Microfluidic Fabrication of Monodisperse Microcapsules for Thermo-Triggered Release of Liposoluble Drugs
Here, we report a novel thermo-triggered-releasing microcapsule for liposoluble drug delivery. Monodisperse microcapsules with a poly(N-isopropylacrylamide-<i>co</i>-methacrylic acid) hydrogel shell and an oil core were successfully fabricated by a double coaxial microfluidic device. Flu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/10/2200 |
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| author | Yuanyuan Wang Yongyue Li Jinghua Gong Jinghong Ma |
| author_facet | Yuanyuan Wang Yongyue Li Jinghua Gong Jinghong Ma |
| author_sort | Yuanyuan Wang |
| collection | DOAJ |
| description | Here, we report a novel thermo-triggered-releasing microcapsule for liposoluble drug delivery. Monodisperse microcapsules with a poly(N-isopropylacrylamide-<i>co</i>-methacrylic acid) hydrogel shell and an oil core were successfully fabricated by a double coaxial microfluidic device. Fluorescent dye Lumogen Red F300 as a model liposoluble drug was dissolved in the oil core with controllable loading capacity. The volume phase transition temperature (VPTT) of the microcapsule was adjusted by copolymerizing with the hydrophilic methacrylic acid. The in vitro release study demonstrates that the shells shrink, leading to the thermo-triggered release of the model drug from the microcapsules at the environmental temperature above the VPTT, while the swollen hydrogel shells can protect the encapsulated drug from leakage and contamination below the VPTT. The proposed microcapsule is a promising liposoluble drug delivery system with controllable loading and smart thermo-triggered release. |
| first_indexed | 2024-03-10T16:02:21Z |
| format | Article |
| id | doaj.art-03dde2fdbdf7403bbb0f9aeeb1f7f217 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T16:02:21Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-03dde2fdbdf7403bbb0f9aeeb1f7f2172023-11-20T15:06:11ZengMDPI AGPolymers2073-43602020-09-011210220010.3390/polym12102200Microfluidic Fabrication of Monodisperse Microcapsules for Thermo-Triggered Release of Liposoluble DrugsYuanyuan Wang0Yongyue Li1Jinghua Gong2Jinghong Ma3State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, ChinaState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, ChinaState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, ChinaState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, ChinaHere, we report a novel thermo-triggered-releasing microcapsule for liposoluble drug delivery. Monodisperse microcapsules with a poly(N-isopropylacrylamide-<i>co</i>-methacrylic acid) hydrogel shell and an oil core were successfully fabricated by a double coaxial microfluidic device. Fluorescent dye Lumogen Red F300 as a model liposoluble drug was dissolved in the oil core with controllable loading capacity. The volume phase transition temperature (VPTT) of the microcapsule was adjusted by copolymerizing with the hydrophilic methacrylic acid. The in vitro release study demonstrates that the shells shrink, leading to the thermo-triggered release of the model drug from the microcapsules at the environmental temperature above the VPTT, while the swollen hydrogel shells can protect the encapsulated drug from leakage and contamination below the VPTT. The proposed microcapsule is a promising liposoluble drug delivery system with controllable loading and smart thermo-triggered release.https://www.mdpi.com/2073-4360/12/10/2200microcapsulepoly(N-isopropylacrylamide-<i>co</i>-methacrylic acid)double coaxial microfluidic devicethermo-triggered releaseliposoluble drug |
| spellingShingle | Yuanyuan Wang Yongyue Li Jinghua Gong Jinghong Ma Microfluidic Fabrication of Monodisperse Microcapsules for Thermo-Triggered Release of Liposoluble Drugs Polymers microcapsule poly(N-isopropylacrylamide-<i>co</i>-methacrylic acid) double coaxial microfluidic device thermo-triggered release liposoluble drug |
| title | Microfluidic Fabrication of Monodisperse Microcapsules for Thermo-Triggered Release of Liposoluble Drugs |
| title_full | Microfluidic Fabrication of Monodisperse Microcapsules for Thermo-Triggered Release of Liposoluble Drugs |
| title_fullStr | Microfluidic Fabrication of Monodisperse Microcapsules for Thermo-Triggered Release of Liposoluble Drugs |
| title_full_unstemmed | Microfluidic Fabrication of Monodisperse Microcapsules for Thermo-Triggered Release of Liposoluble Drugs |
| title_short | Microfluidic Fabrication of Monodisperse Microcapsules for Thermo-Triggered Release of Liposoluble Drugs |
| title_sort | microfluidic fabrication of monodisperse microcapsules for thermo triggered release of liposoluble drugs |
| topic | microcapsule poly(N-isopropylacrylamide-<i>co</i>-methacrylic acid) double coaxial microfluidic device thermo-triggered release liposoluble drug |
| url | https://www.mdpi.com/2073-4360/12/10/2200 |
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