The regulation of apoptotic cell death
Apoptosis is a fundamental biological phenomenon in which the death of a cell is genetically and biochemically regulated. Different molecules are involved in the regulation of the apoptotic process. Death receptors, coupled to distinct members of the caspases as well as other adapter molecules, are...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
1999-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000900001 |
| _version_ | 1818131089980391424 |
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| author | Amarante-Mendes G.P. Green D.R. |
| author_facet | Amarante-Mendes G.P. Green D.R. |
| author_sort | Amarante-Mendes G.P. |
| collection | DOAJ |
| description | Apoptosis is a fundamental biological phenomenon in which the death of a cell is genetically and biochemically regulated. Different molecules are involved in the regulation of the apoptotic process. Death receptors, coupled to distinct members of the caspases as well as other adapter molecules, are involved in the initiation of the stress signals (The Indictment). Members of the Bcl-2 family control at the mitochondrial level the decision between life and death (The Judgement). The effector caspases are responsible for all morphological and biochemical changes related to apoptosis including the "eat-me" signals perceived by phagocytes and neighboring cells (The Execution). Finally, apoptosis would have little biological significance without the recognition and removal of the dying cells (The Burial). |
| first_indexed | 2024-12-11T08:15:24Z |
| format | Article |
| id | doaj.art-03ceed51229947e1a2786f12f7c20d81 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 0034-7310 |
| language | English |
| last_indexed | 2024-12-11T08:15:24Z |
| publishDate | 1999-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-03ceed51229947e1a2786f12f7c20d812022-12-22T01:14:47ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X0034-73101999-01-0132910531061The regulation of apoptotic cell deathAmarante-Mendes G.P.Green D.R.Apoptosis is a fundamental biological phenomenon in which the death of a cell is genetically and biochemically regulated. Different molecules are involved in the regulation of the apoptotic process. Death receptors, coupled to distinct members of the caspases as well as other adapter molecules, are involved in the initiation of the stress signals (The Indictment). Members of the Bcl-2 family control at the mitochondrial level the decision between life and death (The Judgement). The effector caspases are responsible for all morphological and biochemical changes related to apoptosis including the "eat-me" signals perceived by phagocytes and neighboring cells (The Execution). Finally, apoptosis would have little biological significance without the recognition and removal of the dying cells (The Burial).http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000900001apoptosiscell deathcaspasemitochondriaBcl-2oncogene |
| spellingShingle | Amarante-Mendes G.P. Green D.R. The regulation of apoptotic cell death Brazilian Journal of Medical and Biological Research apoptosis cell death caspase mitochondria Bcl-2 oncogene |
| title | The regulation of apoptotic cell death |
| title_full | The regulation of apoptotic cell death |
| title_fullStr | The regulation of apoptotic cell death |
| title_full_unstemmed | The regulation of apoptotic cell death |
| title_short | The regulation of apoptotic cell death |
| title_sort | regulation of apoptotic cell death |
| topic | apoptosis cell death caspase mitochondria Bcl-2 oncogene |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000900001 |
| work_keys_str_mv | AT amarantemendesgp theregulationofapoptoticcelldeath AT greendr theregulationofapoptoticcelldeath AT amarantemendesgp regulationofapoptoticcelldeath AT greendr regulationofapoptoticcelldeath |