Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure Treatment
This study was aimed at investigating the functional connectivity (FC) changes between the insular subregions and whole brain in patients with obstructive sleep apnea (OSA) after 6 months of continuous positive airway pressure (CPAP) treatment and at exploring the relationship between resting-state...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2023/5598047 |
| _version_ | 1797869946275889152 |
|---|---|
| author | Ting Long Haijun Li Yongqiang Shu Kunyao Li Wei Xie Yaping Zeng Ling Huang Li Zeng Xiang Liu Dechang Peng |
| author_facet | Ting Long Haijun Li Yongqiang Shu Kunyao Li Wei Xie Yaping Zeng Ling Huang Li Zeng Xiang Liu Dechang Peng |
| author_sort | Ting Long |
| collection | DOAJ |
| description | This study was aimed at investigating the functional connectivity (FC) changes between the insular subregions and whole brain in patients with obstructive sleep apnea (OSA) after 6 months of continuous positive airway pressure (CPAP) treatment and at exploring the relationship between resting-state FC changes and cognitive impairment in OSA patients. Data from 15 patients with OSA before and after 6 months of CPAP treatment were included in this study. The FC between the insular subregions and whole brain was compared between baseline and after 6 months of CPAP treatment in OSA. After 6 months of treatment, OSA patients had increased FC from the right ventral anterior insula to the bilateral superior frontal gyrus and bilateral middle frontal gyrus and increased FC from the left posterior insula to the left middle temporal gyrus and left inferior temporal gyrus. Hyperconnectivity was found from the right posterior insula to the right middle temporal gyrus, bilateral precuneus, and bilateral posterior cingulate cortex, which mainly involved the default mode network. There are changes in functional connectivity patterns between the insular subregions and whole brain in OSA patients after 6 months of CPAP treatment. These changes provide a better understanding of the neuroimaging mechanisms underlying the improvement in cognitive function and emotional impairment in OSA patients and can be used as potential biomarkers for clinical CPAP treatment. |
| first_indexed | 2024-04-10T00:20:36Z |
| format | Article |
| id | doaj.art-03df6bddcafd4cc1a1632485288b4ba0 |
| institution | Directory Open Access Journal |
| issn | 1687-5443 |
| language | English |
| last_indexed | 2024-04-10T00:20:36Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj.art-03df6bddcafd4cc1a1632485288b4ba02023-03-16T00:01:38ZengHindawi LimitedNeural Plasticity1687-54432023-01-01202310.1155/2023/5598047Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure TreatmentTing Long0Haijun Li1Yongqiang Shu2Kunyao Li3Wei Xie4Yaping Zeng5Ling Huang6Li Zeng7Xiang Liu8Dechang Peng9Medical Imaging CenterMedical Imaging CenterMedical Imaging CenterMedical Imaging CenterMedical Imaging CenterMedical Imaging CenterMedical Imaging CenterMedical Imaging CenterMedical Imaging CenterMedical Imaging CenterThis study was aimed at investigating the functional connectivity (FC) changes between the insular subregions and whole brain in patients with obstructive sleep apnea (OSA) after 6 months of continuous positive airway pressure (CPAP) treatment and at exploring the relationship between resting-state FC changes and cognitive impairment in OSA patients. Data from 15 patients with OSA before and after 6 months of CPAP treatment were included in this study. The FC between the insular subregions and whole brain was compared between baseline and after 6 months of CPAP treatment in OSA. After 6 months of treatment, OSA patients had increased FC from the right ventral anterior insula to the bilateral superior frontal gyrus and bilateral middle frontal gyrus and increased FC from the left posterior insula to the left middle temporal gyrus and left inferior temporal gyrus. Hyperconnectivity was found from the right posterior insula to the right middle temporal gyrus, bilateral precuneus, and bilateral posterior cingulate cortex, which mainly involved the default mode network. There are changes in functional connectivity patterns between the insular subregions and whole brain in OSA patients after 6 months of CPAP treatment. These changes provide a better understanding of the neuroimaging mechanisms underlying the improvement in cognitive function and emotional impairment in OSA patients and can be used as potential biomarkers for clinical CPAP treatment.http://dx.doi.org/10.1155/2023/5598047 |
| spellingShingle | Ting Long Haijun Li Yongqiang Shu Kunyao Li Wei Xie Yaping Zeng Ling Huang Li Zeng Xiang Liu Dechang Peng Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure Treatment Neural Plasticity |
| title | Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure Treatment |
| title_full | Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure Treatment |
| title_fullStr | Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure Treatment |
| title_full_unstemmed | Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure Treatment |
| title_short | Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure Treatment |
| title_sort | functional connectivity changes in the insular subregions of patients with obstructive sleep apnea after 6 months of continuous positive airway pressure treatment |
| url | http://dx.doi.org/10.1155/2023/5598047 |
| work_keys_str_mv | AT tinglong functionalconnectivitychangesintheinsularsubregionsofpatientswithobstructivesleepapneaafter6monthsofcontinuouspositiveairwaypressuretreatment AT haijunli functionalconnectivitychangesintheinsularsubregionsofpatientswithobstructivesleepapneaafter6monthsofcontinuouspositiveairwaypressuretreatment AT yongqiangshu functionalconnectivitychangesintheinsularsubregionsofpatientswithobstructivesleepapneaafter6monthsofcontinuouspositiveairwaypressuretreatment AT kunyaoli functionalconnectivitychangesintheinsularsubregionsofpatientswithobstructivesleepapneaafter6monthsofcontinuouspositiveairwaypressuretreatment AT weixie functionalconnectivitychangesintheinsularsubregionsofpatientswithobstructivesleepapneaafter6monthsofcontinuouspositiveairwaypressuretreatment AT yapingzeng functionalconnectivitychangesintheinsularsubregionsofpatientswithobstructivesleepapneaafter6monthsofcontinuouspositiveairwaypressuretreatment AT linghuang functionalconnectivitychangesintheinsularsubregionsofpatientswithobstructivesleepapneaafter6monthsofcontinuouspositiveairwaypressuretreatment AT lizeng functionalconnectivitychangesintheinsularsubregionsofpatientswithobstructivesleepapneaafter6monthsofcontinuouspositiveairwaypressuretreatment AT xiangliu functionalconnectivitychangesintheinsularsubregionsofpatientswithobstructivesleepapneaafter6monthsofcontinuouspositiveairwaypressuretreatment AT dechangpeng functionalconnectivitychangesintheinsularsubregionsofpatientswithobstructivesleepapneaafter6monthsofcontinuouspositiveairwaypressuretreatment |