Fractal Dimension and Texture Analysis of Lesion Autofluorescence in the Evaluation of Oral Lichen Planus Treatment Effectiveness
Background: Oral Lichen planus (OLP) is a chronic inflammatory disease. Topical steroids are used as the treatment of choice. The alternative is photodynamic therapy (PDT). The study aimed to fabricate optimal biodegradable matrices for methylene blue or triamcinolone acetonide because of a lack of...
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| author | Kamil Jurczyszyn Witold Trzeciakowski Marcin Kozakiewicz Dorota Kida Katarzyna Malec Bożena Karolewicz Tomasz Konopka Jacek Zborowski |
| author_facet | Kamil Jurczyszyn Witold Trzeciakowski Marcin Kozakiewicz Dorota Kida Katarzyna Malec Bożena Karolewicz Tomasz Konopka Jacek Zborowski |
| author_sort | Kamil Jurczyszyn |
| collection | DOAJ |
| description | Background: Oral Lichen planus (OLP) is a chronic inflammatory disease. Topical steroids are used as the treatment of choice. The alternative is photodynamic therapy (PDT). The study aimed to fabricate optimal biodegradable matrices for methylene blue or triamcinolone acetonide because of a lack of currently commercially available carriers that could adhere to the mucous. Methods: The study was designed as a 12-week single-blind prospective randomized clinical trial with 30 patients, full contralateral split-mouth design. Matrices for steroid and photosensitizer and laser device were fabricated. Fractal and texture analysis of photographs, taken in 405, 450, 405 + 450 nm wavelength, of lesions was performed to increase the objectivity of the assessment of treatment. Results: We achieved two total responses for treatment in case of steroid therapy and one in the case of PDT. Partial response was noted in 17 lesions treated using local steroid therapy and 21 in the case of PDT. No statistically significant differences were found between the effectiveness of both used methods. Statistically significant differences in fractal dimension before and after treatment were observed only in the analysis of photographs taken in 405 + 450 nm wavelength. Conclusions: Photodynamic therapy and topical steroid therapy are effective methods for treating OLP. Using a carrier offers the possibility of a more predictable and effective method of drug delivery into the mucous membrane. Autofluorescence enables the detection of lesions especially at the early stage of their development. |
| first_indexed | 2024-03-10T07:28:36Z |
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| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T07:28:36Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-03d186d9038e4236bf0b9f8956f7e51b2023-11-22T14:04:13ZengMDPI AGMaterials1996-19442021-09-011418544810.3390/ma14185448Fractal Dimension and Texture Analysis of Lesion Autofluorescence in the Evaluation of Oral Lichen Planus Treatment EffectivenessKamil Jurczyszyn0Witold Trzeciakowski1Marcin Kozakiewicz2Dorota Kida3Katarzyna Malec4Bożena Karolewicz5Tomasz Konopka6Jacek Zborowski7Department of Oral Surgery, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, PolandInstitute of High Pressure Physics, Polish Academy of Sciences, 01-142 Warsaw, PolandDepartment of Maxillofacial Surgery, Medical University of Lodz, 113 S. Zeromski Street, 90-549 Lodz, PolandDepartment of Drugs Form Technology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, PolandDepartment of Drugs Form Technology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, PolandDepartment of Drugs Form Technology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, PolandDepartment of Periodontology, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, PolandDepartment of Periodontology, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, PolandBackground: Oral Lichen planus (OLP) is a chronic inflammatory disease. Topical steroids are used as the treatment of choice. The alternative is photodynamic therapy (PDT). The study aimed to fabricate optimal biodegradable matrices for methylene blue or triamcinolone acetonide because of a lack of currently commercially available carriers that could adhere to the mucous. Methods: The study was designed as a 12-week single-blind prospective randomized clinical trial with 30 patients, full contralateral split-mouth design. Matrices for steroid and photosensitizer and laser device were fabricated. Fractal and texture analysis of photographs, taken in 405, 450, 405 + 450 nm wavelength, of lesions was performed to increase the objectivity of the assessment of treatment. Results: We achieved two total responses for treatment in case of steroid therapy and one in the case of PDT. Partial response was noted in 17 lesions treated using local steroid therapy and 21 in the case of PDT. No statistically significant differences were found between the effectiveness of both used methods. Statistically significant differences in fractal dimension before and after treatment were observed only in the analysis of photographs taken in 405 + 450 nm wavelength. Conclusions: Photodynamic therapy and topical steroid therapy are effective methods for treating OLP. Using a carrier offers the possibility of a more predictable and effective method of drug delivery into the mucous membrane. Autofluorescence enables the detection of lesions especially at the early stage of their development.https://www.mdpi.com/1996-1944/14/18/5448photodynamic therapytopical steroidoral lichen planusfractal dimensiontexture analysisautofluorescence |
| spellingShingle | Kamil Jurczyszyn Witold Trzeciakowski Marcin Kozakiewicz Dorota Kida Katarzyna Malec Bożena Karolewicz Tomasz Konopka Jacek Zborowski Fractal Dimension and Texture Analysis of Lesion Autofluorescence in the Evaluation of Oral Lichen Planus Treatment Effectiveness Materials photodynamic therapy topical steroid oral lichen planus fractal dimension texture analysis autofluorescence |
| title | Fractal Dimension and Texture Analysis of Lesion Autofluorescence in the Evaluation of Oral Lichen Planus Treatment Effectiveness |
| title_full | Fractal Dimension and Texture Analysis of Lesion Autofluorescence in the Evaluation of Oral Lichen Planus Treatment Effectiveness |
| title_fullStr | Fractal Dimension and Texture Analysis of Lesion Autofluorescence in the Evaluation of Oral Lichen Planus Treatment Effectiveness |
| title_full_unstemmed | Fractal Dimension and Texture Analysis of Lesion Autofluorescence in the Evaluation of Oral Lichen Planus Treatment Effectiveness |
| title_short | Fractal Dimension and Texture Analysis of Lesion Autofluorescence in the Evaluation of Oral Lichen Planus Treatment Effectiveness |
| title_sort | fractal dimension and texture analysis of lesion autofluorescence in the evaluation of oral lichen planus treatment effectiveness |
| topic | photodynamic therapy topical steroid oral lichen planus fractal dimension texture analysis autofluorescence |
| url | https://www.mdpi.com/1996-1944/14/18/5448 |
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