RNA regulatory elements and polyadenylation in plants
Alternative poly(A) site choice (also known as alternative polyadenylation, or APA) has the potential to affect gene expression in qualitative and quantitative ways. Alternative polyadenylation may affect as many as 82% of all expressed genes in a plant. The consequences of APA include the generat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-01-01
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| Series: | Frontiers in Plant Science |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpls.2011.00109/full |
| _version_ | 1818852917239611392 |
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| author | Arthur G. Hunt |
| author_facet | Arthur G. Hunt |
| author_sort | Arthur G. Hunt |
| collection | DOAJ |
| description | Alternative poly(A) site choice (also known as alternative polyadenylation, or APA) has the potential to affect gene expression in qualitative and quantitative ways. Alternative polyadenylation may affect as many as 82% of all expressed genes in a plant. The consequences of APA include the generation of transcripts with differing 3’-UTRs (and thus differing potential regulatory potential) and of transcripts with differing protein-coding potential. Genome-wide studies of possible APA suggest a linkage with pre-mRNA splicing, and indicate a coincidence of and perhaps cooperation between RNA regulatory elements that affect splicing efficiency and the recognition of novel intronic poly(A) sites. These studies also raise the possibility of the existence of a novel class of polyadenylation-related cis elements that are distinct from the well-characterized plant polyadenylation signal. Many potential APA events, however, have not been associated with identifiable cis elements. The present state of the field reveals a broad scope of APA, and also numerous opportunities for research into mechanisms that govern both choice and regulation of poly(A) sites in plants. |
| first_indexed | 2024-12-19T07:28:32Z |
| format | Article |
| id | doaj.art-03d150da95b24920934ea7ff6a69cf27 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-19T07:28:32Z |
| publishDate | 2012-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-03d150da95b24920934ea7ff6a69cf272022-12-21T20:30:47ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2012-01-01210.3389/fpls.2011.0010918232RNA regulatory elements and polyadenylation in plantsArthur G. Hunt0University of KentuckyAlternative poly(A) site choice (also known as alternative polyadenylation, or APA) has the potential to affect gene expression in qualitative and quantitative ways. Alternative polyadenylation may affect as many as 82% of all expressed genes in a plant. The consequences of APA include the generation of transcripts with differing 3’-UTRs (and thus differing potential regulatory potential) and of transcripts with differing protein-coding potential. Genome-wide studies of possible APA suggest a linkage with pre-mRNA splicing, and indicate a coincidence of and perhaps cooperation between RNA regulatory elements that affect splicing efficiency and the recognition of novel intronic poly(A) sites. These studies also raise the possibility of the existence of a novel class of polyadenylation-related cis elements that are distinct from the well-characterized plant polyadenylation signal. Many potential APA events, however, have not been associated with identifiable cis elements. The present state of the field reveals a broad scope of APA, and also numerous opportunities for research into mechanisms that govern both choice and regulation of poly(A) sites in plants.http://journal.frontiersin.org/Journal/10.3389/fpls.2011.00109/fullExonsIntronsSplicingalternative polyadenylationUTRs |
| spellingShingle | Arthur G. Hunt RNA regulatory elements and polyadenylation in plants Frontiers in Plant Science Exons Introns Splicing alternative polyadenylation UTRs |
| title | RNA regulatory elements and polyadenylation in plants |
| title_full | RNA regulatory elements and polyadenylation in plants |
| title_fullStr | RNA regulatory elements and polyadenylation in plants |
| title_full_unstemmed | RNA regulatory elements and polyadenylation in plants |
| title_short | RNA regulatory elements and polyadenylation in plants |
| title_sort | rna regulatory elements and polyadenylation in plants |
| topic | Exons Introns Splicing alternative polyadenylation UTRs |
| url | http://journal.frontiersin.org/Journal/10.3389/fpls.2011.00109/full |
| work_keys_str_mv | AT arthurghunt rnaregulatoryelementsandpolyadenylationinplants |