A Study on the Role of Heart Type Fatty Acid Binding Protein in the Diagnosis of Acute Myocardial Infarction
Introduction: Heart type Fatty Acid Binding Protein (H-FABP) has been proposed as an early cardiac biomarker for the diagnosis of acute myocardial Infarction (AMI) using animal models and clinical samples. Aim: The study aimed to evaluate the role of H-FABP in early detection of AMI by comparin...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/7057/15713_CE(RA1)_F(T)_PF1(Ek_Om)_PFA(AK)_PF2(PAG).pdf |
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| author | Shama Prakash Kabekkodu Sudhindra Rao Mananje Rama Prakasha Saya |
| author_facet | Shama Prakash Kabekkodu Sudhindra Rao Mananje Rama Prakasha Saya |
| author_sort | Shama Prakash Kabekkodu |
| collection | DOAJ |
| description | Introduction: Heart type Fatty Acid Binding Protein (H-FABP) has
been proposed as an early cardiac biomarker for the diagnosis of
acute myocardial Infarction (AMI) using animal models and clinical
samples.
Aim: The study aimed to evaluate the role of H-FABP in early
detection of AMI by comparing its sensitivity, specificity and
predictive value with Creatinine Kinase-MB (CK-MB) and Cardiac
Troponin I (cTnI).
Materials and Methods: This is a cross-sectional descriptive
study of 50 patients admitted with the diagnosis of AMI at a tertiary
care hospital in South India. The study group was categorised in
to those coming to the hospital within four hours of symptom
onset and those coming in between 4 to 12 hours. H-FABP was
compared with those of troponin T and myoglobin tests.
Results: Among patients presenting within four hours of symptom
onset, the sensitivity of H-FABP was 60% and was significantly
higher than that of cardiac Troponin I (cTnI, 18.8%) and Creatinine
Kinase (CK)-MB (12.5%). But specificity was only 23.53% and was
less than that of cTnI (66.67%) and CK-MB (100%). In patients
presenting during 4 to 12 hours of symptom onset, the sensitivity
of H-FABP was 86.96% which was comparable to that of cTnI
(90.9%) and CK-MB (77.3%). The specificity was 60% in the 4-12
hours group which was comparable to that of cTnI (50%) and CKMB (50%).
Conclusion: The H-FABP is a sensitive biomarker for the diagnosis
of AMI in the initial hours after symptom onset when the standard
biomarkers may not be elevated, but it is less specific. During 4-12
hours of symptom onset it is as sensitive and specific as standard
cardiac biomarkers troponin and CK-MB. Due to these factors
H-FABP can be considered as a promising cardiac biomarker
which can be used along with troponins and CK-MB at present. |
| first_indexed | 2024-12-12T11:37:28Z |
| format | Article |
| id | doaj.art-03d814d11b7f4a1c96d9ce5c8ecbc7e5 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-12T11:37:28Z |
| publishDate | 2016-01-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-03d814d11b7f4a1c96d9ce5c8ecbc7e52022-12-22T00:25:37ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-01-01101OC07OC1010.7860/JCDR/2016/15713.7057A Study on the Role of Heart Type Fatty Acid Binding Protein in the Diagnosis of Acute Myocardial InfarctionShama Prakash Kabekkodu0Sudhindra Rao Mananje1Rama Prakasha Saya2Associate Professor, Department of General Medicine, KS Hegde Medical Academy, Deralakatte, Mangaluru, India.Associate Professor, Department of General Medicine, KS Hegde Medical Academy, Deralakatte, Mangaluru, India.Assistant Professor, Department of EM and Trauma, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. Introduction: Heart type Fatty Acid Binding Protein (H-FABP) has been proposed as an early cardiac biomarker for the diagnosis of acute myocardial Infarction (AMI) using animal models and clinical samples. Aim: The study aimed to evaluate the role of H-FABP in early detection of AMI by comparing its sensitivity, specificity and predictive value with Creatinine Kinase-MB (CK-MB) and Cardiac Troponin I (cTnI). Materials and Methods: This is a cross-sectional descriptive study of 50 patients admitted with the diagnosis of AMI at a tertiary care hospital in South India. The study group was categorised in to those coming to the hospital within four hours of symptom onset and those coming in between 4 to 12 hours. H-FABP was compared with those of troponin T and myoglobin tests. Results: Among patients presenting within four hours of symptom onset, the sensitivity of H-FABP was 60% and was significantly higher than that of cardiac Troponin I (cTnI, 18.8%) and Creatinine Kinase (CK)-MB (12.5%). But specificity was only 23.53% and was less than that of cTnI (66.67%) and CK-MB (100%). In patients presenting during 4 to 12 hours of symptom onset, the sensitivity of H-FABP was 86.96% which was comparable to that of cTnI (90.9%) and CK-MB (77.3%). The specificity was 60% in the 4-12 hours group which was comparable to that of cTnI (50%) and CKMB (50%). Conclusion: The H-FABP is a sensitive biomarker for the diagnosis of AMI in the initial hours after symptom onset when the standard biomarkers may not be elevated, but it is less specific. During 4-12 hours of symptom onset it is as sensitive and specific as standard cardiac biomarkers troponin and CK-MB. Due to these factors H-FABP can be considered as a promising cardiac biomarker which can be used along with troponins and CK-MB at present.https://jcdr.net/articles/PDF/7057/15713_CE(RA1)_F(T)_PF1(Ek_Om)_PFA(AK)_PF2(PAG).pdfcardiac biomarkerscardiac troponin i (ctni)creatinine kinasesensitivityspecificity |
| spellingShingle | Shama Prakash Kabekkodu Sudhindra Rao Mananje Rama Prakasha Saya A Study on the Role of Heart Type Fatty Acid Binding Protein in the Diagnosis of Acute Myocardial Infarction Journal of Clinical and Diagnostic Research cardiac biomarkers cardiac troponin i (ctni) creatinine kinase sensitivity specificity |
| title | A Study on the Role of Heart Type Fatty Acid Binding Protein in the Diagnosis of Acute Myocardial Infarction |
| title_full | A Study on the Role of Heart Type Fatty Acid Binding Protein in the Diagnosis of Acute Myocardial Infarction |
| title_fullStr | A Study on the Role of Heart Type Fatty Acid Binding Protein in the Diagnosis of Acute Myocardial Infarction |
| title_full_unstemmed | A Study on the Role of Heart Type Fatty Acid Binding Protein in the Diagnosis of Acute Myocardial Infarction |
| title_short | A Study on the Role of Heart Type Fatty Acid Binding Protein in the Diagnosis of Acute Myocardial Infarction |
| title_sort | study on the role of heart type fatty acid binding protein in the diagnosis of acute myocardial infarction |
| topic | cardiac biomarkers cardiac troponin i (ctni) creatinine kinase sensitivity specificity |
| url | https://jcdr.net/articles/PDF/7057/15713_CE(RA1)_F(T)_PF1(Ek_Om)_PFA(AK)_PF2(PAG).pdf |
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