Outcomes and Risk Factor Analysis of Plastic Bronchitis Among 321 Children with Influenza Pneumonia After Bronchoscopy Examination
Qian Hu,1 Jianle Wu,1 Chengqian Wang,1 Wen Liang,1 Yulei Wang,1 Yuejie Zheng,1 Feiqiu Wen,2 Wenjian Wang,1,* Uet Yu2,* 1Department of Respiratory Diseases, Shenzhen Children’s Hospital, Shenzhen, People’s Republic of China; 2Department of Hematology and Oncology, Shenzhen Children’s...
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Dove Medical Press
2023-06-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/outcomes-and-risk-factor-analysis-of-plastic-bronchitis-among-321-chil-peer-reviewed-fulltext-article-IDR |
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| author | Hu Q Wu J Wang C Liang W Wang Y Zheng Y Wen F Wang W Yu U |
| author_facet | Hu Q Wu J Wang C Liang W Wang Y Zheng Y Wen F Wang W Yu U |
| author_sort | Hu Q |
| collection | DOAJ |
| description | Qian Hu,1 Jianle Wu,1 Chengqian Wang,1 Wen Liang,1 Yulei Wang,1 Yuejie Zheng,1 Feiqiu Wen,2 Wenjian Wang,1,* Uet Yu2,* 1Department of Respiratory Diseases, Shenzhen Children’s Hospital, Shenzhen, People’s Republic of China; 2Department of Hematology and Oncology, Shenzhen Children’s Hospital, Shenzhen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Uet Yu, Department of Hematology and Oncology, Shenzhen Children’s Hospital, 7019, Yitian, Road, Shenzhen, 518038, People’s Republic of China, Email cloveringo69@hotmail.com Wenjian Wang, Department of Respiratory Diseases, Shenzhen Children’s Hospital, 7019, Yitian, Road, Shenzhen, 518038, People’s Republic of China, Email wwjxx@126.comBackground: Plastic bronchitis (PB) is a rare and severe lung disease. It can be triggered by influenza virus infection, which is a common respiratory infection in children. Bronchoscopy can aid in the early detection and treatment of PB. However, the outcomes and risk for PB development in pediatric patients with influenza virus infection are not fully understood.Methods: Data from 321 children diagnosed with influenza virus pneumonia who underwent bronchoscopy examinations between 1st January, 2009 and 31st December, 2020 were retrospectively analyzed to assess the outcomes and risk factors associated with PB development.Results: This study included 97 girls and 224 boys with influenza virus pneumonia with a median age of 42 months. Among them, 36 patients (11.2%) were categorized as having PB based on bronchoscopy findings. PB patients had significantly longer fever durations (p=0.010) and higher risks of developing severe conditions including respiratory failure (p< 0.001), acute respiratory distress syndrome (p< 0.001), and air-leak syndrome (p< 0.001) compared to non-PB patients. Conventional treatment including the use of neuraminidase inhibitors and antibiotics did not differ between the PB and non-PB patients, but PB patients required more anti-inflammatory treatment (p=0.019) and ventilator support (p< 0.001). Combined univariate and multivariate analyses suggested that radiographic findings, including mediastinal emphysema (p=0.012) and lung consolidation (p=0.012), as well as increased levels of neutrophils (p=0.026), aspartate aminotransferase (p=0.004), and lactate dehydrogenase (p< 0.001), were identified as risk factors for PB development in patients with influenza virus pneumonia. Although PB patients required more intensive care and had longer hospital stays, they all recovered well after treatment.Conclusion: Influenza virus infection is linked to PB development in children. Identifying risk factors and early intervention such as bronchoscopy can improve the prognosis of children with PB.Keywords: influenza virus, plastic bronchitis, bronchoscopy, pneumonia, pediatric |
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| language | English |
| last_indexed | 2024-03-13T01:50:06Z |
| publishDate | 2023-06-01 |
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| series | Infection and Drug Resistance |
| spelling | doaj.art-03cd7e37922b45fea5f21b8a29c6f18a2023-07-02T19:49:16ZengDove Medical PressInfection and Drug Resistance1178-69732023-06-01Volume 164001401184627Outcomes and Risk Factor Analysis of Plastic Bronchitis Among 321 Children with Influenza Pneumonia After Bronchoscopy ExaminationHu QWu JWang CLiang WWang YZheng YWen FWang WYu UQian Hu,1 Jianle Wu,1 Chengqian Wang,1 Wen Liang,1 Yulei Wang,1 Yuejie Zheng,1 Feiqiu Wen,2 Wenjian Wang,1,* Uet Yu2,* 1Department of Respiratory Diseases, Shenzhen Children’s Hospital, Shenzhen, People’s Republic of China; 2Department of Hematology and Oncology, Shenzhen Children’s Hospital, Shenzhen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Uet Yu, Department of Hematology and Oncology, Shenzhen Children’s Hospital, 7019, Yitian, Road, Shenzhen, 518038, People’s Republic of China, Email cloveringo69@hotmail.com Wenjian Wang, Department of Respiratory Diseases, Shenzhen Children’s Hospital, 7019, Yitian, Road, Shenzhen, 518038, People’s Republic of China, Email wwjxx@126.comBackground: Plastic bronchitis (PB) is a rare and severe lung disease. It can be triggered by influenza virus infection, which is a common respiratory infection in children. Bronchoscopy can aid in the early detection and treatment of PB. However, the outcomes and risk for PB development in pediatric patients with influenza virus infection are not fully understood.Methods: Data from 321 children diagnosed with influenza virus pneumonia who underwent bronchoscopy examinations between 1st January, 2009 and 31st December, 2020 were retrospectively analyzed to assess the outcomes and risk factors associated with PB development.Results: This study included 97 girls and 224 boys with influenza virus pneumonia with a median age of 42 months. Among them, 36 patients (11.2%) were categorized as having PB based on bronchoscopy findings. PB patients had significantly longer fever durations (p=0.010) and higher risks of developing severe conditions including respiratory failure (p< 0.001), acute respiratory distress syndrome (p< 0.001), and air-leak syndrome (p< 0.001) compared to non-PB patients. Conventional treatment including the use of neuraminidase inhibitors and antibiotics did not differ between the PB and non-PB patients, but PB patients required more anti-inflammatory treatment (p=0.019) and ventilator support (p< 0.001). Combined univariate and multivariate analyses suggested that radiographic findings, including mediastinal emphysema (p=0.012) and lung consolidation (p=0.012), as well as increased levels of neutrophils (p=0.026), aspartate aminotransferase (p=0.004), and lactate dehydrogenase (p< 0.001), were identified as risk factors for PB development in patients with influenza virus pneumonia. Although PB patients required more intensive care and had longer hospital stays, they all recovered well after treatment.Conclusion: Influenza virus infection is linked to PB development in children. Identifying risk factors and early intervention such as bronchoscopy can improve the prognosis of children with PB.Keywords: influenza virus, plastic bronchitis, bronchoscopy, pneumonia, pediatrichttps://www.dovepress.com/outcomes-and-risk-factor-analysis-of-plastic-bronchitis-among-321-chil-peer-reviewed-fulltext-article-IDRinfluenza virusplastic bronchitisbronchoscopypneumoniapediatric |
| spellingShingle | Hu Q Wu J Wang C Liang W Wang Y Zheng Y Wen F Wang W Yu U Outcomes and Risk Factor Analysis of Plastic Bronchitis Among 321 Children with Influenza Pneumonia After Bronchoscopy Examination Infection and Drug Resistance influenza virus plastic bronchitis bronchoscopy pneumonia pediatric |
| title | Outcomes and Risk Factor Analysis of Plastic Bronchitis Among 321 Children with Influenza Pneumonia After Bronchoscopy Examination |
| title_full | Outcomes and Risk Factor Analysis of Plastic Bronchitis Among 321 Children with Influenza Pneumonia After Bronchoscopy Examination |
| title_fullStr | Outcomes and Risk Factor Analysis of Plastic Bronchitis Among 321 Children with Influenza Pneumonia After Bronchoscopy Examination |
| title_full_unstemmed | Outcomes and Risk Factor Analysis of Plastic Bronchitis Among 321 Children with Influenza Pneumonia After Bronchoscopy Examination |
| title_short | Outcomes and Risk Factor Analysis of Plastic Bronchitis Among 321 Children with Influenza Pneumonia After Bronchoscopy Examination |
| title_sort | outcomes and risk factor analysis of plastic bronchitis among 321 children with influenza pneumonia after bronchoscopy examination |
| topic | influenza virus plastic bronchitis bronchoscopy pneumonia pediatric |
| url | https://www.dovepress.com/outcomes-and-risk-factor-analysis-of-plastic-bronchitis-among-321-chil-peer-reviewed-fulltext-article-IDR |
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