Improved Reversion of Calcifications in Porcine Aortic Heart Valves Using Elastin-Targeted Nanoparticles

Improved Reversion of Calcifications in Porcine Aortic Heart Valves Using Elastin-Targeted Nanoparticles

Calcified aortic valve disease in its final stage leads to aortic valve stenosis, limiting cardiac function. To date, surgical intervention is the only option for treating calcific aortic valve stenosis. This study combined controlled drug delivery by nanoparticles (NPs) and active targeting by anti...

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Bibliographic Details
Main Authors: Anja Feldmann, Yvonne Nitschke, Franziska Linß, Dennis Mulac, Sina Stücker, Jessica Bertrand, Insa Buers, Klaus Langer, Frank Rutsch
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
nanoparticles
aortic valve
calcification
targeted chelation therapy
anti-elastin antibody
Online Access:https://www.mdpi.com/1422-0067/24/22/16471

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