Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humans
Since the domestication of dogs 10,000 years ago, they have shared their living environment with humans and have co-evolved. The breeding process that dogs have undergone in only a few centuries has led to a significant accumulation of specific genetic alterations that could induce particular diseas...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1250766/full |
| _version_ | 1797401457403625472 |
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| author | Kazuki Heishima Kazuki Heishima Naohiko Aketa Mizuki Heishima Asuka Kawachi Asuka Kawachi |
| author_facet | Kazuki Heishima Kazuki Heishima Naohiko Aketa Mizuki Heishima Asuka Kawachi Asuka Kawachi |
| author_sort | Kazuki Heishima |
| collection | DOAJ |
| description | Since the domestication of dogs 10,000 years ago, they have shared their living environment with humans and have co-evolved. The breeding process that dogs have undergone in only a few centuries has led to a significant accumulation of specific genetic alterations that could induce particular diseases in certain breeds. These canine diseases are similar to what is found in humans with several differences; therefore, comparing such diseases occurring in humans and dogs can help discover novel disease mechanisms, pathways, and causal genetic factors. Human angiosarcoma (AS) and canine hemangiosarcoma (HSA), which are sarcomas originating from endothelium, are examples of diseases shared between humans and dogs. They exhibit similar characteristics and clinical behaviors, although with some critical differences resulting from evolution. In this review, we will describe the similarities and differences in terms of clinical and molecular characteristics between human AS and canine HSA, and discuss how these similarities and differences can be applied to advance the treatment of these diseases. |
| first_indexed | 2024-03-09T02:10:21Z |
| format | Article |
| id | doaj.art-03ceb0d13eff4177bf5c807b29988614 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-09T02:10:21Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-03ceb0d13eff4177bf5c807b299886142023-12-07T12:06:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-12-011310.3389/fonc.2023.12507661250766Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humansKazuki Heishima0Kazuki Heishima1Naohiko Aketa2Mizuki Heishima3Asuka Kawachi4Asuka Kawachi5Institute for Advanced Study (GUiAS), Gifu University, Gifu, JapanCenter for One Medicine Innovative Translational Research (COMIT), Gifu University, Gifu, JapanClinical and Translational Research Center, Keio University Hospital, Tokyo, JapanIDEXX Laboratories, Tokyo, JapanDivision of Cancer RNA Research, National Cancer Center, Tokyo, JapanDepartment of Medical Oncology, National Cancer Center Hospital, Tokyo, JapanSince the domestication of dogs 10,000 years ago, they have shared their living environment with humans and have co-evolved. The breeding process that dogs have undergone in only a few centuries has led to a significant accumulation of specific genetic alterations that could induce particular diseases in certain breeds. These canine diseases are similar to what is found in humans with several differences; therefore, comparing such diseases occurring in humans and dogs can help discover novel disease mechanisms, pathways, and causal genetic factors. Human angiosarcoma (AS) and canine hemangiosarcoma (HSA), which are sarcomas originating from endothelium, are examples of diseases shared between humans and dogs. They exhibit similar characteristics and clinical behaviors, although with some critical differences resulting from evolution. In this review, we will describe the similarities and differences in terms of clinical and molecular characteristics between human AS and canine HSA, and discuss how these similarities and differences can be applied to advance the treatment of these diseases.https://www.frontiersin.org/articles/10.3389/fonc.2023.1250766/fullangiosarcomahemangiosarcomacancer heterogeneitynon-conventional animal modeldrug discovery |
| spellingShingle | Kazuki Heishima Kazuki Heishima Naohiko Aketa Mizuki Heishima Asuka Kawachi Asuka Kawachi Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humans Frontiers in Oncology angiosarcoma hemangiosarcoma cancer heterogeneity non-conventional animal model drug discovery |
| title | Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humans |
| title_full | Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humans |
| title_fullStr | Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humans |
| title_full_unstemmed | Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humans |
| title_short | Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humans |
| title_sort | hemangiosarcoma in dogs as a potential non rodent animal model for drug discovery research of angiosarcoma in humans |
| topic | angiosarcoma hemangiosarcoma cancer heterogeneity non-conventional animal model drug discovery |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1250766/full |
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