The Effect of Selective Retina Therapy with Automatic Real-Time Feedback-Controlled Dosimetry for Chronic Central Serous Chorioretinopathy: A Randomized, Open-Label, Controlled Clinical Trial
This prospective randomized controlled trial evaluated the safety and efficacy of real-time feedback-controlled dosimetry (RFD)-guided selective retina therapy (SRT) in chronic central serous chorioretinopathy (CSC). Forty-four participants with chronic CSC were included and randomly assigned to the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/19/4295 |
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| author | Ji-young Lee Min-hee Kim Seung-hee Jeon Seung-hoon Lee Young-jung Roh |
| author_facet | Ji-young Lee Min-hee Kim Seung-hee Jeon Seung-hoon Lee Young-jung Roh |
| author_sort | Ji-young Lee |
| collection | DOAJ |
| description | This prospective randomized controlled trial evaluated the safety and efficacy of real-time feedback-controlled dosimetry (RFD)-guided selective retina therapy (SRT) in chronic central serous chorioretinopathy (CSC). Forty-four participants with chronic CSC were included and randomly assigned to the control group or SRT group. The SRT laser system with RFD-guidance was applied to cover the entire leakage area. If SRF remained at the 6-week follow-up visit, re-treatment and rescue SRT was performed for the SRT group and crossover group, respectively. The rate of complete resolution of subretinal fluid (SRF), mean SRF height, and mean retinal sensitivity were compared between the two groups at 6-weeks post-treatment. The complete SRF resolution rate in all SRT-treated eyes was evaluated at 12-weeks post-treatment. The rate of complete SRF resolution was significantly higher in the SRT group (63.6%) than in the control group (23.8%) at 6-weeks post-treatment (<i>p</i> = 0.020). The mean SRF height at 6 weeks after SRT was significantly lower in the SRT group (<i>p</i> = 0.041). Overall, SRT-treated eyes showed complete SRF resolution in 70.3% of eyes at 12-weeks post-treatment. RFD-guided SRT was safe and effective to remove SRF in chronic CSC patients during the 3-month follow-up period. |
| first_indexed | 2024-03-10T06:57:32Z |
| format | Article |
| id | doaj.art-03d4c79a04044c16a6737602d1a6d467 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T06:57:32Z |
| publishDate | 2021-09-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-03d4c79a04044c16a6737602d1a6d4672023-11-22T16:17:16ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011019429510.3390/jcm10194295The Effect of Selective Retina Therapy with Automatic Real-Time Feedback-Controlled Dosimetry for Chronic Central Serous Chorioretinopathy: A Randomized, Open-Label, Controlled Clinical TrialJi-young Lee0Min-hee Kim1Seung-hee Jeon2Seung-hoon Lee3Young-jung Roh4Department of Ophthalmology and Visual Science, Yeouido St. Mary’s Hospital, College of Medicine, Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul 07345, KoreaDepartment of Ophthalmology and Visual Science, Yeouido St. Mary’s Hospital, College of Medicine, Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul 07345, KoreaDepartment of Ophthalmology and Visual Science, Incheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, 56, Dongsu-ro, Bupyeong-gu, Incheon 21431, KoreaDepartment of Ophthalmology and Visual Science, Yeouido St. Mary’s Hospital, College of Medicine, Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul 07345, KoreaDepartment of Ophthalmology and Visual Science, Yeouido St. Mary’s Hospital, College of Medicine, Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul 07345, KoreaThis prospective randomized controlled trial evaluated the safety and efficacy of real-time feedback-controlled dosimetry (RFD)-guided selective retina therapy (SRT) in chronic central serous chorioretinopathy (CSC). Forty-four participants with chronic CSC were included and randomly assigned to the control group or SRT group. The SRT laser system with RFD-guidance was applied to cover the entire leakage area. If SRF remained at the 6-week follow-up visit, re-treatment and rescue SRT was performed for the SRT group and crossover group, respectively. The rate of complete resolution of subretinal fluid (SRF), mean SRF height, and mean retinal sensitivity were compared between the two groups at 6-weeks post-treatment. The complete SRF resolution rate in all SRT-treated eyes was evaluated at 12-weeks post-treatment. The rate of complete SRF resolution was significantly higher in the SRT group (63.6%) than in the control group (23.8%) at 6-weeks post-treatment (<i>p</i> = 0.020). The mean SRF height at 6 weeks after SRT was significantly lower in the SRT group (<i>p</i> = 0.041). Overall, SRT-treated eyes showed complete SRF resolution in 70.3% of eyes at 12-weeks post-treatment. RFD-guided SRT was safe and effective to remove SRF in chronic CSC patients during the 3-month follow-up period.https://www.mdpi.com/2077-0383/10/19/4295central serous chorioretinopathyreal-time feedback-controlled dosimetryretinal sensitivityselective retina therapy |
| spellingShingle | Ji-young Lee Min-hee Kim Seung-hee Jeon Seung-hoon Lee Young-jung Roh The Effect of Selective Retina Therapy with Automatic Real-Time Feedback-Controlled Dosimetry for Chronic Central Serous Chorioretinopathy: A Randomized, Open-Label, Controlled Clinical Trial Journal of Clinical Medicine central serous chorioretinopathy real-time feedback-controlled dosimetry retinal sensitivity selective retina therapy |
| title | The Effect of Selective Retina Therapy with Automatic Real-Time Feedback-Controlled Dosimetry for Chronic Central Serous Chorioretinopathy: A Randomized, Open-Label, Controlled Clinical Trial |
| title_full | The Effect of Selective Retina Therapy with Automatic Real-Time Feedback-Controlled Dosimetry for Chronic Central Serous Chorioretinopathy: A Randomized, Open-Label, Controlled Clinical Trial |
| title_fullStr | The Effect of Selective Retina Therapy with Automatic Real-Time Feedback-Controlled Dosimetry for Chronic Central Serous Chorioretinopathy: A Randomized, Open-Label, Controlled Clinical Trial |
| title_full_unstemmed | The Effect of Selective Retina Therapy with Automatic Real-Time Feedback-Controlled Dosimetry for Chronic Central Serous Chorioretinopathy: A Randomized, Open-Label, Controlled Clinical Trial |
| title_short | The Effect of Selective Retina Therapy with Automatic Real-Time Feedback-Controlled Dosimetry for Chronic Central Serous Chorioretinopathy: A Randomized, Open-Label, Controlled Clinical Trial |
| title_sort | effect of selective retina therapy with automatic real time feedback controlled dosimetry for chronic central serous chorioretinopathy a randomized open label controlled clinical trial |
| topic | central serous chorioretinopathy real-time feedback-controlled dosimetry retinal sensitivity selective retina therapy |
| url | https://www.mdpi.com/2077-0383/10/19/4295 |
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