Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity
The maturation of inhibitory GABAergic cortical circuits regulates experience-dependent plasticity. We recently showed that the heterochronic transplantation of parvalbumin (PV) or somatostatin (SST) interneurons from the medial ganglionic eminence (MGE) reactivates ocular dominance plasticity (ODP)...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-08-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124716308403 |
| _version_ | 1819069648013885440 |
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| author | Phillip Larimer Julien Spatazza Juan Sebastian Espinosa Yunshuo Tang Megumi Kaneko Andrea R. Hasenstaub Michael P. Stryker Arturo Alvarez-Buylla |
| author_facet | Phillip Larimer Julien Spatazza Juan Sebastian Espinosa Yunshuo Tang Megumi Kaneko Andrea R. Hasenstaub Michael P. Stryker Arturo Alvarez-Buylla |
| author_sort | Phillip Larimer |
| collection | DOAJ |
| description | The maturation of inhibitory GABAergic cortical circuits regulates experience-dependent plasticity. We recently showed that the heterochronic transplantation of parvalbumin (PV) or somatostatin (SST) interneurons from the medial ganglionic eminence (MGE) reactivates ocular dominance plasticity (ODP) in the postnatal mouse visual cortex. Might other types of interneurons similarly induce cortical plasticity? Here, we establish that caudal ganglionic eminence (CGE)-derived interneurons, when transplanted into the visual cortex of neonatal mice, migrate extensively in the host brain and acquire laminar distribution, marker expression, electrophysiological properties, and visual response properties like those of host CGE interneurons. Although transplants from the anatomical CGE do induce ODP, we found that this plasticity reactivation is mediated by a small fraction of MGE-derived cells contained in the transplant. These findings demonstrate that transplanted CGE cells can successfully engraft into the postnatal mouse brain and confirm the unique role of MGE lineage neurons in the induction of ODP. |
| first_indexed | 2024-12-21T16:53:23Z |
| format | Article |
| id | doaj.art-03d1e39139d14adda794e01ee949693e |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-21T16:53:23Z |
| publishDate | 2016-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-03d1e39139d14adda794e01ee949693e2022-12-21T18:56:49ZengElsevierCell Reports2211-12472016-08-011651391140410.1016/j.celrep.2016.06.071Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical PlasticityPhillip Larimer0Julien Spatazza1Juan Sebastian Espinosa2Yunshuo Tang3Megumi Kaneko4Andrea R. Hasenstaub5Michael P. Stryker6Arturo Alvarez-Buylla7Center for Integrative Neuroscience, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USADepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USACenter for Integrative Neuroscience, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USADepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USACenter for Integrative Neuroscience, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USACenter for Integrative Neuroscience, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USACenter for Integrative Neuroscience, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USADepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USAThe maturation of inhibitory GABAergic cortical circuits regulates experience-dependent plasticity. We recently showed that the heterochronic transplantation of parvalbumin (PV) or somatostatin (SST) interneurons from the medial ganglionic eminence (MGE) reactivates ocular dominance plasticity (ODP) in the postnatal mouse visual cortex. Might other types of interneurons similarly induce cortical plasticity? Here, we establish that caudal ganglionic eminence (CGE)-derived interneurons, when transplanted into the visual cortex of neonatal mice, migrate extensively in the host brain and acquire laminar distribution, marker expression, electrophysiological properties, and visual response properties like those of host CGE interneurons. Although transplants from the anatomical CGE do induce ODP, we found that this plasticity reactivation is mediated by a small fraction of MGE-derived cells contained in the transplant. These findings demonstrate that transplanted CGE cells can successfully engraft into the postnatal mouse brain and confirm the unique role of MGE lineage neurons in the induction of ODP.http://www.sciencedirect.com/science/article/pii/S2211124716308403medial ganglionic eminencecaudal ganglionic eminenceVIP interneuroncritical periodocular dominance plasticity |
| spellingShingle | Phillip Larimer Julien Spatazza Juan Sebastian Espinosa Yunshuo Tang Megumi Kaneko Andrea R. Hasenstaub Michael P. Stryker Arturo Alvarez-Buylla Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity Cell Reports medial ganglionic eminence caudal ganglionic eminence VIP interneuron critical period ocular dominance plasticity |
| title | Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity |
| title_full | Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity |
| title_fullStr | Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity |
| title_full_unstemmed | Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity |
| title_short | Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity |
| title_sort | caudal ganglionic eminence precursor transplants disperse and integrate as lineage specific interneurons but do not induce cortical plasticity |
| topic | medial ganglionic eminence caudal ganglionic eminence VIP interneuron critical period ocular dominance plasticity |
| url | http://www.sciencedirect.com/science/article/pii/S2211124716308403 |
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