Multi-omics analyses of early liver injury reveals cell-type-specific transcriptional and epigenomic shift

Multi-omics analyses of early liver injury reveals cell-type-specific transcriptional and epigenomic shift

Abstract Background Liver fibrosis is a wound-healing response to tissue injury and inflammation hallmarked by the extracellular matrix (ECM) protein deposition in the liver parenchyma and tissue remodelling. Different cell types of the liver are known to play distinct roles in liver injury response...

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Bibliographic Details
Main Authors: Maciej Migdał, Eugeniusz Tralle, Karim Abu Nahia, Łukasz Bugajski, Katarzyna Zofia Kędzierska, Filip Garbicz, Katarzyna Piwocka, Cecilia Lanny Winata, Michał Pawlak
Format: Article
Language:English
Published: BMC 2021-12-01
Series:BMC Genomics
Subjects:
Liver
Hepatocytes
Stellate cells
Endothelial cells
Chromatin
Transcriptomics
Online Access:https://doi.org/10.1186/s12864-021-08173-1

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