Prognostic value of systemic immune inflammation index and geriatric nutrition risk index in early-onset colorectal cancer
BackgroundSystemic nutritional and inflammatory markers, which are easy to measure are associated with the progression and prognosis of many cancers. Nevertheless, among the various available indicators, optimal prognostic indicators for patients with early-onset colorectal cancer have not been iden...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1134300/full |
| _version_ | 1797844905173712896 |
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| author | Shuai Xiang Yu-Xiao Yang Wen-Jun Pan Ying Li Jun-Hao Zhang Yuan Gao Shanglong Liu |
| author_facet | Shuai Xiang Yu-Xiao Yang Wen-Jun Pan Ying Li Jun-Hao Zhang Yuan Gao Shanglong Liu |
| author_sort | Shuai Xiang |
| collection | DOAJ |
| description | BackgroundSystemic nutritional and inflammatory markers, which are easy to measure are associated with the progression and prognosis of many cancers. Nevertheless, among the various available indicators, optimal prognostic indicators for patients with early-onset colorectal cancer have not been identified. Therefore, the aim of this study was to identify optimal nutritional and inflammatory markers for early-onset colorectal cancer and examine the relationship between systemic nutritional and inflammatory markers before treatment and survival in patients with early-onset colorectal cancer.MethodsWe retrospectively collected data from 236 eligible patients with early-onset colorectal cancer. Area under the prognostic curve (AUC) and concordance index (C-index) were used to compare seven systemic nutritional and inflammatory markers to identify the optimal inflammatory immune markers. Univariate and multivariate COX regression analyses were used to evaluate the prognostic value of indicators in the total study population and different subgroups.ResultsThe AUC and C-index showed that the systemic immune inflammation index (SII) and geriatric nutrition risk index (GNRI) had higher prognostic values than other systemic nutritional and inflammatory indicators. Compared with patients in the low SII group, those in the high SII group had lower overall survival (HR, 4.42, 95% CI, 2.36–8.27, p = 0.000). Compared with patients in the high GNRI group, those in the low GNRI group had lower overall survival (HR, 0.33, 95% CI, 0.19–0.56, p = 0.000). SII was negatively associated with GNRI (R = −0.3, p < 0.001), and both were correlated with the tumor stage.ConclusionSII and GNRI are suitable nutritional and inflammatory factors for predicting OS in patients with early-onset colorectal cancer; high SII and low GNRI were correlated with worse prognoses. Identifying the high inflammatory state and low nutritional state of patients before surgery and conducting active and timely therapeutic interventions could improve patient prognosis. |
| first_indexed | 2024-04-09T17:31:00Z |
| format | Article |
| id | doaj.art-03d0d38f6f714d27854595ed14af5b8d |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-09T17:31:00Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-03d0d38f6f714d27854595ed14af5b8d2023-04-18T05:25:09ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-04-011010.3389/fnut.2023.11343001134300Prognostic value of systemic immune inflammation index and geriatric nutrition risk index in early-onset colorectal cancerShuai Xiang0Yu-Xiao Yang1Wen-Jun Pan2Ying Li3Jun-Hao Zhang4Yuan Gao5Shanglong Liu6Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Gastroenterology, China-Japan Friendship Hospital of Peking University, Beijing, ChinaDepartment of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Blood Transfusion, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, ChinaBackgroundSystemic nutritional and inflammatory markers, which are easy to measure are associated with the progression and prognosis of many cancers. Nevertheless, among the various available indicators, optimal prognostic indicators for patients with early-onset colorectal cancer have not been identified. Therefore, the aim of this study was to identify optimal nutritional and inflammatory markers for early-onset colorectal cancer and examine the relationship between systemic nutritional and inflammatory markers before treatment and survival in patients with early-onset colorectal cancer.MethodsWe retrospectively collected data from 236 eligible patients with early-onset colorectal cancer. Area under the prognostic curve (AUC) and concordance index (C-index) were used to compare seven systemic nutritional and inflammatory markers to identify the optimal inflammatory immune markers. Univariate and multivariate COX regression analyses were used to evaluate the prognostic value of indicators in the total study population and different subgroups.ResultsThe AUC and C-index showed that the systemic immune inflammation index (SII) and geriatric nutrition risk index (GNRI) had higher prognostic values than other systemic nutritional and inflammatory indicators. Compared with patients in the low SII group, those in the high SII group had lower overall survival (HR, 4.42, 95% CI, 2.36–8.27, p = 0.000). Compared with patients in the high GNRI group, those in the low GNRI group had lower overall survival (HR, 0.33, 95% CI, 0.19–0.56, p = 0.000). SII was negatively associated with GNRI (R = −0.3, p < 0.001), and both were correlated with the tumor stage.ConclusionSII and GNRI are suitable nutritional and inflammatory factors for predicting OS in patients with early-onset colorectal cancer; high SII and low GNRI were correlated with worse prognoses. Identifying the high inflammatory state and low nutritional state of patients before surgery and conducting active and timely therapeutic interventions could improve patient prognosis.https://www.frontiersin.org/articles/10.3389/fnut.2023.1134300/fullsystemic inflammationearly-onset colorectal canceroverall survivalSIIGNRI |
| spellingShingle | Shuai Xiang Yu-Xiao Yang Wen-Jun Pan Ying Li Jun-Hao Zhang Yuan Gao Shanglong Liu Prognostic value of systemic immune inflammation index and geriatric nutrition risk index in early-onset colorectal cancer Frontiers in Nutrition systemic inflammation early-onset colorectal cancer overall survival SII GNRI |
| title | Prognostic value of systemic immune inflammation index and geriatric nutrition risk index in early-onset colorectal cancer |
| title_full | Prognostic value of systemic immune inflammation index and geriatric nutrition risk index in early-onset colorectal cancer |
| title_fullStr | Prognostic value of systemic immune inflammation index and geriatric nutrition risk index in early-onset colorectal cancer |
| title_full_unstemmed | Prognostic value of systemic immune inflammation index and geriatric nutrition risk index in early-onset colorectal cancer |
| title_short | Prognostic value of systemic immune inflammation index and geriatric nutrition risk index in early-onset colorectal cancer |
| title_sort | prognostic value of systemic immune inflammation index and geriatric nutrition risk index in early onset colorectal cancer |
| topic | systemic inflammation early-onset colorectal cancer overall survival SII GNRI |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1134300/full |
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