A mRNA-Responsive G-Quadruplex-Based Drug Release System

A mRNA-Responsive G-Quadruplex-Based Drug Release System

G-quadruplex-based drug delivery carriers (GDDCs) were designed to capture and release a telomerase inhibitor in response to a target mRNA. Hybridization between a loop on the GDDC structure and the mRNA should cause the G-quadruplex structure of the GDDC to unfold and release the bound inhibitor, a...

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Bibliographic Details
Main Authors: Hidenobu Yaku, Takashi Murashima, Daisuke Miyoshi, Naoki Sugimoto
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Sensors
Subjects:
drug delivery carrier
G-quadruplex
anionic phthalocyanine
cancer
mRNA
telomerase
Online Access:http://www.mdpi.com/1424-8220/15/4/9388

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