Epitope-tagged and phosphomimetic mouse models for investigating natriuretic peptide-stimulated receptor guanylyl cyclases

Epitope-tagged and phosphomimetic mouse models for investigating natriuretic peptide-stimulated receptor guanylyl cyclases

The natriuretic peptide receptors NPR1 and NPR2, also known as guanylyl cyclase A and guanylyl cyclase B, have critical functions in many signaling pathways, but much remains unknown about their localization and function in vivo. To facilitate studies of these proteins, we developed genetically modi...

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Bibliographic Details
Main Authors: Jeremy R. Egbert, Tracy F. Uliasz, Katie M. Lowther, Deborah Kaback, Brandon M. Wagner, Chastity L. Healy, Timothy D. O’Connell, Lincoln R. Potter, Laurinda A. Jaffe, Siu-Pok Yee
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
natriuretic peptide receptor
guanylyl cyclase
phosphorylation
genetically modified mice
cyclic GMP
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1007026/full

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