Salmonella enterica serovar Typhimurium exploits inflammation to modify swine intestinal microbiota.
Salmonella enterica serovar Typhimurium is an important zoonotic gastrointestinal pathogen responsible for foodborne disease worldwide. It is a successful enteric pathogen because it has developed virulence strategies allowing it to survive in a highly inflamed intestinal environment exploiting infl...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2015.00106/full |
| _version_ | 1811241235059310592 |
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| author | Rosanna eDrumo Rosanna eDrumo Michele ePesciaroli Michele ePesciaroli Jessica eRuggeri Michela eTarantino Barbara eChirullo Claudia ePistoia Paola ePetrucci Nicola eMartinelli Livia eMoscati Elisabetta eManuali Silvia ePavone Matteo ePicciolini Serena eAmmendola Gianfranco eGabai Andrea eBattistoni Giovanni ePezzotti Giovanni Loris Alborali Valerio eNapolioni Paolo ePasquali Chiara Francesca eMagistrali |
| author_facet | Rosanna eDrumo Rosanna eDrumo Michele ePesciaroli Michele ePesciaroli Jessica eRuggeri Michela eTarantino Barbara eChirullo Claudia ePistoia Paola ePetrucci Nicola eMartinelli Livia eMoscati Elisabetta eManuali Silvia ePavone Matteo ePicciolini Serena eAmmendola Gianfranco eGabai Andrea eBattistoni Giovanni ePezzotti Giovanni Loris Alborali Valerio eNapolioni Paolo ePasquali Chiara Francesca eMagistrali |
| author_sort | Rosanna eDrumo |
| collection | DOAJ |
| description | Salmonella enterica serovar Typhimurium is an important zoonotic gastrointestinal pathogen responsible for foodborne disease worldwide. It is a successful enteric pathogen because it has developed virulence strategies allowing it to survive in a highly inflamed intestinal environment exploiting inflammation to overcome colonization resistance provided by intestinal microbiota. In this study, we used piglets featuring an intact microbiota, which naturally develop gastroenteritis, as model for salmonellosis. We compared the effects on the intestinal microbiota induced by a wild type and an attenuated S. Typhimurium in order to evaluate whether the modifications are correlated with the virulence of the strain. This study showed that Salmonella alters microbiota in a virulence-dependent manner. We found that the wild type S. Typhimurium induced inflammation and a reduction of specific protecting microbiota species (SCFA-producing bacteria) normally involved in providing a barrier against pathogens. Both these effects could contribute to impair colonization resistance, increasing the host susceptibility to wild type S. Typhimurium colonization. In contrast, the attenuated S. Typhimurium, which is characterized by a reduced ability to colonize the intestine, and by a very mild inflammatory response, was unable to successfully sustain competition with the microbiota. |
| first_indexed | 2024-04-12T13:33:25Z |
| format | Article |
| id | doaj.art-03d3a955f96b45038a63f5fce33e31fe |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-12T13:33:25Z |
| publishDate | 2016-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-03d3a955f96b45038a63f5fce33e31fe2022-12-22T03:31:06ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882016-01-01510.3389/fcimb.2015.00106164512Salmonella enterica serovar Typhimurium exploits inflammation to modify swine intestinal microbiota.Rosanna eDrumo0Rosanna eDrumo1Michele ePesciaroli2Michele ePesciaroli3Jessica eRuggeri4Michela eTarantino5Barbara eChirullo6Claudia ePistoia7Paola ePetrucci8Nicola eMartinelli9Livia eMoscati10Elisabetta eManuali11Silvia ePavone12Matteo ePicciolini13Serena eAmmendola14Gianfranco eGabai15Andrea eBattistoni16Giovanni ePezzotti17Giovanni Loris Alborali18Valerio eNapolioni19Paolo ePasquali20Chiara Francesca eMagistrali21Istituto Superiore di SanitàUniversity of PadovaIstituto Superiore di SanitàVISAVET Health Surveillance Centre, Universidad Complutense MadridIstituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia RomagnaIstituto Superiore di SanitàIstituto Superiore di SanitàIstituto Superiore di SanitàIstituto Superiore di SanitàIstituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia RomagnaIstituto Zooprofilattico Sperimentale dell'Umbria e delle MarcheIstituto Zooprofilattico Sperimentale dell'Umbria e delle MarcheIstituto Zooprofilattico Sperimentale dell'Umbria e delle MarcheUniversity of PerugiaUniversity of Roma Tor VergataUniversity of PadovaUniversity of Roma Tor VergataIstituto Zooprofilattico Sperimentale dell'Umbria e delle MarcheIstituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia RomagnaUniversity of PerugiaIstituto Superiore di SanitàIstituto Zooprofilattico Sperimentale dell'Umbria e delle MarcheSalmonella enterica serovar Typhimurium is an important zoonotic gastrointestinal pathogen responsible for foodborne disease worldwide. It is a successful enteric pathogen because it has developed virulence strategies allowing it to survive in a highly inflamed intestinal environment exploiting inflammation to overcome colonization resistance provided by intestinal microbiota. In this study, we used piglets featuring an intact microbiota, which naturally develop gastroenteritis, as model for salmonellosis. We compared the effects on the intestinal microbiota induced by a wild type and an attenuated S. Typhimurium in order to evaluate whether the modifications are correlated with the virulence of the strain. This study showed that Salmonella alters microbiota in a virulence-dependent manner. We found that the wild type S. Typhimurium induced inflammation and a reduction of specific protecting microbiota species (SCFA-producing bacteria) normally involved in providing a barrier against pathogens. Both these effects could contribute to impair colonization resistance, increasing the host susceptibility to wild type S. Typhimurium colonization. In contrast, the attenuated S. Typhimurium, which is characterized by a reduced ability to colonize the intestine, and by a very mild inflammatory response, was unable to successfully sustain competition with the microbiota.http://journal.frontiersin.org/Journal/10.3389/fcimb.2015.00106/fullInflammationSalmonella typhimuriummicrobiotaimmune responsepigsalmonellosis |
| spellingShingle | Rosanna eDrumo Rosanna eDrumo Michele ePesciaroli Michele ePesciaroli Jessica eRuggeri Michela eTarantino Barbara eChirullo Claudia ePistoia Paola ePetrucci Nicola eMartinelli Livia eMoscati Elisabetta eManuali Silvia ePavone Matteo ePicciolini Serena eAmmendola Gianfranco eGabai Andrea eBattistoni Giovanni ePezzotti Giovanni Loris Alborali Valerio eNapolioni Paolo ePasquali Chiara Francesca eMagistrali Salmonella enterica serovar Typhimurium exploits inflammation to modify swine intestinal microbiota. Frontiers in Cellular and Infection Microbiology Inflammation Salmonella typhimurium microbiota immune response pig salmonellosis |
| title | Salmonella enterica serovar Typhimurium exploits inflammation to modify swine intestinal microbiota. |
| title_full | Salmonella enterica serovar Typhimurium exploits inflammation to modify swine intestinal microbiota. |
| title_fullStr | Salmonella enterica serovar Typhimurium exploits inflammation to modify swine intestinal microbiota. |
| title_full_unstemmed | Salmonella enterica serovar Typhimurium exploits inflammation to modify swine intestinal microbiota. |
| title_short | Salmonella enterica serovar Typhimurium exploits inflammation to modify swine intestinal microbiota. |
| title_sort | salmonella enterica serovar typhimurium exploits inflammation to modify swine intestinal microbiota |
| topic | Inflammation Salmonella typhimurium microbiota immune response pig salmonellosis |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2015.00106/full |
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