, P.O.BOX 566, Irbid 21163, JordanSchool of Pharmacy, University of Jordan, Aljubeiha, Amman, Jordan 11942, JordanInstitute for Nanoscience, University of Arkansas, Fayetteville, AR 72701, USAJohn Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK(1) Background: There is a growing need for the development of new methods for the synthesis of nanoparticles. The interest in such particles has raised concerns about the environmental safety of their production methods; (2) Objectives: The current methods of nanoparticle production are often expensive and employ chemicals that are potentially harmful to the environment, which calls for the development of “greener” protocols. Herein we describe the synthesis of gold nanoparticles (AuNPs) using plant extracts, which offers an alternative, efficient, inexpensive, and environmentally friendly method to produce well-defined geometries of nanoparticles; (3) Methods: The phytochemicals present in the aqueous leaf extract acted as an effective reducing agent. The generated AuNPs were characterized by Transmission electron microscopy (TEM), Scanning electron microscope (SEM), and Atomic Force microscopy (AFM), X-ray diffraction (XRD), UV-visible spectroscopy, energy dispersive X-ray (EDX), and thermogravimetric analyses (TGA); (4) Results and Conclusions: The prepared nanoparticles were found to be biocompatible and exhibited no antimicrobial or antifungal effect, deeming the particles safe for various applications in nanomedicine. TGA analysis revealed that biomolecules, which were present in the plant extract, capped the nanoparticles and acted as stabilizing agents.http://www.mdpi.com/2079-4991/8/3/174biosynthesisgold nanoparticlesZiziphus zizyphusantifungal activitygreen chemistrynanomaterialsbiopharmaceutics |
| spellingShingle | Alaa A. A. Aljabali Yazan Akkam Mazhar Salim Al Zoubi Khalid M. Al-Batayneh Bahaa Al-Trad Osama Abo Alrob Alaaldin M. Alkilany Mourad Benamara David J. Evans Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity Nanomaterials biosynthesis gold nanoparticles Ziziphus zizyphus antifungal activity green chemistry nanomaterials biopharmaceutics |
| title | Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity |
| title_full | Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity |
| title_fullStr | Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity |
| title_full_unstemmed | Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity |
| title_short | Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity |
| title_sort | synthesis of gold nanoparticles using leaf extract of ziziphus zizyphus and their antimicrobial activity |
| topic | biosynthesis gold nanoparticles Ziziphus zizyphus antifungal activity green chemistry nanomaterials biopharmaceutics |
| url | http://www.mdpi.com/2079-4991/8/3/174 |
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