Serotype distribution of Streptococcus pneumoniae and pneumococcal vaccine coverage in adults in Turkey between 2015 and 2018
AbstractObjective To evaluate the serotype distribution and antibiotic resistance in pneumococcal infections in adults and to provide a perspective regarding serotype coverage of both current and future pneumococcal vaccines.Patients and methods This passive surveillance study was conducted with the...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2022.2160877 |
| _version_ | 1797353710699937792 |
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| author | Gulsen Hascelik Guner Soyletir Zeynep Gulay Banu Sancak Akgun Yaman Nezahat Gurler Sabire Sohret Aydemir Gulcin Bayramoglu Faruk Aydin Yesim Cekin Asuman Birinci Cuneyt Ozakin Nezahat Akpolat Betil Ozhak Baysan Meral Gultekin Yasemin Zer Laser Sanal Cigdem Arabaci Yasemin Ay Altintop Candan Ozturk Mehmet Ceyhan |
| author_facet | Gulsen Hascelik Guner Soyletir Zeynep Gulay Banu Sancak Akgun Yaman Nezahat Gurler Sabire Sohret Aydemir Gulcin Bayramoglu Faruk Aydin Yesim Cekin Asuman Birinci Cuneyt Ozakin Nezahat Akpolat Betil Ozhak Baysan Meral Gultekin Yasemin Zer Laser Sanal Cigdem Arabaci Yasemin Ay Altintop Candan Ozturk Mehmet Ceyhan |
| author_sort | Gulsen Hascelik |
| collection | DOAJ |
| description | AbstractObjective To evaluate the serotype distribution and antibiotic resistance in pneumococcal infections in adults and to provide a perspective regarding serotype coverage of both current and future pneumococcal vaccines.Patients and methods This passive surveillance study was conducted with the Streptococcus pneumoniae strains isolated from the specimens of patients with pneumonia (materials isolated from bronchoalveolar lavage), bacteraemia, meningitis, pleuritis and peritonitis between 2015 and 2018. Serogrouping and serotyping were performed by latex particle agglutination and by conventional Quellung reaction using commercial type-specific antisera, respectively. The strains were analysed for penicillin, cefotaxime, erythromycin and moxifloxacin susceptibilities by E-test.Results In the whole study group (410 samples from adults aged ≥18 years), the most frequent serotypes were 3 (14.1%), 19 F (12%) and 1 (9.3%). The vaccine coverage for PCV13, PCV15, PCV20 and PPV23 was 63.9%, 66.6%, 74.1% and 75.9%, respectively, in all isolates. Penicillin non-susceptibility in invasive pneumococcal disease (IPD) was 70.8% and 57.1% in the patients aged <65 and ≥65 years, respectively. About 21.1% and 4.3% of the patients with and without IPD had cefotaxime resistance. Non-susceptibility to erythromycin and moxifloxacin was 38.2% and 1.2%, respectively.Conclusions The results revealed that novel PCV vaccines may provide improved coverage as compared with the currently available vaccine, PCV13. The significant antibiotic resistance rates imply the need to extend the serotype coverage of the vaccines. Continuing the surveillance in pneumococcal diseases is critical to explore the serotype distribution and incidence changes of IPD cases in the population and to inform policy makers to make necessary improvements in the national immunization programmes.Key messagesThis multicentre study demonstrated the most recent serotype distribution and antibiotic resistance in adult population in Turkey.Shifting from PCV13 to novel conjugated vaccines will significantly increase the coverage.Continuing the surveillance in pneumococcal diseases is critical to explore the serotype distribution changes and the incidence of cases with invasive pneumococcal disease in the population. |
| first_indexed | 2024-03-08T13:34:58Z |
| format | Article |
| id | doaj.art-03db9891a7444c149960e05e8dbb14fb |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:34:58Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-03db9891a7444c149960e05e8dbb14fb2024-01-16T19:13:22ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155126627510.1080/07853890.2022.2160877Serotype distribution of Streptococcus pneumoniae and pneumococcal vaccine coverage in adults in Turkey between 2015 and 2018Gulsen Hascelik0Guner Soyletir1Zeynep Gulay2Banu Sancak3Akgun Yaman4Nezahat Gurler5Sabire Sohret Aydemir6Gulcin Bayramoglu7Faruk Aydin8Yesim Cekin9Asuman Birinci10Cuneyt Ozakin11Nezahat Akpolat12Betil Ozhak Baysan13Meral Gultekin14Yasemin Zer15Laser Sanal16Cigdem Arabaci17Yasemin Ay Altintop18Candan Ozturk19Mehmet Ceyhan20Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, TurkeyDepartment of Medical Microbiology, Marmara University, Pendik Training and Research Hospital, Istanbul, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Dokuz Eylul University, Izmir, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Cukurova University, Adana, TurkeyDepartment of Microbiology and Clinical Microbiology, Faculty of Medicine, Istanbul University, Istanbul, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Ege University, Izmir, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, TurkeyDepartment of Medical Microbiology, Antalya Training and Research Hospital, Antalya, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Samsun Ondokuz Mayıs University, Samsun, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Bursa Uludag University, Bursa, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Dicle University, Diyarbakir, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Akdeniz University, Antalya, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Akdeniz University, Antalya, TurkeyDepartment of Microbiology, Faculty of Medicine, Gaziantep University, Gaziantep, TurkeyDepartment of Clinical Microbiology, Ankara Yuksek Ihtisas Training and Research Hospital, Ankara, TurkeyDepartment of Microbiology and Clinical Microbiology, Istanbul Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, TurkeyDepartment of Medical Microbiology, Kayseri City Training and Research Hospital, Kayseri, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Mersin University, Mersin, TurkeyDepartment of Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, TurkeyAbstractObjective To evaluate the serotype distribution and antibiotic resistance in pneumococcal infections in adults and to provide a perspective regarding serotype coverage of both current and future pneumococcal vaccines.Patients and methods This passive surveillance study was conducted with the Streptococcus pneumoniae strains isolated from the specimens of patients with pneumonia (materials isolated from bronchoalveolar lavage), bacteraemia, meningitis, pleuritis and peritonitis between 2015 and 2018. Serogrouping and serotyping were performed by latex particle agglutination and by conventional Quellung reaction using commercial type-specific antisera, respectively. The strains were analysed for penicillin, cefotaxime, erythromycin and moxifloxacin susceptibilities by E-test.Results In the whole study group (410 samples from adults aged ≥18 years), the most frequent serotypes were 3 (14.1%), 19 F (12%) and 1 (9.3%). The vaccine coverage for PCV13, PCV15, PCV20 and PPV23 was 63.9%, 66.6%, 74.1% and 75.9%, respectively, in all isolates. Penicillin non-susceptibility in invasive pneumococcal disease (IPD) was 70.8% and 57.1% in the patients aged <65 and ≥65 years, respectively. About 21.1% and 4.3% of the patients with and without IPD had cefotaxime resistance. Non-susceptibility to erythromycin and moxifloxacin was 38.2% and 1.2%, respectively.Conclusions The results revealed that novel PCV vaccines may provide improved coverage as compared with the currently available vaccine, PCV13. The significant antibiotic resistance rates imply the need to extend the serotype coverage of the vaccines. Continuing the surveillance in pneumococcal diseases is critical to explore the serotype distribution and incidence changes of IPD cases in the population and to inform policy makers to make necessary improvements in the national immunization programmes.Key messagesThis multicentre study demonstrated the most recent serotype distribution and antibiotic resistance in adult population in Turkey.Shifting from PCV13 to novel conjugated vaccines will significantly increase the coverage.Continuing the surveillance in pneumococcal diseases is critical to explore the serotype distribution changes and the incidence of cases with invasive pneumococcal disease in the population.https://www.tandfonline.com/doi/10.1080/07853890.2022.2160877Streptococcus pneumoniaeserotypesurveillancevaccine coverageantibiotic susceptibility |
| spellingShingle | Gulsen Hascelik Guner Soyletir Zeynep Gulay Banu Sancak Akgun Yaman Nezahat Gurler Sabire Sohret Aydemir Gulcin Bayramoglu Faruk Aydin Yesim Cekin Asuman Birinci Cuneyt Ozakin Nezahat Akpolat Betil Ozhak Baysan Meral Gultekin Yasemin Zer Laser Sanal Cigdem Arabaci Yasemin Ay Altintop Candan Ozturk Mehmet Ceyhan Serotype distribution of Streptococcus pneumoniae and pneumococcal vaccine coverage in adults in Turkey between 2015 and 2018 Annals of Medicine Streptococcus pneumoniae serotype surveillance vaccine coverage antibiotic susceptibility |
| title | Serotype distribution of Streptococcus pneumoniae and pneumococcal vaccine coverage in adults in Turkey between 2015 and 2018 |
| title_full | Serotype distribution of Streptococcus pneumoniae and pneumococcal vaccine coverage in adults in Turkey between 2015 and 2018 |
| title_fullStr | Serotype distribution of Streptococcus pneumoniae and pneumococcal vaccine coverage in adults in Turkey between 2015 and 2018 |
| title_full_unstemmed | Serotype distribution of Streptococcus pneumoniae and pneumococcal vaccine coverage in adults in Turkey between 2015 and 2018 |
| title_short | Serotype distribution of Streptococcus pneumoniae and pneumococcal vaccine coverage in adults in Turkey between 2015 and 2018 |
| title_sort | serotype distribution of streptococcus pneumoniae and pneumococcal vaccine coverage in adults in turkey between 2015 and 2018 |
| topic | Streptococcus pneumoniae serotype surveillance vaccine coverage antibiotic susceptibility |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2022.2160877 |
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