Epigenetic Regulation of the Non-Coding Genome: Opportunities for Immuno-Oncology
The contribution of the non-coding genome to disease and its therapeutic potential have been largely unexplored. Recently, several epigenetic drugs developed for cancer treatment have been described to mediate therapeutic effects through the reactivation of the expression of transposable elements in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Epigenomes |
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| Online Access: | https://www.mdpi.com/2075-4655/4/3/22 |
| _version_ | 1797553969802772480 |
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| author | Maria J. Barrero |
| author_facet | Maria J. Barrero |
| author_sort | Maria J. Barrero |
| collection | DOAJ |
| description | The contribution of the non-coding genome to disease and its therapeutic potential have been largely unexplored. Recently, several epigenetic drugs developed for cancer treatment have been described to mediate therapeutic effects through the reactivation of the expression of transposable elements in cancer cells. This event activates innate immunity-related pathways and promotes the generation of neoantigens in tumor cells, improving the efficacy of immunotherapeutic treatments. This review focuses on the regulation of transposable elements by epigenetic inhibitors and its implications for immuno-oncology. |
| first_indexed | 2024-03-10T16:25:05Z |
| format | Article |
| id | doaj.art-03ded787dbe14a00af8a1296b6e7237e |
| institution | Directory Open Access Journal |
| issn | 2075-4655 |
| language | English |
| last_indexed | 2024-03-10T16:25:05Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Epigenomes |
| spelling | doaj.art-03ded787dbe14a00af8a1296b6e7237e2023-11-20T13:18:39ZengMDPI AGEpigenomes2075-46552020-09-01432210.3390/epigenomes4030022Epigenetic Regulation of the Non-Coding Genome: Opportunities for Immuno-OncologyMaria J. Barrero0Independent Researcher, 28049 Madrid, SpainThe contribution of the non-coding genome to disease and its therapeutic potential have been largely unexplored. Recently, several epigenetic drugs developed for cancer treatment have been described to mediate therapeutic effects through the reactivation of the expression of transposable elements in cancer cells. This event activates innate immunity-related pathways and promotes the generation of neoantigens in tumor cells, improving the efficacy of immunotherapeutic treatments. This review focuses on the regulation of transposable elements by epigenetic inhibitors and its implications for immuno-oncology.https://www.mdpi.com/2075-4655/4/3/22epigeneticsimmuno-oncologyrepetitive elementsdsRNAcancerimmunotherapy |
| spellingShingle | Maria J. Barrero Epigenetic Regulation of the Non-Coding Genome: Opportunities for Immuno-Oncology Epigenomes epigenetics immuno-oncology repetitive elements dsRNA cancer immunotherapy |
| title | Epigenetic Regulation of the Non-Coding Genome: Opportunities for Immuno-Oncology |
| title_full | Epigenetic Regulation of the Non-Coding Genome: Opportunities for Immuno-Oncology |
| title_fullStr | Epigenetic Regulation of the Non-Coding Genome: Opportunities for Immuno-Oncology |
| title_full_unstemmed | Epigenetic Regulation of the Non-Coding Genome: Opportunities for Immuno-Oncology |
| title_short | Epigenetic Regulation of the Non-Coding Genome: Opportunities for Immuno-Oncology |
| title_sort | epigenetic regulation of the non coding genome opportunities for immuno oncology |
| topic | epigenetics immuno-oncology repetitive elements dsRNA cancer immunotherapy |
| url | https://www.mdpi.com/2075-4655/4/3/22 |
| work_keys_str_mv | AT mariajbarrero epigeneticregulationofthenoncodinggenomeopportunitiesforimmunooncology |