Effects of Selenium Supplementation on Incidence and Severity of Preeclampsia: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial
Background: Preeclampsia is a serious hypertensive condition of pregnancy associated with high maternal and fetal morbidity and mortality. In this study, the effect of selenium supplementation on the incidence and severity of preeclampsia in pregnant women was evaluated. Methods: The present double-...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences and Health Services
2023-02-01
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| Series: | Journal of Nutrition and Food Security |
| Subjects: | |
| Online Access: | http://jnfs.ssu.ac.ir/article-1-575-en.html |
| _version_ | 1811166159457746944 |
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| author | Fatemeh Mohsenpour Nahid Radnia Maryam Ahmadi Ziba Mohsenpour Maryam Jamali Mohammad Ali Mohsenpour |
| author_facet | Fatemeh Mohsenpour Nahid Radnia Maryam Ahmadi Ziba Mohsenpour Maryam Jamali Mohammad Ali Mohsenpour |
| author_sort | Fatemeh Mohsenpour |
| collection | DOAJ |
| description | Background: Preeclampsia is a serious hypertensive condition of pregnancy associated with high maternal and fetal morbidity and mortality. In this study, the effect of selenium supplementation on the incidence and severity of preeclampsia in pregnant women was evaluated. Methods: The present double-blind, placebo-controlled, parallel study was registered at Fatemieh Hospital of Hamadan, Iran. One hundred eighty women in the first trimesters of pregnancy were assigned to either selenium (SG, n = 90) or placebo (PG, n = 90) groups. SG and PG received 100 μg of selenium supplement or placebo per day, respectively. Results: In this study, no significant difference was observed between two groups in terms of age, body mass index, and serum selenium before the intervention (P > 0.05). The incidence of preeclampsia in the SG and PG was 9 and 5, respectively (P = 0.28). There was no statistically significant difference between sex and Apgar score of neonates in the two groups (P = 0.73). The mean birth weight, systolic and diastolic blood pressure in the SG was significantly higher than PG (P = 0.003, 0.01, and 0.007, respectively). The mean gestational age in the SG was insignificantly lower than the PG (P = 0.41). After the study, preeclampsia incidence was not significant between the groups (P = 0.28). Conclusion: The administration of 100 μg of selenium supplementation in pregnant women, had no effect on decreasing preeclampsia, but it may reduce the severity of preeclampsia. |
| first_indexed | 2024-04-10T15:48:06Z |
| format | Article |
| id | doaj.art-03ccde3e5b9a4872b129b55a4a36e409 |
| institution | Directory Open Access Journal |
| issn | 2476-7417 2476-7425 |
| language | English |
| last_indexed | 2024-04-10T15:48:06Z |
| publishDate | 2023-02-01 |
| publisher | Shahid Sadoughi University of Medical Sciences and Health Services |
| record_format | Article |
| series | Journal of Nutrition and Food Security |
| spelling | doaj.art-03ccde3e5b9a4872b129b55a4a36e4092023-02-12T03:41:36ZengShahid Sadoughi University of Medical Sciences and Health ServicesJournal of Nutrition and Food Security2476-74172476-74252023-02-0181122129Effects of Selenium Supplementation on Incidence and Severity of Preeclampsia: A Randomized, Double-Blind, Placebo-Controlled Pilot TrialFatemeh Mohsenpour0Nahid Radnia1Maryam Ahmadi2Ziba Mohsenpour3Maryam Jamali4Mohammad Ali Mohsenpour5 Department of Obstetrics and Gynecology, Fatemieh Hospital, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran Department of Obstetrics and Gynecology, Fatemieh Hospital, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran Department of Obstetrics and Gynecology, Fatemieh Hospital, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Department of Obstetrics and Gynecology, Fatemieh Hospital, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran Background: Preeclampsia is a serious hypertensive condition of pregnancy associated with high maternal and fetal morbidity and mortality. In this study, the effect of selenium supplementation on the incidence and severity of preeclampsia in pregnant women was evaluated. Methods: The present double-blind, placebo-controlled, parallel study was registered at Fatemieh Hospital of Hamadan, Iran. One hundred eighty women in the first trimesters of pregnancy were assigned to either selenium (SG, n = 90) or placebo (PG, n = 90) groups. SG and PG received 100 μg of selenium supplement or placebo per day, respectively. Results: In this study, no significant difference was observed between two groups in terms of age, body mass index, and serum selenium before the intervention (P > 0.05). The incidence of preeclampsia in the SG and PG was 9 and 5, respectively (P = 0.28). There was no statistically significant difference between sex and Apgar score of neonates in the two groups (P = 0.73). The mean birth weight, systolic and diastolic blood pressure in the SG was significantly higher than PG (P = 0.003, 0.01, and 0.007, respectively). The mean gestational age in the SG was insignificantly lower than the PG (P = 0.41). After the study, preeclampsia incidence was not significant between the groups (P = 0.28). Conclusion: The administration of 100 μg of selenium supplementation in pregnant women, had no effect on decreasing preeclampsia, but it may reduce the severity of preeclampsia.http://jnfs.ssu.ac.ir/article-1-575-en.htmlseleniumsupplementpreeclampsiapregnancyrct |
| spellingShingle | Fatemeh Mohsenpour Nahid Radnia Maryam Ahmadi Ziba Mohsenpour Maryam Jamali Mohammad Ali Mohsenpour Effects of Selenium Supplementation on Incidence and Severity of Preeclampsia: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial Journal of Nutrition and Food Security selenium supplement preeclampsia pregnancy rct |
| title | Effects of Selenium Supplementation on Incidence and Severity of Preeclampsia: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial |
| title_full | Effects of Selenium Supplementation on Incidence and Severity of Preeclampsia: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial |
| title_fullStr | Effects of Selenium Supplementation on Incidence and Severity of Preeclampsia: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial |
| title_full_unstemmed | Effects of Selenium Supplementation on Incidence and Severity of Preeclampsia: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial |
| title_short | Effects of Selenium Supplementation on Incidence and Severity of Preeclampsia: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial |
| title_sort | effects of selenium supplementation on incidence and severity of preeclampsia a randomized double blind placebo controlled pilot trial |
| topic | selenium supplement preeclampsia pregnancy rct |
| url | http://jnfs.ssu.ac.ir/article-1-575-en.html |
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