Solubility measurement of poorly soluble drugs in fasted state simulated intestinal fluid
Adequate drug solubility in the gastrointestinal tract is essential for systemic therapy of orally administered medications. To carry out research on the solubility of poorly soluble drugs in vitro, simulated intestinal fluid (SIF) is used in place of human intestinal fluid (HIF). However, typical S...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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University of Huddersfield Press
2022-11-01
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| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/id/1075/ |
| Summary: | Adequate drug solubility in the gastrointestinal tract is essential for systemic therapy of orally administered medications. To carry out research on the solubility of poorly soluble drugs in vitro, simulated intestinal fluid (SIF) is used in place of human intestinal fluid (HIF). However, typical SIF reflects average compositions of HIF rather than the full range of compositions previously reported. This study examines a new suite of SIF media (based on variability observed in HIF) to explore the range of solubility of four poorly soluble drugs(Naproxen, Indomethacin, Phenytoin and Tadalafil) in the fasted state. |
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| ISSN: | 2058-8356 |